This is an article from Muscular Development from the Building The Perfect Beast Column
Q: In your books Chemical Muscle Enhancement and building the perfect beast you say anavar doesn't negativley effect the HPTA i heard about a study that proves it does in olnly a few days is this something you disagree with?
A: Hmmm, so you feel that oxandrolone (anavar) is inhibitive to the HPTA itself? interesting. Or may it may be a matter of matter of not understating what the HPTA refers to.
Why would anyone care if the HPTA did anything?
The HPTA is the group of glands that directly regulates the amount of androgens and sperm the male produce The hypothalamus secretes GnRH When GnRH meets up with the pituirtary gland it tells it to release LH and FSH Then LH and FSH act as chemical messengers that tell the testes to produce androgens and sperm if we do not have androgens or sperm we do not have muscle or sex
What directly regulates the hpta?
For the most part we are aware that the HPTA is regulated to the greatest extent by estrogen levels in the bodys blood circulatory system and we know most anabolic androgenic steroids aromatize to estrogens to some degree or have some estrogenic nature themselves thus we use the specific degree of aromatization and the prime deciding factor in regard to HPTA supressing potential for any AAS in short more estrogen means less natural testosterone and sperm production
Oxandrolone does not aromatize to estrogens and is therefore not directly inhibitive or suppresive to HPTA function I have monitored many hrt recipients who only used oxandrolone for prolonged periods with few exceptions these individuals maintained 60% or more normal HPTA activity since weekly LH and FSH fluctuations can sometimes be 50% +or- normal for any individual this is not a true sign of direct HPTA suppresion these individuals also have lower than normal estrogen levels due to no accumalative estrogen from aromatization with post oxandrolone use the return of normal LH and FSH is fairly quick
LH levels decrease with non aromatizing AAS due to increased neuronet activity this is a common effect of dht and its derivatives such as oxandrolone this is not HPTA suppresion due to a true negative feedback loop but rather neuronet overload in short the HPTA stands for Hypothalamus Pituitary Testes Axis. Not to be a smart ass but there is no N for neuro-net in HPTA
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Originally Posted by bignatt
