
Originally Posted by
Starkraven
i read those but a question, this one:
"Femara (AKA Letrozole), is more effective than Arimidex in it's ability to pass thru the cell membrane of lipid (fat) cells and inhibit the activity of aromatase -- Arimidex is just over 80% effective at inhibiting aromatase, Femara is around 95-97% Levels of estrogen are totally undetectable in any patients taking Letrozole, and it has even been used to increase testosterone to normal levels (from sub-normal ones) and increase LH, FSH and SHBG (Epilepsy Behav. 2004 Apr;5(2):260-3). Other than that, both of these drugs stop the process of aromatization, rather than just blocking (competing for, if you prefer) the receptors as Clomid and Nolvadex do. An effective dose of Letrozole is 1-2.5 mg/day (I use 1mg/day), but be forewarned, it can kill your sex drive, and could decrease IGF levels. On the other hand, I've seen studies where it increases IGF levels. Also worth noting is that there's a rebound effect when you come off Letrozol. What can I say? Letrozole's effects on serum lipids (cholesterol, both HDL and LDL) are, in the words of one researcher: "inconsistent. "And compared with Aromasin and Arimidex, In non-cellular systems, letrozole is 2-5 times more potent than anastrozole and exemestane in its inhibition of the aromatase enzyme and activity, and in cellular systems it is 10-20x more potent! Letrozole (2.5mg daily) also achieved a much greater suppression of the plasma concentrations of both estrone and estrone sulphate (estrogens) than anastrozole (1mg daily) and a greater inhibition of in vivo aromatization also (sorry for the geek-speak.it's over for now.). ( J Steroid Biochem Mol Biol. 2003 Oct;87(1):35-45.)"Finally, you need to take Letrozole for 60 days to get a steady blood plasma level, and it has a whopping 2-4 day (!) ½ life (Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S.). "
Letrozole can also be used in really small amounts...in fact, you can achieve maximum suppression of aromatase at a mere 100mcg (thats not a typo) per day!
( J Clin Endocrinol Metab. 1995 Sep;80(9):2658-60. )
In addition,
It would seem that you can get by on .5mgs/day...or less! And, just like myself (and Lion) have been saying...you can probably (maybe?) use it to combat both estrogen and progesterone! Yeah...it's an anti-progestin, an anti-estrogen, and an aromatase inhibitor....! And finally, not only can it suppress aromatazation and reduce estrogen levels, but it may even reduce progesterone levels (it did so in tumors in one study, any way)
(
Eur J Obstet Gynecol Reprod Biol. 2002 Nov 15;105(2):161-5. )
IT STATES IT CAN BE USED TO INCREASE TEST TO NORMAL LEVELS? so why use nolva/clomid? also just to note, my balls never shrank, im not completely limp, but my sex drive is lower, etc.
so the proper PCT is l-dex,nolva/clomid. can i use letro instead of l-dex? i just got letro and dumped my l-dex so....