Our lifestyles, xenoestrogens and infertility, are we wiping ourselves of the planet?

[Nate_Dog]

FIRSTLY PLEASE EXCUSE THE TYPO IN THE TITLE OF THE THREAD, THE CORRECTION IS "OFF the planet".... sorry.. can't change it now! Ok.. on with the thread.

I recently had to do a short paper at Uni on "Technologies" and there effect on society. I thought this may be of interest here - specifically xenoestrogens. I thought this might evoke an interesting discussion

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With increasingly complex interactions of both direct and indirect pressures on human health and reproduction, the next century will surely provide many challenges for the future of humanity. Xenoestrogens, lifestyle choices and interference with genetic selection could have unforeseen and dire consequences. The purpose of this discussion is to explore the interactions of society and technology and how the combination of various factors could in the long‐term affect the survivability of the human race. The focus will be on specific chemicals, lifestyle choices, scientific technologies and their interaction. This essay will show that we have to seriously rethink our use of these related technologies and their impact to ensure a future where reproduction is possible.

Environmental chemicals known as xenoestrogens are presenting themselves as direct challengers to long‐term human reproduction in both the terms of increasing infertility and as carcinogenic agents. DDT and PCBs have been shown to have a strong estrogenic effect on wildlife and have long half‐lives of 60+ and 10+ years respectively (Toppari et. al. 1996, 748 ‐ 756). It has been expressed that these persistent organic pollutants “may undergo global scale redistribution” (Kalantzi et. al. 2001, 1013). This raises the concerns about their continual use in developing countries as posing a much larger global threat. Bisphenol A is commonly used in the manufacturing of plastic goods, food containers, toys, medical goods, plastic water bottles and lacquer coating in food cans (Vandenberg, et.al 2007, 140). In a study the canned foods and their associated liquids, both tested positive for xenoestrogens (Brotons et. al. 1995, 609). Perinatal exposure of certain levels of BPA has been shown to alter the fetus in ways that may predispose the child to future disease, reduced fertility and gender related cancers (Maffini et. al. 180). Parabens are xenoestrogens that are widely used internationally as preservatives in lotions, cosmetics, pharmaceuticals, food and contact lenses. (Darbre et. al. 2004, 5). Parabens have been observed to exhibit dose related decreases of both sperm and testosterone in rats. In this study a daily intake of Parabens in which a hormonal disruption was observed was within the acceptable daily upper‐limit as stated by the EU and Japan (Oishi 2002, 1811) and recent scientific literature also states that Parables may not be as safe as first thought (Tavares, Martins, Oliveira, Ramalho‐Santos, Peixoto 2009, 2). These environmental xenoestrogens pose a threat to the future of human reproduction in there own right, but individual lifestyles choices are also exposing people to situations that impact on their ability to reproduce.

Lifestyle choices can also impact seriously on an individual’s fertility. Living in a city with elevated levels of pollution and breathing poor quality air has been shown to have impacts on sperm quality in human males (Selevan, et. al. 2000, 887). This is not limited to the male but also fetal deaths, the following stated “a significant and robust association between air pollution and intrauterine mortality” (Pereira et. al 1998, 328). Moderate alcohol consumption has shown to have negative trends on sperm quality (Pajarinen et. al. 1996, 334). Cigarette smoking has been linked to low sperm density, especially in heavy smokers (Chia, Xu, Ong, Tsakok & Lee 1994, 292). The increasing use in laptop computers if used on the lap of male has raised concerns about increasing scrotal temperature and has been shown to have negative impacts on sperm maturation. Lifestyle choices have a definite link to male infertility. Are we wiping our selves out of the gene pool with poor lifestyle choices or is this just a modern incarnation of the evolutionary theory of survival of the fittest?

