12-04-2005, 06:28 AM #1
to all worried about finasteride for hair loss
I heard many myths on finasteride one of this is that reduce testosterone and increase estrogen. I never experienced this and i feel horny all the time even if i have used finasteride for 10 years without stopping. Here there is a recent study (2004) that actually proves that fina increase serum testosterone. This makes sense because neutralising dht free more testosterone
Effects of finasteride on serum testosterone and body mass index in men with benign prostatic hyperplasia.
Roehrborn CG, Lee M, Meehan A, Waldstreicher J; PLESS Study Group.
University of Texas Southwestern Medical Center, Dallas, Texas 75390-9110, USA
OBJECTIVES: To examine the effect of finasteride on serum testosterone in men with benign prostatic hyperplasia (BPH). METHODS: The Proscar Long-Term Efficacy and Safety Study (PLESS) was a 4-year trial comparing the safety and efficacy of finasteride 5 mg with placebo in 3040 men with moderate to severe symptomatic BPH and enlarged prostates. PLESS included the prospective measurement of annual serum testosterone in a randomly selected subset of patients comprising approximately 10% of the randomized population (n = 301). RESULTS: Finasteride treatment led to a modest, but significant (P <0.001), increase relative to placebo in serum testosterone, with this increase greatest in patients who had low baseline testosterone levels . The larger testosterone increases seen in finasteride-treated patients in the lower baseline testosterone tertiles were associated with significant mean reductions relative to placebo at year 4 in body mass index (BMI), ranging from 0.6 to 0.8 kg/m2. No statistically significant between-group difference was found in BMI in the upper testosterone tertile. The sexual adverse experience profiles for finasteride and placebo were similar across the baseline testosterone cohorts examined. CONCLUSIONS: Finasteride treatment led to a generally modest increase relative to placebo in serum testosterone, with the greatest increases occurring in men with low baseline testosterone levels. The physiologic significance of these changes in men with low baseline testosterone levels is unclear, but the associated reduction in BMI is intriguing and may be related, because BMI is known to be negatively correlated with serum testosterone levels in men.
Randomized Controlled Trial
12-04-2005, 09:34 AM #2
good stuff It doesnt lower T levels just DHT levels which is a main factor in hair thinning.
DHT is very strong and having a lower amount of it can alter the way your body deals with the presence of estrogen. Although while not raising estrogen it can in some cause estrogen related sides because there is not enough DHT to bind to receptors leaving estrogen to wreak its havoc.
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