INPUT on possible article ????

[Merc.]

Hey all,

Was thinking about writing something for the board .. I wanted to know if you guys wanted me to possibly write about about a certain topic you are interested in ? Steroid related ( of course) ... For those of you who dont know me .. I really like to write about AAS .. There are a few of my older articles floating around here ..

So if any of you would like to hit me up with topics maybe we could throw up a very informative article .. Maybe we can have a few different writers ( if any are interested) contribute to the article ( that would really be great , I think )......

Toughts, Feedback???? Anyone into doing something like this ??


Merc.

[LexusIS09]

something about SERMS. there's so little info out right now..

[CHAP]

How about something that discribes results of peoples bloodwork aand what could cause results like -

High LDL
Low HDL
Liver results
ect

This could be helpful to those on TRT getting lots of bloodwork done

Also would be impotant to the newbes insisting on oral cycles without the knowlege of what results that it can have on a lipid profile.

[CBGB]

^^^^x2

[Narkissos]

Merc. 'eh?

[Merc.]

Merc. 'eh?

Yea tis me ..

sup man ????




Merc.

[WARMachine]

Id like some more info about PCT.

I think there is all kinds of groundbreaking things happening lately, i think its time for information to be brought to us.

I would undertake this myself, but im really strapped for time as of late.

[Narkissos]

Yea tis me ..

sup man ????


Merc.

Nothing much.

re: collaboration... That's a solid idea.

I wonder if Magic32 would be interested in something like that.

[*RAGE*]

I would like to see some HGH, studies and cycles I am sure it would not take you long to write about them.

[amcon]

good to see you stayed - i will be interested in reading what ever you do...

i would like you to write on aas and how it effects prone's mind... thanks

[T-MOS]

I would like to see some DOSAGE studies

as I believe more food is sometimes better then more steroids

[*RAGE*]

good to see you stayed - i will be interested in reading what ever you do...

i would like you to write on aas and how it effects prone's mind... thanks

I have lost my mind, my first exwife got it in the divorce along with everything else.."bitch"

[IM708]

More solid info on SARMS would be great.

[sigman roid]

More solid info on SARMS would be great.

agreed x2

[magic32]

Nothing much.

re: collaboration... That's a solid idea.

I wonder if Magic32 would be interested in something like that.

Sup Nark?

Yeah Merc that is something I've been wondering about, but it bears some research. Could you write something about how a bioassay based on electrophysiological assessment of GABAA receptor function and optical measurements of cellular accumulation of a fluorescent steroid analogue suggest that γ-cyclodextrin sequesters steroids rather than directly influencing GABAA receptor function?

Or Nark if you just know it off hand please chime in.

Thanks.

[peachfuzz]

sup nark?

Yeah merc that is something i've been wondering about, but it bears some research. Could you write something about how a bioassay based on electrophysiological assessment of gabaa receptor function and optical measurements of cellular accumulation of a fluorescent steroid analogue suggest that γ-cyclodextrin sequesters steroids rather than directly influencing gabaa receptor function?

Or nark if you just know it off hand please chime in.

Thanks.

the answer is...

A) 1/3

[peachfuzz]

On a serious note i would love to see something on the neurological effects of anabolic steroids or something easier to write would be the effects on the cardiovascular system.

I think these are very real risks associated with steroid use and should be not be overlooked.

Whatever you write im sure it will make for a good read.

[MuscleScience]

I have this theory that stacking two or more compounds with different binding affinities for the AR will compete with each other. Thus causing one compounds effects to effectively be blocked or reduced. This is the how compounds like tamoxifen citrate effectively block estrogens effects on the ER.

[peachfuzz]

^stupid

[WARMachine]

Sup Nark?

Yeah Merc that is something I've been wondering about, but it bears some research. Could you write something about how a bioassay based on electrophysiological assessment of GABAA receptor function and optical measurements of cellular accumulation of a fluorescent steroid analogue suggest that γ-cyclodextrin sequesters steroids rather than directly influencing GABAA receptor function?

Or Nark if you just know it off hand please chime in.

Thanks.

Ill get back to you on that...

