I have only shot in my quads with 25g 1 in and don't know if i have the balls to try a 21g in the glute, but i dont realy have the option. It is a long story, but i either have to drive 8 hrs, or shoot in the glute with 21g, i hate needels btw. everytime it still sucks stickin myself. Big difference in the poke, or no?![]()