**Marcus's HIT Dungeon**

[InternalFire]

AG, which form of vit K are you referring to? Ive been taking good dose of K2 MK7 at first for several months but thats sinthetic version hence need megadosing and lasts very short in the system, then switched to lifeforce K2 complex that has K2 mk4 mk7 and K1, more long acting K2 in general

[Sfla80]

Morning everyone


Chest soon here, and docs after the gym. I know she's gonna order mri now since still in pain which sucks. Tired of medical bills .

Anyways kill it everyone.

Report back later

[marcus300]

Morning everyone


Chest soon here, and docs after the gym. I know she's gonna order mri now since still in pain which sucks. Tired of medical bills .

Anyways kill it everyone.

Report back later

Lets us know how you go mate ?

[NACH3]

Morning everyone


Chest soon here, and docs after the gym. I know she's gonna order mri now since still in pain which sucks. Tired of medical bills .

Anyways kill it everyone.

Report back later

GL with the doc Brotha!

[Sfla80]

Lets us know how you go mate ?

Definitely marcus.

Not sure if u notic3d my previous post or not. So when I am doing chest with dbs. When I throw the weight up with the knee electric shock/pain runs straight from lower back throughout my left leg.

Now have constant pain in knee as well.

[Sfla80]

GL with the doc Brotha!

Thanks nach. Still gonna tear some chest up lol

[marcus300]

Definitely marcus.

Not sure if u notic3d my previous post or not. So when I am doing chest with dbs. When I throw the weight up with the knee electric shock/pain runs straight from lower back throughout my left leg.

Now have constant pain in knee as well.

fucking hell, best of luck doesn't sound good though. Its the game we are in seems to come along with the territory

[NACH3]

Thanks nach. Still gonna tear some chest up lol

I know that feeling haha - just be careful buddy!

Listen to me - I can barely move and telling you to take it easy lmao

[almostgone]

AG, which form of vit K are you referring to? Ive been taking good dose of K2 MK7 at first for several months but thats sinthetic version hence need megadosing and lasts very short in the system, then switched to lifeforce K2 complex that has K2 mk4 mk7 and K1, more long acting K2 in general

My cardiologist just had me minimize my intake of Vitamin K in general. Had me go easy on the greens although she did say the occasional cup of green tea was ok because the typical amount ingested was down in the mcg range.
It's just a precaution I have to take because I form blood clots very easily. They had me on Arixtra, which is very similar to a low molecular weight heparin, but they didn't want me on it long term due to the side effects. Coumadin literally has no effect on my PT/INR. LOL, there were several times they couldn't even check my PT/INR at the coumadin clinic. The sample was clotted before it ever made it to the meter (they use a doohickey that looks somewhat like a glucomoeter).
Also they wanted me to have an IVC filter but I refused after having staph eat me up (literally my blood was loaded with it) and the pacemaker I had was removed so the staph could be cleared from my system.
Kind of glad I didn't get the IVC. They have commercials on TV all of the time for lawyers looking to make a $ off of people that have an IVC. .
Hope that answered your question, IM.

[almostgone]

Morning everyone


Chest soon here, and docs after the gym. I know she's gonna order mri now since still in pain which sucks. Tired of medical bills .

Anyways kill it everyone.

Report back later

Best of luck, Sfla!

[almostgone]

I know that feeling haha - just be careful buddy!

Listen to me - I can barely move and telling you to take it easy lmao

LOL, easier said than done.

[BG]

Guy at the gym said to me I was a big fucking meat head so I took that as a compliment rather than an attack and let him go.

Priceless.....say "Thanks matea' and smile.

The one I get when kids are near me and I only have one ear bud in " I wouldn't want to be that big"....I just look over and say sure buddy.

[NACH3]

LOL, easier said than done.

Haha it sure is, AG! LOL

[NACH3]

Priceless.....say "Thanks matea' and smile.

The one I get when kids are near me and I only have one ear bud in " I wouldn't want to be that big"....I just look over and say sure buddy.