[magic32]

the answer is...
A) 1/3

LOL, as any Hitchhiker's Guide knowledgeable person knows the answer is "42".

Ill get back to you on that...

All kidding aside this is a very serious question with some significant ramifications, peripheral to which happens to be the answer to MS’s (I always liked this guy) present & extremely apt question:

I have this theory that stacking two or more compounds with different binding affinities for the AR will compete with each other. Thus causing one compounds effects to effectively be blocked or reduced. This is the how compounds like tamoxifen citrate effectively block estrogens effects on the ER.

There really is a very rational and comprehensible answer to both of our questions which has to do the two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone and 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10(-7) and 10(-5)M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons. These data may explain the ability of certain steroid hormones (and other contraindicative hormone related drugs like SERMs and AIs) to rapidly alter neuronal excitability and may provide a mechanism for the inhibiting actions of numerous naturally occurring bodiliy chemicals as well as, both synthetic anesthetic & "YES" believe it or not, similarly reactive anabolic steroid synthesis.

Merc,

Should you be so inclined, here are some of the central resources...

http://www.pubmedcentral.nih.gov/art...?artid=2042897
http://www.ncbi.nlm.nih.gov/pubmed/15282269
http://www.ncbi.nlm.nih.gov/pubmed/16702996
http://www.ncbi.nlm.nih.gov/pubmed/2598927
http://www.ncbi.nlm.nih.gov/pubmed/2888123
http://www.ncbi.nlm.nih.gov/pubmed/2445967

[peachfuzz]

could somebody please dumb this down a little for me^ im really curious as to what the heck is being talked about. id really appreciate it.

[ni4ni]

SARMS x 3

[peachfuzz]

could somebody please dumb this down a little for me^ im really curious as to what the heck is being talked about. id really appreciate it.

what i think it is saying is that metabolites of the said hormones increase the effects of GABA (which from my understanding functions to inhibit neural transmission in the brain) and also inhibits t-butylbicyclophosphorothionate which serves to reverse the sedative effects of GABA while at the same time increases benzodiazepine flunitrazepam therfore even further increasing sedative effects. (wow i think i just confused myself)

this causes an inhibitory effect on normal physiological processes which can include muscle growth.

so in conclusion it is bad.

am i somewhat correct? havn't exactly had the formal education that some of you have.

if so then it falls along the lines of what i said i would like to see Merc write an article on.

[MuscleScience]

LOL, as any Hitchhiker's Guide knowledgeable person knows the answer is "42".

All kidding aside this is a very serious question with some significant ramifications, peripheral to which happens to be the answer to MS’s (I always liked this guy) present & extremely apt question:

There really is a very rational and comprehensible answer to both of our questions which has to do the two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone and 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10(-7) and 10(-5)M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons. These data may explain the ability of certain steroid hormones (and other contraindicative hormone related drugs like SERMs and AIs) to rapidly alter neuronal excitability and may provide a mechanism for the inhibiting actions of numerous naturally occurring bodiliy chemicals as well as, both synthetic anesthetic & "YES" believe it or not, similarly reactive anabolic steroid synthesis.

Merc,

Should you be so inclined, here are some of the central resources...

http://www.pubmedcentral.nih.gov/art...?artid=2042897
http://www.ncbi.nlm.nih.gov/pubmed/15282269
http://www.ncbi.nlm.nih.gov/pubmed/16702996
http://www.ncbi.nlm.nih.gov/pubmed/2598927
http://www.ncbi.nlm.nih.gov/pubmed/2888123
http://www.ncbi.nlm.nih.gov/pubmed/2445967

I bet if you and I were on pubmed at the same time we would crash their servers....LOL

Nice writeup btw!

[magic32]

I bet if you and I were on pubmed at the same time we would crash their servers....LOL

Nice writeup btw!

Ditto! LOL

if so then it falls along the lines of what i said i would like to see Merc write an article on.

There are similar implications.

-------------

Where are you at Merc???

[MASTER]

The potential of SARMS is definately something I am interested in. Potential in terms of use for pct/bridging and if they can be developed to have a pronounced anabolic effect (ie be used alone for good gains).

