Binding affinities of various AS

**Dr.Evil** · 04-19-2002, 11:27 AM

Endocrinology 1984 Jun;114(6):2100-6

Relative binding affinity of anabolic -androgenic steroids : comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.

Saartok T, Dahlberg E, Gustafsson JA.

It is unclear whether anabolic steroids act on skeletal muscle via the androgen receptor (AR) in this tissue, or whether there is a separate anabolic receptor. When several anabolic steroids were tested as competitors for the binding of [3H]methyltrienolone (MT; 17 beta-hydroxy-17 alpha-methyl-4,9,11-estratrien-3-one) to the AR in rat and rabbit skeletal muscle and rat prostate, respectively, MT itself was the most efficient competitor. 1 alpha-Methyl-5 alpha-dihydrotestosterone (1 alpha-methyl-DHT; mesterolone) bound most avidly to sex hormone-binding globulin (SHBG) [relative binding affinity (RBA) about 4 times that of DHT]. Some anabolic-androgenic steroids bound strongly to the AR in skeletal muscle and prostate [ RBAs relative to that of MT: MT greater than 19-nortestosterone ( NorT ; nandrolone ) greater than methenolone (17 beta-hydroxy-1-methyl-5 alpha-androst-1-en-3-one) greater than testosterone (T) greater than 1 alpha-methyl-DHT]. In other cases, AR binding was weak (RBA values less than 0.05): stanozolol (17 alpha-methyl-5 alpha- androstano [3,2-c]pyrazol-17 beta-ol), methanedienone (17 beta-hydroxy-17 alpha-methyl-1,4-androstadien-3-one), and fluoxymesterolone (9 alpha-fluoro-11 beta-hydroxy-17 alpha-methyl-T). Other compounds had RBAs too low to be determined (e.g. oxymetholone (17 beta-hydroxy-2-hydroxymethylene-17 alpha-methyl-5 alpha-androstan-3-one) and ethylestrenol (17 alpha-ethyl-4- estren -17 beta-ol). The competition pattern was similar in muscle and prostate, except for a higher RBA of DHT in the prostate. The low RBA of DHT in muscle was probably due to the previously reported rapid reduction of its 3-keto function to metabolites, which did not bind to the AR [5 alpha-androstane-3 alpha, 17 beta-diol and its 3 beta-isomer (3 alpha- and 3 beta-adiol, respectively)]. Some anabolic-androgenic steroids (only a few synthetic) bound to SHBG (1 alpha-methyl-DHT much greater than DHT greater than T greater than 3 beta-adiol greater than 3 alpha-adiol = 17 alpha-methyl-T greater than methenolone greater than methanedienone greater than stanozolol). The ratio of the RBA in rat muscle to that in the prostate (an estimate of the myotrophic potency of the compounds) was close to unity, varying only between about 0.4 and 1.7 in most cases.(ABSTRACT TRUNCATED AT 400 WORDS)

**Iron horse** · 04-19-2002, 11:32 AM

could you summerize a bit for challenged people like myself.

so, do steroids affect skelatal muscle?

**cnyce89** · 04-19-2002, 11:37 AM

I myself feel trhe same way....Some makes sence but most doesnt...a less scientific explanation would be nice if you got the time

**Dr.Evil** · 04-19-2002, 11:45 AM

in summary, proviron binds the strongest to SHBG followed by dht, and a few others with insignificant binding affinities.

for the androgen receptor in muscles, deca is stronger than primo and primo is stronger than testosterone , followed by proviron. the ones that don't bind to the AR are winny, dbol , halo, and abombs.

dht bound the strongest of all in the prostate, but not so much in the skeletal muscles.

**Dr.Evil** · 04-19-2002, 12:45 PM

anybody know what methyltrienolone is? this sucker seems to be pretty damn strong...

**cnyce89** · 04-19-2002, 01:08 PM

a synthetic androgen with high affinity for the receptor
a synthetic non- metabolizeable androgen

**Dr.Evil** · 04-19-2002, 01:13 PM

Originally posted by cnyce89
a synthetic androgen with high affinity for the receptor

i figure that, but is there a brand name that it's sold under?

**cnyce89** · 04-19-2002, 01:15 PM

oh trust me im searching, nothing yet though...Id love to know what this woud do for gains!
im determined to find this, ill hit you off with a PM if i can

**cnyce89** · 04-19-2002, 01:21 PM

It's called methyltrienolone , trade name Metribolone, ostensibly an oral form of trenbolone alkylated at the 17th carbon position that is almost impossible to displace from androgen receptor sites. He claims it is 50 times more androgenic than methytestosterone, yet also by far the most toxic steroid you could ever hope to find.

**Dr.Evil** · 04-25-2002, 12:08 PM

can anyone confirm if methyltrienolone aka metribolone is cheque drops ?

**jbrand** · 04-25-2002, 12:19 PM

Originally posted by Dr.Evil
can anyone confirm if methyltrienolone aka metribolone is cheque drops?

i really don't think so, cheque drops are mibolerone . it's very close though, it's a hybrid between mibolerone and trenbolone . as far as methyltrienolone , Ciba-Geigy never even brought it to the market.

**cnyce89** · 04-25-2002, 12:28 PM

Ahh someone else sheds some light on the subject

**Dr.Evil** · 04-25-2002, 12:32 PM

interesting. thanks

**Dr. Derek** · 04-25-2002, 12:55 PM

can we add a chemistry forum to this site.

**Iron horse** · 04-25-2002, 02:00 PM

keep this bumped, keep up posted about this drug that we don't no about!!

interesting as hell.

**Big Rush** · 04-25-2002, 02:12 PM

bump...

**jbrand** · 04-25-2002, 02:53 PM

this information is only good for trivia pretty much. all the information (even toxicity reports) was pretty much never disclosed by pharmaceutical companies. if it was in fact approved for medical use (i think it was researched for combatting some of the effects of breast cancer) i am sure it would be a big factor in the BBing world. it is said to be 1000x more potent than dbol .

**Dr.Evil** · 04-25-2002, 03:53 PM

yeah, proviron is good. when too much free shbg is present in the blood it binds to testosterone and prevents testosterone from "working." proviron can bind to the shbg and "free up" the testosterone, thus allowing it to "work."