Survival of the fittest in the traditional sense, no longer seems to ring true in our society. What would have once been considered weak genes are now able to remain in the human gene pool due to advancements in medicine and society. Though one may question is this actual a good thing for the future of humanity or are we diluting the gene pool? Though fertility technology, males with defective sperm have been able allowed to reproduce. Through this process it is possible that the defective genes are passed onto the children (David et. al. 1999, 1722). This then presents as a temporary bandaid as opposed to a real solution. Allowing defective genes to survive is not only limited to the realms of fertility. Historically humans with colour defective vision faced challenges throughout evolution with survival and hunting. Through advancements in agriculture, outdated evolutionary style hunting was no longer a heavy requirement for survival. One would assume the inability to effectively read colours from the environment, is no longer a major challenge or threat to an individuals survival. The question then presents that is this really supportive of the long‐term survival of the human race? This avenue of science presents direct conflict with Darwin’s theory of natural selection.

Historically little was know about the long‐term effects of all of substances when they were originally released into the market place. Items once labelled “scientific breakthroughs” or considered totally safe have later presented to be the opposite. It is now well known that these each of these individual examples provided here present varying levels of opposition to human reproduction on varying levels. A concern is how little is known about their long‐term synergistic effects. Daily exposure to pollution, environmental chemicals, plastics, skin care products and laptops seem to a relatively unquestioned and common lifestyle norm. If our environment and lifestyle choices fail us along with it our fertility, having fertility science as a bandaid does not seem to be a viable solution. Overall it is concerning how little is know about the interaction of these “technologies”, substances and factors. Considering the common and increasing levels of exposure, it raises some serious concerns about the long‐term sustainability of the human race. A serious re‐evaluation of recently suspect technologies, future technologies, certain manufacturing processes, chemical usage, environmental waist and our lifestyles is needed to insure our long‐term survivability.

Refernces:

Brotons, J. A., M F Olea‐Serrano, M Villalobos, V Pedraza, and N Olea. 1995.Xenoestrogens released from lacquer coatings in food cans.Environmental Health Perspectives 103(6): 608–612.

Chia SE, Xu B, Ong CN, Tsakok FM, Lee ST. 1994. Effect of cadmium and cigarette smoking on human semen quality. International journal of fertility and menopausal studies, v39(5): 292‐298.

Darbre, P. D., A. Aljarrah, W. R. Miller, N. G. Coldham, M. J. Sauer and G. S. Pope. 2004. Parabens in Human Breast Tumors. Journal of Applied Toxicology 24: 5–13.

David C., Sherman Silber and Laura G. Brown. 1999. Men with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertility. Human Reproduction, v14(7): 1722‐1726.

Kalantzi, O. I., R. E Alcock, P. A. Johnston, D. Santillo, R. L. Stringer, G. O. Thomas, and K. C. Jones. 2001. The Global Distribution of PCBs and Organochlorine Pesticides in Butter. Environmental Science and Technology 35 (6): 1013–1018

Maffini, Maricel V., Beverly S. Rubin, Carlos Sonnenschein and Ana M. Soto. 2006. Endocrine disruptors and reproductive health: The case of bisphenol‐A.Molecular and Cellular Endocrinology 254–255: 179–186.

Oishi, S. 2002. Effects of propyl paraben on the male reproductive system. Food and Chemical Toxicology 40: 1807–1813.

Pajarinen, Jarkko., Pekka J. Karhunen, Vesa Savolainen, Kaisa Lalu, Antti Penttil, Pekka Laippala. 1996. Moderate Alcohol Consumption and Disorders of Human Spermatogenesis. Alcoholism: Clinical and Experimental Research, v20(2): 332‐337.

Pereira, L A., D Loomis, G M Conceição, A L Braga, R M Arcas, H S Kishi, J M Singer, G M Böhm, and P H Saldiva. 1998. Association between air pollution and intrauterine mortality in São Paulo, Brazil. Environmental Health Perspectives, v106(6): 325–329.