[jbm]

the potential of sarms is definately something i am interested in. Potential in terms of use for pct/bridging and if they can be developed to have a pronounced anabolic effect (ie be used alone for good gains).

x2...

[Narkissos]

Sup Nark?

Yeah Merc that is something I've been wondering about, but it bears some research. Could you write something about how a bioassay based on electrophysiological assessment of GABAA receptor function and optical measurements of cellular accumulation of a fluorescent steroid analogue suggest that γ-cyclodextrin sequesters steroids rather than directly influencing GABAA receptor function?

Or Nark if you just know it off hand please chime in.

Thanks.

the answer is...

A) 1/3

[stack_it]

I'd be interested in reading about the effect alcohol has on the ability to gain muscle and strength. I know alcohol minus the mixers has little to no calories so is it the dehydration that causes adverse effects or is it just that it usually effects the diet?

[Merc.]

LOL, as any Hitchhiker's Guide knowledgeable person knows the answer is "42".

All kidding aside this is a very serious question with some significant ramifications, peripheral to which happens to be the answer to MS’s (I always liked this guy) present & extremely apt question:

There really is a very rational and comprehensible answer to both of our questions which has to do the two metabolites of the steroid hormones progesterone and deoxycorticosterone, 3 alpha-hydroxy-5 alpha-dihydroprogesterone and 3 alpha, 5 alpha-tetrahydrodeoxycorticosterone, are potent barbiturate-like ligands of the gamma-aminobutyric acid (GABA) receptor-chloride ion channel complex. At concentrations between 10(-7) and 10(-5)M both steroids inhibited binding of the convulsant t-butylbicyclophosphorothionate to the GABA-receptor complex and increased the binding of the benzodiazepine flunitrazepam; they also stimulated chloride uptake (as measured by uptake of 36Cl-) into isolated brain vesicles, and potentiated the inhibitory actions of GABA in cultured rat hippocampal and spinal cord neurons. These data may explain the ability of certain steroid hormones (and other contraindicative hormone related drugs like SERMs and AIs) to rapidly alter neuronal excitability and may provide a mechanism for the inhibiting actions of numerous naturally occurring bodiliy chemicals as well as, both synthetic anesthetic & "YES" believe it or not, similarly reactive anabolic steroid synthesis.

Merc,

Should you be so inclined, here are some of the central resources...

http://www.pubmedcentral.nih.gov/art...?artid=2042897
http://www.ncbi.nlm.nih.gov/pubmed/15282269
http://www.ncbi.nlm.nih.gov/pubmed/16702996
http://www.ncbi.nlm.nih.gov/pubmed/2598927
http://www.ncbi.nlm.nih.gov/pubmed/2888123
http://www.ncbi.nlm.nih.gov/pubmed/2445967

Sorry for the delayed response .. I have had very little time to post on the board( it has been a busy few weeks)..

Very interesting Magic ...... This is going to give us some possible in site as to the cause of aggression when using certain AAS compounds..

As I am sure you know .. GABA regulates serotonin and the catacholmines ( L-dopa, norepinephrine , adrenaline )..

So the inhibition of GABA would have an effect on chemicals called serotonergic amines ( in the brain) which would decrease brain serotonin( which could/would cause aggression) .. As well as have a negative effect on dopamine ( which allows one to feel joy , and have energy)..

Since there aren't really any valid studies using compounds ( like tren , in humans) I think this could be a very good article and could give some great in site about neurotransmitters - increased aggression , depression and anxiety caused by GABA inhibition while using certain AAS ..


Merc.

[Merc.]

Thanks for the feedback guys ... Some great topics you came up with .. Sarms and pct keep coming up ....

Any More input ?? And anyone who is interested in contributing( writing a section ) in the article please hit me up ....


Merc.

[Merc.]

I would like to see some DOSAGE studies

as I believe more food is sometimes better then more steroids

Food is VERY anabolic .... thats a great topic also ...

Thanks T ...



Merc.

[magic32]

Hey Merc,

Is that the new fiance you've been raving about in your avie?

[HORSE]

Hey Merc,

Is that the new fiance you've been raving about in your avie?

Bump, I have been wondering the same thing since the day this thread was started....


Hope all is well D....