Originally Posted by
DocToxin8
Interesting about aspirins potentiating of thermogenic effect.
I'll look more into that.
As far as pH goes, you are taking about the pH of URINE, not the blood.
If pH in the blood changed by just one degree pH either way you would have serious issues.
But the urine is another matter.
Consuming lots of bicarbonate (baking soda) will raise the pH of the urine,
which in turn would inhibit the excretion of a lot of stims: amphetamine, methamph, ephedrine, and so on.
This is because these alkaloids, f.ex amphetamine is basic in nature.
It's this more soluble in acidic solutions than alkaline,
and since these stims are predominantly excreted unchanged in the urine,
(Not broken down by the liver),
the pH of the urine will affect half life greatly.
Increase urine pH to prolong half life,
Lower urine pH (with f.ex Citric acid, maybe ascorbic acid) and increase excretion.
However, do not rely on this to prolong the duration of effect.
Why? Because ephedrine is cheap and you'd be better of just re dosing than consuming lots of baking soda. Higher half life doesn't necessarily mean that much longer active life either, but may rather just increase tolerance more quickly. Also, consuming baking soda regularly may affect excretion of other compounds you may very well want to get rid of.
Use the regular ECA stack if you will,
up the ephedrine of you need to, but I'd advise against tying to inhibit excretion by upping urinary pH.
In emergency poisoning with amphetamine its common to acidify the urine,
but doing this (or the reverse of this) over weeks on end may lead to issues you don't want. And unlike combining caffeine with ephedrine which is synergistic on fat burning, I don't think there's anything to be gained that you can't accomplish much better by just upping the dose a little.