Selevan, Sherry G., Libor Borkovec, Valerie L. Slott, Zdena Zudova, Jir̆i Rubes̆, Donald P. Evenson and Sally D. Perreault. 2008. Semen Quality and Reproductive Health of Young Czech Men Exposed to Seasonal Air Pollution. Environmental Health Perspectives, v108(9): 887‐894.

Tavares, Renata S, Fátima C. Martins, Paulo J. Oliveira, João Ramalho‐Santos, Francisco P. Peixoto. 2009. Parabens in male infertility—Is there a mitochondrial connection? Reproductive Toxicology 27(1): 11‐7.

Toppari J, Larsen J, Christiansen P, Giwercman A, Grandjean P, Guillette L, Jégou B, Jensen TK, Jouannet P, Keiding N, Leffers H, McLachlan JA, Meyer O, Müller J, Rajpert‐De Meyts E, Scheike T, Sharpe R, Sumpter J, Skakkebaek NE. 1996. Male reproductive health and environmental xenoestrogens. Environmental Health Perspectives. v104: 741–803.

Vandenberg, Laura N., Russ Hauser, Michele Marcus, Nicolas Olea, Wade V. Welshons. 2007. Human exposure to bisphenol A (BPA). Reproductive Toxicology 24(2): 139‐177.

[Nate_Dog]

There was heaps of stuff that I couldn't fit in due to word my word, limit.. originally I had so much info written up on xenoestrogens, that I has exceeded my word limit.. just addressing that.

Things like international decrease in test levels, increased rates of testicular cancers, increased rate of children born with sexual deformities. I had papers coming out of my ass on this one.

Anyway... with ll these environmental estrogens in skin products, preservatives, pesticides, other environmental pollutants, I mean basically in EVERYTHING... can anyone blame up for sex medicating our own natural sex hormones?

Poliquin said that all the coaches he spoke to, all agreed even with advances sciences today, it was easier to get people bigger 30 years ago. All the shit in the environment combined with stress is a major reproductive nightmare.

Give it 50 years and everyone will be permanentally be on PCT drugs..

[kalspic]

nice read, very interesting.

[Narkissos]

What's up with all these anti-estrogens?
What's up with all these anti-estrogens?

[JiGGaMaN]

i stopped reading when you started with FIRSTLY.

[warchild]

me too

[Nate_Dog]

i stopped reading when you started with FIRSTLY.

Why bother posting then.. ?

It was a correction of title of the thread as there was a typo and I couldn't change it after I posted it....

Frankly (maybe you don't like that one either)... I wanted the thread to be an intelligent discussion.. so maybe it is best you that you didn't post considering the limited scope of your last post. And without offending anyone.. if you haven't got anything intelligent to add to the thread... please don't bother posting.

For people that have access to information, knowledge of, or experience with xenoestrogens, reproductive medicine, or or are educated on the topic (or just well educated in general) etc then I would love to hear from you guys.

Thanks,
Nate.

[JiGGaMaN]

Why bother posting then.. ?

It was a correction of title of the thread as there was a typo and I couldn't change it after I posted it....

Frankly (maybe you don't like that one either)... I wanted the thread to be an intelligent discussion.. so maybe it is best you that you didn't post considering the limited scope of your last post. And without offending anyone.. if you haven't got anything intelligent to add to the thread... please don't bother posting.

For people that have access to information, knowledge of, or experience with xenoestrogens, reproductive medicine, or or are educated on the topic (or just well educated in general) etc then I would love to hear from you guys.

Thanks,
Nate.

my intelligent comment was that its probably not that intelligent of a post if the person starts off with 'firstly', which is indicative of grammatical incompetence.

[jimmyinkedup]

^^^ oh for christs sake jigga that kind of arrogance breeds ignorance ... gimme a break !

[JiGGaMaN]

^^^ oh for christs sake jigga that kind of arrogance breeds ignorance ... gimme a break !

hey, i want the best from my forum friends. im here to help, and from time to time i come across as a dick, for no real good reason.


