
Originally Posted by
SexyKitty
Sorry had to throw my 2 cents in, but if your gonna use a TZD....use actos (pioglitazone) instead of Avandia (rosiglitazone). Both of them work the same way....ie they reduce insulin resistance, and allow the body to use it's own circulating insulin more effetively. However, Avandia should be taken twice daily to be effective and is known to increase LDL (bad cholesterol) whereas Actos is a once daily drug and helps to lower triglycerides, increase HDL (good cholesterol) and has no effect on LDL. Be cautious however as both of these drugs can potentially increase liver enzymes (ALT specifically).
Also keep in mind that both actos and avandia work at the cellular level so they take about 4-6 weeks before they even start to work, you may probably want to stick to insulin since you will need fast results. Metformin is not a great choice, 90% of its effectiveness comes from reducing hepatic glucose output and it loses efficacy pretty quickly....plus it causes big time gas and stomach upset.