They couldn't even train the way you are with all the damn supps in the world... It's called Discipline and you sir have it!

[marcus300]

Just picked up my trt shot and injected 4ml of this beautiful oil into my glute

[InternalFire]

Just picked up my trt shot and injected 4ml of this beautiful oil into my glute

https://postimage.org/

Marcus...

[Cuz]

Just picked up my trt shot and injected 4ml of this beautiful oil into my glute

How long has that been around Marcus i havent seen that until the other day looking thru here?

[kelkel]

The one I get when kids are near me and I only have one ear bud in " I wouldn't want to be that big"....I just look over and say sure buddy.

Big, scary fvck.

[marcus300]

How long has that been around Marcus i havent seen that until the other day looking thru here?

I take it every 12 weeks now

[marcus300]

Marcus...

yes?

[Cuz]

I take it every 12 weeks now

Ahh hence the 1000mg concentrate..thanks.

[almostgone]

Priceless.....say "Thanks matea' and smile.

The one I get when kids are near me and I only have one ear bud in " I wouldn't want to be that big"....I just look over and say sure buddy.

Bet I know why. They don't want to call up the discipline and dedication it takes to work that hard.

[marcus300]

New study on the Nebido site 15May 2016, interesting indeed

Survival and cardiovascular events in men treated with testosterone

Survival and cardiovascular events in men treated with testosterone

Survival and cardiovascular events in men treated with testosterone replacement therapy: an intention-to-treat observational cohort study. Wallis CJD, Lo K, Lee Y, et al. The Lancet Diabetes & Endocrinology. 2016;May 7

On the surface, testosterone therapy is a controversial treatment because previous studies investigating the effects of testosterone therapy have been conflicting, with some studies showing supposed harm and others showing significant benefit.

Here we present the results of a new study published in The Lancet Diabetes & Endocrinology on May 7 2016, which addressed some shortcomings in previous studies by analyzing effects based on duration of testosterone treatment.1
.

KEY POINTS

After a follow-up for over 5 years, men treated with testosterone had 12% lower mortality than non-testosterone treated men.
Compared to non-testosterone treated men, men with the shortest duration of testosterone treatment had 11% increased risk of mortality and 26% increased risk cardiovascular events. In contrast, those with the longest duration of testosterone treatment had 33% decreased risk of mortality and 16% decreased risk of cardiovascular events.
Risk of prostate cancer diagnosis was decreased by 40% in men with the longest duration of testosterone treatment, compared to non-testosterone treated men. No effect on prostate cancer risk was seen among men with shortest duration of testosterone treatment.
It is speculated that the increased risk of cardiovascular events and mortality for men with the shortest duration of testosterone treatment could be driven by the consequences of underlying testosterone deficiency and inadequate treatment, rather than the testosterone treatment.
.

What is known


The health consequences of testosterone deficiency, and the benefits of its treatment - such as improvement in sexual function, mood, body composition and metabolic risk factors - are well established in medical research.2 Despite this, testosterone therapy is controversial. Concerns regarding cardiovascular risk were based on two deeply flawed retrospective studies, which we discussed in a previous editorial “Testosterone Therapy and Cardiovascular Risk - Advances and Controversies”.

Despite the multiple flaws of these two studies, they led the US Food and Drug Administration (FDA) to issue a warning that testosterone therapy might increase risk of heart attack and stroke.3

This supposed harm is strongly refuted by many studies showing cardiovascular benefits of higher endogenous testosterone as well as testosterone therapy, including placebo-controlled studies in men with known heart disease (angina, heart failure).4,5 In addition, 3 large meta-analyses have refuted a supposed causal role between testosterone therapy and adverse cardiovascular disease events.6-8 To the contrary, in randomized controlled trials – the gold standard study type in medical research - performed in subjects with metabolic derangements (which constitute about half of the general population9-12) a protective effect of testosterone therapy on cardiovascular disease risk was observed.7 More recently, numerous additional observational studies have confirmed that low testosterone levels are associated with heart disease and that testosterone therapy confers beneficial effects, or is at worst neutral in terms of cardiovascular disease outcomes and mortality.1,13-17
.