To the OP: if you havent handed it in yet, ill pm you a proofread copy with suggestions, and for all future papers, i can do the same. Many of my colleagues mark undergrad level papers regularly, so i have inside info on how to get a better mark every time.

What course/level was this submitted for?

[jimmyinkedup]

^^ i know jigga...not all have been around u long enough to understand your demeanor or your intentions! Hell u surely rubbed me the wrong way for a while when i got here ..till i got a feel for your sarcasm / humor ..etc....
No personal offense intended ...just a roundabout ease up i suppose.... eh whatever...

[JiGGaMaN]

^^ i know jigga...not all have been around u long enough to understand your demeanor or your intentions! Hell u surely rubbed me the wrong way for a while when i got here ..till i got a feel for your sarcasm / humor ..etc....
No personal offense intended ...just a roundabout ease up i suppose.... eh whatever...

it just gets lost in translation most of the time. but then again, we are on a steroid forum, so fuses are not as long as they should be a lot of the time. that paper is a lot better than what i saw from the 3rd year students my friend was marking. some of it is just unbelievable. there was one paper submitted, ive never laughed so hard. it was on domestic violence and the title was "Dating violence: The silent perpetuator". anyhow, the conclusion was "We cant let bad things happen to these girls!" he got a passing grade just because it was so funny to read.

[Nate_Dog]

hey, i want the best from my forum friends. im here to help, and from time to time i come across as a dick, for no real good reason.


To the OP: if you havent handed it in yet, ill pm you a proofread copy with suggestions, and for all future papers, i can do the same. Many of my colleagues mark undergrad level papers regularly, so i have inside info on how to get a better mark every time.

What course/level was this submitted for?

Only entry level... this is you know how you do a bullshit subject as an intro.. well I decided on technology and society.. but that was one of my intro subjects..

Though in posting it - I am not concerned with my actual paper or some of my typos (it has been and graded already) but more about the topic and if anyone is interested in accessing the reference information, hence why I posted it. It was supposed to stimulate a conversation. It has,,.. but not the kind I expected.

Steroid forum or not,... I would like to think that there are informed, reflective and intellectual juicers out there, god knows we have a bad rap as it is... and I have met a lot of dumb asses in the gym in my time.

Also gearers or not, I believe and the research supports that this stuff is of serious concern. I am thinking about having a kid soon with my wife and I wonder how much more we will **** things up in the next 50 years (hence my other paper on peak oil and oil dependency).

I think people come home at night, turn on cable and are blissfully unaware of how ****ed things are. Maybe if the media stopped pumping the news with bullshit steroids etc and started providing some real news that is of value, people might wake up.

I ****ing hate the TV,... for the most part I believe it caters (in my mind) to small minded, unaware and poorly informed people.. that get spoon fed life and "reality" through a box.

[jbm]

my eyes hurts... lololol!!!! J/K

[Nate_Dog]

my eyes hurts... lololol!!!! J/K

Lets just talk about ****ing instead..?

[jbm]

lolol! for tired and dry eyes!

[Nate_Dog]

Old ass traffic.. my mate loves that site..

[jrmy]

nate,good post.ive recently heard about this(the bpa concern)and i wonder why the fda allows for this yet congress bans aas.i drink and eat from plastics everyday,so of course this is a concern for me.Ironically,i also have hip fat like a women.not severe but its ther..almost an hr glass figure....and minor breast tissue.only two damn places i have fat!!!health insurance soon to come to get blood levels checked(rather pay health insurance than rip off online test)would this be the cause??who knows,but soon i will.
ive also read and seen vids about how the elite and powerful is trying to cut the world population by 80 percent...by chemicals such as aspartame,bpa,and fluoride.its a debate ill tell you that.id rather order some aromasin ,then get on nolvadex if i had the money.in the meanwhile,i will switch to glass containers.what would you suggest nate?or should i wait till i get the hormones checked out?