Tamox or Novaldex?

[mtxz453]

Is there a big difference between these two? I've heard pretty good stuff about both and was just wondering which one was more effective.

[C_Bino]

They are on in the same my friend.
Its funny BD just asked me the same question...

[marcus300]

Its exactly the same thing,

[C_Bino]

Hey Marcus dont be so hard on the guy. I remember the PM you sent me last week asking me what the difference was between Clomid and Clomiphene.

[MrMent1on]

there are several arguments that nolvadex is actually better than clomid for pct. however IMO they are too close to be a significant difference.

[marcus300]

Hey Marcus dont be so hard on the guy. I remember the PM you sent me last week asking me what the difference was between Clomid and Clomiphene.

lol, i wasnt hard just stating a fact you gyno doctor !!!!

[farrebarre]

same thing different names,

[MrMent1on]

I am not sure how Nolvadex became so separated in the minds of bodybuilders. They certainly should not be. Clomid and estrogen receptor modulators (SERMs) with mixed agonistic and antagonistic properties. This means that in certain tissues they can block the effects of estrogens, activating the receptor. In men, both of these drugs act as anti-estrogens in their capacity to oppose the negative feedback of Clomid is the only drug good at stimulating testosterone . What you will find with a little investigation however is that not only is Nolvadex instead of Clomid daily for the same duration (the testosterone increase was slightly, but not significantly, better for Clomid. With the price of both a 50mg Nolvadex typically very similar, we are already seeing a cost vs. results discrepancy forming that strongly favors the Nolvadex and Nolvadex, pituitary sensitivity to GnRH increased slightly compared to pre-treated values. This is contrast to 10 days of treatment with 150mg " Nolvadex progresses to 6 weeks, pituitary sensitivity to GnRH was significantly higher than pre-treated or 10-day levels. At this point the same 20mg dosage was also raising testosterone and LH levels to an average of 183% and 172% of base values, respectively, which again is measurably higher than what was noted 10 days into therapy. Within 10 days of treatment Nolvadex serves only to increase pituitary sensitivity to this hormone. That is not to say Nolvadex.



The Clomid


The above discrepancies are likely explained by differences in the estrogenic nature of the two compounds. The researchers' clearly support this theory when commenting in their paper, "The difference in response might be attributable to the weak intrinsic estrogenic effect of " tamoxifen treatment". In reviewing other theories later in the paper, such as interference by increased androgen or Clomid which is practically absent in Clomid, which although a strong anti-estrogen at the hypothalamus, seems to exhibit weak estrogenic activity at the pituitary. To find further support for this we can look at an in-vitro animal study published in the American Journal of Physiology in February 1981 (2). This paper looks at the effects of Nolvadex on the GnRH stimulated release of LH from cultured rat pituitary cells. In this paper, it was noted that incubating cells with estrogen when both were incubated in the same culture.



Conclusion


To summarize the above research succinctly, Nolvadex is the more purely anti-estrogenic of the two drugs, at least where the HPTA (Hypothalamic-Pituitary-Testicular Axis) is concerned. This fact enables Clomid. This is especially true at times when we are looking to restore a balanced HPTA, and would not want to desensitize the pituitary to GnRH. This could perhaps slow recovery to some extent, as the pituitary would require higher amounts of hypothalamic GnRH in the presence of Nolvadex would seem to provide a better and more stable increase in testosterone levels , and likely will offer a similar or greater effect than " Clomid, supported by other research (3), is also cause for concern, as this might work to allow for comparably less free active testosterone compared to gyno and elevation of endogenous testosterone, however the above research provides enough evidence for me to choose Nolvadex would seem to provide a better and more stable increase in testosterone levels, and likely will offer a similar or greater effect than

[C_Bino]

Yo MrMent1on I didnt even pass grade 11 computer programming how can i read that...you always gotta shove it in my face that you can speak computer programming language and I cant...

[marcus300]

we are talking about nolva and tomax.....not clomid

[MrMent1on]

NOLVADEX (tamoxifen citrate) its is the same thing. tamoxifen is just the pharmaceutical name of nolvadex . he probably meant to compare clomid with nolvadex.

[crash187ct]

there are several arguments that nolvadex is actually better than clomid for pct. however IMO they are too close to be a significant difference.

clomid and nolvadex , aren't even in the same ballpark....