What this study adds


The Lancet study sought to assess the effect of testosterone therapy on overall mortality and cardiovascular events in men with long-term follow-up using a time-varying testosterone exposure, in order to find out if duration of testosterone treatment impacts outcomes. Prostate cancer was also examined because testosterone therapy has historically been considered a risk factor for developing prostate cancer, even though recent studies have disproved this (see comment below).

10,749 men aged 66 years or older who were treated with testosterone therapy were matched for age, comorbidity, diabetes, region of residence, with 28,029 controls (i.e. men who did not receive testosterone therapy). The study assessed the effect of testosterone therapy in two ways; testosterone treatment as a dichotomous variable (any or never), and total testosterone treatment duration (cumulative testosterone exposure) divided into groups of 1-3 months, 6-12 months and 25-51 months. Testosterone treatment duration was measured by the total number of days of testosterone therapy dispensed according to prescription records.

The primary outcome was overall mortality. Secondary outcomes were a composite cardiovascular outcome (comprising heart attack, stroke, or blood clot) and prostate cancer diagnosis.

When the effect of testosterone therapy was examined as a yes or no variable, 5-year mortality was significantly lower in men treated with testosterone therapy (15.4%) than in controls (17.7%).

To examine the effect of testosterone treatment duration, men were divided into three groups; lowest, middle and highest testosterone treatment duration. Men with the lowest group had higher mortality than controls, but those in the middle and highest groups had lower mortality than controls. The risk of mortality was progressively lower with increasing duration of testosterone therapy, with a significantly decreased risk for men who had been treated with testosterone for the longest duration.

5-year incidence of cardiovascular events did not differ significantly between testosterone treated men and controls, but the 5-year incidence of prostate cancer diagnoses was 14% lower in the testosterone treated men.

When analyzing the results based on testosterone treatment duration, men who had been on testosterone for the shortest duration had a 26% higher incidence of cardiovascular events than did controls, but men who had been on testosterone for the longest duration had 16% lower incidence than controls. Similarly, men who had been on testosterone for the shortest duration had the equivalent rates of prostate cancer diagnosis to controls, whereas those who had been on testosterone for the longest duration had 40% less prostate cancer diagnoses than controls.
.

Comments


This study is the first study to assess the effect of different durations of testosterone therapy on mortality and cardiovascular events. The results of this analysis explain previous conflicting findings of the effect of testosterone therapy on cardiovascular events.

With a large number of subjects and long duration of follow-up, long-term testosterone therapy was found to reduce both mortality, cardiovascular events and prostate cancer, while short-term testosterone therapy may increase mortality and cardiovascular events. Thus, if there is short-term risk, it dissipates over time with ongoing treatment.

In a previous study that showed increased risk of myocardial infarction after initiation of testosterone therapy, treatment duration and follow-up were limited to only 90 days. The study by Etminan et al. also found a small increased risk of heart attack in first-time users.18 However, as the absolute risk was low, the clinical significance of this minor risk increase is questionable.

It has been documented that full expression of the effects of testosterone therapy take many years.19 Considering the well-documented adverse health effects of testosterone deficiency2,20-22, the authors of this study appropriately suggest that the reason for the increased rates of cardiovascular events and mortality in the short-term treatment group could be driven by the consequences of underlying testosterone deficiency and inadequate treatment, rather than the testosterone treatment.

This study also confirms the safety of testosterone therapy in terms of prostate cancer.

See our related editorial on prostate cancer and adverse health effects of testosterone deficiency:

Testosterone and Prostate Cancer - a paradigm shift
Adverse health effects of testosterone deficiency in men
.

