SHBG synthesis

[oswaldosalcedo]

The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss.

Strain G, Zumoff B, Rosner W, Pi-Sunyer X.

Division of Endocrinology and Metabolism, Mount Sinai Medical Center, New York, New York 10029.

It is known that there is an inverse relationship between the serum levels of insulin and sex hormone-binding globulin (SHBG) in women, but the relationship in men has not been reported. It is not known whether changes in the one cause changes in the other, or whether they change in opposite directions in response to some third factor. Because obesity raises insulin levels and lowers SHBG levels in both sexes, we proposed to study the cause-effect question by determining whether the relationship between changes in SHBG and insulin levels during active weight loss. We studied 70 healthy weight-stable men with body mass index (BMI) from 20.7-94 (normal, 22.5 +/- 2.5) and restudied 17 of them during diet-induced weight loss. Fasting serum insulin levels in the weight-stable men showed a positive linear correlation with BMI, increasing 1 microU/mL per unit increase in BMI (P < 0.0001). SHBG levels in the weight-stable men showed a negative linear correlation with BMI, decreasing 0.2 nmol/L per unit increase in BMI (P < 0.0002). In the weight-stable men, there was an inverse hyperbolic correlation between SHBG and insulin levels; SHBG (nmol/L) = 13.1 + [30.1 divided by insulin (microU/mL)] (P < 0.002). During weight loss, insulin levels decreased at an average rate of 6.1 microU/mL per unit decrease in BMI, a much higher slope than the positive slope vs. BMI in weight stable men. During weight loss, SHBG levels increased at an average slope of 0.43 nmol/L per unit decrease in BMI, much higher than the negative slope of 0.2 nmol/L per unit increase in BMI in weight-stable men. Values for the SHBG vs. insulin coordinates in the weight-losing subjects did not differ significantly from those expected from the SHBG vs. insulin equation in weight-stable subjects. The stability of the SHBG-insulin relationship during weight loss despite the profoundly altered relationship of each separate component to BMI strongly suggests a close metabolic link between SHBG and insulin. As SHBG is not known to alter the production or metabolism of insulin, whereas insulin has been shown in vitro to decrease the synthesis of SHBG, it seems a reasonable conclusion that the predictable inverse relationship between serum insulin and SHBG indicates that insulin controls SHBG synthesis in vivo.

[Mesomorphyl]

Great find! Now with everyone talking shorter cycles maybe after adding the dht derived compounds and gains slow insulin is the key to making the best of longer cycles.

[Pinnacle]

Nice post Ossie!!

~Pinnacle~

[JohnnyB]

This needs to be in tha anabolic forum so more people can see it

JohnnyB

[stupidhippo]

excellent post...

[JohnnyB]

TTT

JohnnyB

[D.Rod 004]

Good to know!

[timvds]

In english???

[oswaldosalcedo]

Great find! Now with everyone talking shorter cycles maybe after adding the dht derived compounds and gains slow insulin is the key to making the best of longer cycles.

skyrocketing deduction !

[Pinnacle]

In english???

What is it you aren't understanding?

~Pinnacle~

[BajanBastard]

In english???

Sure.Insulin lowers SHBG levels, the less SHBG the more anabolics are able to do their job. On the other hand SHBG extends the active life of the drug so lowering it will cause the AAS to be metabolized and cleared faster.

Also some AAS don't bind to SHBG very well at all so in some cases lowering it may not be needed.

[stupidhippo]

Yeah there are many questions that remain unanswered... I dont believe we have found out the single right answer that causes long cycles to plateau.. but some promising theories have been thought of.

[oswaldosalcedo]

Yeah there are many questions that remain unanswered... I dont believe we have found out the single right answer that causes long cycles to plateau.. but some promising theories have been thought of.

read:
How long for receptors to clear?
How long for receptors to clear?

[stupidhippo]

Ive read it. excellent read..... that was mainly what I had in mind when I was writing my statement.. Lotsa great points...