03-24-2005, 07:19 PM #1Anabolic Member
- Join Date
- Mar 2004
Getting the most out of NO supps. How omega 3's suppress its action. ????
Interesting article. Seems our preciouse little omega 3s are limiting our gains. Well...maybe. Supposedly omega 3's can suppress NO, but omega 6s and 9s can't.
So should we dump the fish oils and switch to olive oil? hmmm. interesting.
this is under number 2 on the site:
Although nitric oxide (NO) is an important biological mediator, its excessive production in inflammation is thought to be a causative factor for cellular injury and, over the long term, cancer. In the present study, the effects of several fatty acids on NO production in murine macrophage cell line RAW264 cells stimulated with lipopolysaccharide were examined. Suppression of NO production was observed with the omega 3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid, eicosapentaenoic acid and alpha-linolenic acid, in a dose-dependent fashion. In contrast, no inhibition was observed with omega 6 PUFA (linoleic acid), omega 9 PUFA (oleic acid) or a saturated fatty acid (stearic acid). Western and northern blot analyses suggested that suppression of the induction of inducible NO synthase gene expression is responsible for the inhibition of NO production by omega 3 PUFAs. The inhibitory effect of omega 3 PUFA on NO production in activated macrophages could contribute to their cancer chemopreventive influence.
03-25-2005, 02:03 AM #2
Take 6g of fish oil a day. Dont worry about NO. If your worried, supplement with an NO Booster.
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