References

1. Wallis CJ, Lo K, Lee Y, et al. Survival and cardiovascular events in men treated with testosterone replacement therapy: an intention-to-treat observational cohort study. The Lancet. Diabetes & Endocrinology. 2016.
2. Traish AM. Adverse health effects of testosterone deficiency (TD) in men. Steroids . 2014;88C:106-116.
3. Moeny D, Staffa J. Joint meeting for bone, reproductive and urologic drugs advisory committee (BRUDAC) and the drug safety and risk management advisory committee (DSARM AC): the potential for adverse cardiovascular outcomes associated with use of TRT. US Food and Drug Administration: Sept 17, 2014.
4. Morgentaler A. Controversies and Advances With Testosterone Therapy: A 40-Year Perspective. Urology. 2016;89:27-32.
5. Morgentaler A, Miner MM, Caliber M, Guay AT, Khera M, Traish AM. Testosterone therapy and cardiovascular risk: advances and controversies. Mayo Clin. Proc. 2015;90(2):224-251.
6. Corona G, Maseroli E, Maggi M. Injectable testosterone undecanoate for the treatment of hypogonadism. Expert opinion on pharmacotherapy. 2014:1-24.
7. Corona G, Maseroli E, Rastrelli G, et al. Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis. Expert opinion on drug safety. 2014;13(10):1327-1351.
8. Corona GG, Rastrelli G, Maseroli E, Sforza A, Maggi M. Testosterone Replacement Therapy and Cardiovascular Risk: A Review. The world journal of men's health. 2015;33(3):130-142.
9. Ford ES, Li C, Zhao G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. Journal of diabetes. 2010;2(3):180-193.
10. El Brini O, Akhouayri O, Gamal A, Mesfioui A, Benazzouz B. Prevalence of metabolic syndrome and its components based on a harmonious definition among adults in Morocco. Diabetes, metabolic syndrome and obesity : targets and therapy. 2014;7:341-346.
11. Botoseneanu A, Ambrosius WT, Beavers DP, et al. Prevalence of metabolic syndrome and its association with physical capacity, disability, and self-rated health in Lifestyle Interventions and Independence for Elders Study participants. J. Am. Geriatr. Soc. 2015;63(2):222-232.
12. Yang L, Colditz GA. Prevalence of Overweight and Obesity in the United States, 2007-2012. JAMA internal medicine. 2015;175(8):1412-1413.
13. Anderson JL, May HT, Lappe DL, et al. Impact of Testosterone Replacement Therapy on Myocardial Infarction, Stroke, and Death in Men With Low Testosterone Concentrations in an Integrated Health Care System. Am. J. Cardiol. 2016;117(5):794-799.
14. Baillargeon J, Urban RJ, Morgentaler A, et al. Risk of Venous Thromboembolism in Men Receiving Testosterone Therapy. Mayo Clin. Proc. 2015;90(8):1038-1045.
15. Patel P, Arora B, Molnar J, Khosla S, Arora R. Effect of testosterone therapy on adverse cardiovasular events among men: a meta-analysis. J. Am. Coll. Cardiol. 2015;65(March).
16. Saad F, Haider A, Haider KS, Doros G, Traish AM. Obese Hypogonadal Men with Cardiovascular Diseases (CVD) Benefit from Long-Term Treatment with Testosterone Undecanoate (TU): Observational, Real-Life Data from a Registry Study. Male Hypogonadism - Causes and Treatments. Vol March 72015:SAT-135-SAT-135.
17. Sharma R, Oni OA, Gupta K, et al. Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Eur. Heart J. 2015;36(40):2706-2715.
18. Etminan M, Skeldon SC, Goldenberg SL, Carleton B, Brophy JM. Testosterone therapy and risk of myocardial infarction: a pharmacoepidemiologic study. Pharmacotherapy. 2015;35(1):72-78.
19. Saad F, Aversa A, Isidori AM, Zafalon L, Zitzmann M, Gooren L. Onset of effects of testosterone treatment and time span until maximum effects are achieved. Eur. J. Endocrinol. 2011;165(5):675-685.
20. Traish AM, Guay A, Feeley R, Saad F. The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction. J. Androl. 2009;30(1):10-22.
21. Traish AM, Saad F, Guay A. The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance. J. Androl. 2009;30(1):23-32.
22. Traish AM, Saad F, Feeley RJ, Guay A. The dark side of testosterone deficiency: III. Cardiovascular disease. J. Androl. 2009;30(5):477-494

