Dostinex (cabergoline)
Trade Name Strength Container Manufacturer
Dostinex 0.5 mg Pharmacia & Upjohn
Class: Anti-Parkinson’s Agent and Dopamine agonist
Half-Life: 63 to 69 hours (i.e. nearly three days)
General Information: Cabergoline is a long acting D-2 dopamine receptor agonist. It is used primarily to treat hyperprolactemia disorders and as an adjunct therapy in Parkinson’s disease. Like its predecessor, Parlodel (bromocriptine), it is an ergot alkaloid structure. In athletics, cabergoline is used to treat progesterone induced gynecomastia from a heavy steroid cycle that results in progesterone conversion rather than the usual estrogen conversion. Examples of such steroids include Deca-Durabolin (nandrolone) and Fina (trenbolone). While Nolvadex and Clomid work effectively on estrogen, they are ineffective against progesterone and cabergoline or Parlodel (bromocriptine) must be used.
Uses: Cabergoline is dosed at 0.25mg every three days (or twice a WEEK). Remember this is a powerful drug with a very long half-life. The dose may be increase to 0.5mg twice a week, but for progesterone induced gynecomastia, 0.25mg twice a week should be sufficient.
Cautions: Side effects of cabergoline include: headache, dizziness and nausea in greater than 10% of all users. 1 to 4% experienced hot flashes, or peripheral edema (swelling in the limbs), GI upset, fatigue/drowsiness, and/or nasal congestion. The side effects usually subside after several doses.