proof of bone growth closure?

**youngone17** · 03-24-2002, 03:10 PM

is there any actual solid proof that anabolics close growth plates?
i know that people say that but has it actually been proven?

**Dr.Evil** · 03-24-2002, 05:11 PM

yes

**Dr.Evil** · 03-24-2002, 05:15 PM

estrogen has been proven time and time again to be the catalyst for regulating epiphyseal plate (bone plate) closure. even if you take steroids that don't aromatize into estrogen, there will still be a large estrogen spike after your cycle is over to try to balance out your hormone levels.

there are better studies to show this, but this is the first one i found just now.

J Mol Endocrinol 2001 Oct;27(2):249-53

Expression of aromatase in the human growth plate.

Oz OK, Millsaps R, Welch R, Birch J, Zerwekh JE.

Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

Aromatase catalyzes the synthesis of estrogen from its androgen precursors. Estrogen is known to be important in regulating long bone growth and epiphyseal plate closure. To assess whether there may be growth plate-specific production of estrogen, we performed reverse transcriptase polymerase chain reaction (RT-PCR) to determine whether aromatase transcripts are present in the human growth plate. Immunohistochemistry was also employed to identify the specific sites of expression. Growth plates were obtained from an adolescent male and female undergoing ephysectomy to counter premature growth plate closure in the opposite leg. Aromatase transcripts were detected in RNA preparations from both growth plates. The aromatase protein was mainly expressed in the zone of maturation and the hypertrophic zone, with greatest expression in the latter. Since estrogen receptors are known to be expressed in chondrocytes, this data is consistent with a role for local estrogen production in the autocrine/paracrine control of long bone growth and growth plate maturation.

**youngone17** · 03-24-2002, 05:23 PM

but will one anabolic close bone growth quicker than another?
and if that is true about every one converting to estrogen than why do they use anavar in dwarf to stimulate bone growth?

**youngone17** · 03-24-2002, 05:49 PM

how long is that estrogen spike after your cycle? couldnt you just keep taking nolvadex like 2 weeks or more after your cycle to cope with that spike?