[marcus300]

Ahh hence the 1000mg concentrate..thanks.

yes its that new therapy for trt well its not new its been studied for years but its an extremely long ester what keeps your blood values even for a long time, also in the higher end range, lovely product and less injection. Also I like the volume especially when I inject it into my bicep M

[BG]

They are just full of shit, I walk in to use the bathroom with their shirts off looking in the mirror, I just laugh, piss and then fart as loud as I can

[BG]

seemed to have an assload of BA in it, so I passed.

Did it cause pain? Because something in the mixing solution for hcg and GH give me weird reaction and my face gets real red. I changed to bac water and no issues.

[almostgone]

6 egg whites, just a tad of spinach, and 1 oz of mozzarella all scrambled together and a big bowl of oats coming up.
Will down a cup of FF plain Chobani with some sliced fresh strawberries here in a few hours. How the sleep goes well today. I miss my weights.

[marcus300]

...............................

happy ive got myself reviewed on this again for another 12 months zero pain, no matter where you shoot it even in the outer or inner bicep of 4ml, goes in and stays in and does what its suppose to do. I am so

[almostgone]

Did it cause pain? Because something in the mixing solution for hcg and GH give me weird reaction and my face gets real red. I changed to bac water and no issues.

As best as I can remember BG, it was cyp and it stung like a madman. No knotting at the injection site to speak of, but I swear it felt like I was shooting isopropyl alcohol.

[BG]

As best as I can remember BG, it was cyp and it stung like a madman. No knotting at the injection site to speak of, but I swear it felt like I was shooting isopropyl alcohol.

Thats sucks, I havent shot a burner in a long time.

[almostgone]

Thats sucks, I havent shot a burner in a long time.

Yes sir, not fun at all. When my Dr. starts me on self injections, I'd love to get Pfizer, but at my CVS all they usually have is Watson and Sun Pharma.One of the pharmacists that I went to high school with said she would try to help me out when I get my script. Wasn't sure is she could get Pfizer depo run through my insurance cheaply, but would try to stock it if it ran through. Pfizer is just nice and light.

[almostgone]

Ok, guys and dolls, bedtime here. Time to sleep and dream of lots or pulldowns, rows, and deads.

[NACH3]

6 egg whites, just a tad of spinach, and 1 oz of mozzarella all scrambled together and a big bowl of oats coming up.
Will down a cup of FF plain Chobani with some sliced fresh strawberries here in a few hours. How the sleep goes well today. I miss my weights.

6whole eggs scrambled w/a big bowl of oats

Shk in between - nana oats PB 2scoops whey

Second breakfast here
5HB eggs(totalling 11) mixed fruit bagel
Coffee

[NACH3]

yes its that new therapy for trt well its not new its been studied for years but its an extremely long ester what keeps your blood values even for a long time, also in the higher end range, lovely product and less injection. Also I like the volume especially when I inject it into my bicep M

How long did it take you to get to steady state levels like th ones you have... Your TT is off the fuckin charts at your trough - I like

[NACH3]

Thats sucks, I havent shot a burner in a long time.

Oh that type of Burner LOL

Had me thinkin' ya offed someone lmao

[marcus300]

How long did it take you to get to steady state levels like th ones you have... Your TT is off the fuckin charts at your trough - I like

took along time may be around the 3-5th shot then I was stable and it stayed stable...

[marcus300]

Oh that type of Burner LOL

Had me thinkin' ya offed someone lmao

some sus is clean and some cyp in the uk is sloth as fuck

[NACH3]

some sus is clean and some cyp in the uk is sloth as fuck

Mmmmm & ugh lol

[marcus300]

Mmmmm & ugh lol

no both pharma

[NACH3]

no both pharma

No sh!t! I figured coming from you