Saturating the AR

[Warrior]

Does anyone know of an equation to determine how much androgen it would take to saturate the AR (based on LBM, I guess)... where the cycle would then rely on non-AR mediated results? Or an equation that would base a recommended total weekly androgen use on an athlete's LBM...

Any personal experiences with receptor mapping and best guesses is kewl...



Or... any new studies or pubs with some more info on this type of thing?

[guest589745]

I wanna learn about this too.

Bump.

[FranKieC]

Bump for the marcenary mod

[shadyadam]

Have you seen this?

http://www.mesomorphosis.com/article...regulation.htm

[shadyadam]

And here is another.

Hope this helps fellas!

http://www.mesomorphosis.com/article...c-steroids.htm

[Swifto]

Have you seen this?

http://www.mesomorphosis.com/article...regulation.htm

Yes. Great article.

[FranKieC]

And here is another.

Hope this helps fellas!

http://www.mesomorphosis.com/article...c-steroids.htm

Nice read..

[shadyadam]

Hey I try...oh hey does this get me mod privileges for the day

[vitor]

I always have this in mind when I cycle.

For example when using a drug like Trenbolone(which has exstremely potent binding to the AR), There is little point in stacking it with an another aas that also has it actions on the AR-recepter IMO. (The only sensible exeption being testosterone.)

Stacking tren with deca, Eq or Primo would have little benefit as the AR would probaly be saturated from the Tren alone, unless a low dose was being used.

It would provide best synergi to use drugs that covers the AR+ the non AR-meditaded, to get anabolic reactions from two diffrent angels.

[Warrior]

And here is another.

Hope this helps fellas!

http://www.mesomorphosis.com/article...c-steroids.htm

Yeah, I was rereading this one actually:
http://www.mesomorphosis.com/article...c-steroids.htm

Which is what got me thinking about the original question... good articles by Bill...

[Warrior]

I always have this in mind when I cycle.

For example when using a drug like Trenbolone(which has exstremely potent binding to the AR), There is little point in stacking it with an another aas that also has it actions on the AR-recepter IMO. (The only sensible exeption being testosterone.)

Stacking tren with deca, Eq or Primo would have little benefit as the AR would probaly be saturated from the Tren alone, unless a low dose was being used.

It would provide best synergi to use drugs that covers the AR+ the non AR-meditaded, to get anabolic reactions from two diffrent angels.

Okay for this lets say testosterone only... at what point would testosterone fully saturate the AR, grab the other benefits and have little other risks or effects not related to greater performance/muscle gain...

I guess, there are probably too many variables to come up with a standard equation for everyone... (training intensity, diet, cortisol levels, individual biochemistry...)... but it would be interesting to see what people actually find is a standard, acceptable weekly steroid burden based on an individuals stats...

Like 12-15mg per 1kg of LBM... but like you said Vitor, some gear has known and unknown non-AR effects... so for arguement's sake - lets go with straight testosterone here... I guess...

[vitor]

Okay for this lets say testosterone only... at what point would testosterone fully saturate the AR, grab the other benefits and have little other risks or effects not related to greater performance/muscle gain...

I guess, there are probably too many variables to come up with a standard equation for everyone... (training intensity, diet, cortisol levels, individual biochemistry...)... but it would be interesting to see what people actually find is a standard, acceptable weekly steroid burden based on an individuals stats...

Like 12-15mg per 1kg of LBM... but like you said Vitor, some gear has known and unknown non-AR effects... so for arguement's sake - lets go with straight testosterone here... I guess...

Ive read alot of work from drug-guro "Bill Roberts" when it comes to recepter-binding, which drug-combination(stacks) that has proven to provide best gains, and which drugs which will be the most effective in stand alone cycles.

Trenbolone binds about 3-times stronger to the AR than Test does, so natrually, you would need atleast 3-times the test dosage to get the same effect. But not all muscle grow comes thrue the AR recepter. Test seems to be effective at the non-AR meditaded mechanism as well. Still per mg, Tren seems to be more effective than Test, especially for promoting strenght. (Probaly because of it high androgens.) Both Tren and test have muscle-growing effects, also unrelated to the AR and non-AR meditaded too.

Some steroids have slightly diffrent affects at the same recpter, though. Like for example D-bol and winstrol. They stimulate the non AR meditaded in diffrent ways, and can be satcked with nice "synergi". D-bol and Anadrol together would be pointless, though.

How much Testosterone one could take to fully saturate the AR-recepter, varies from person to person. As some people have more "open" recepters. However, if someone was to take for example 6 gram test per week. Its not certion that more drugs will promote more gains, as all recepters could be saturated by this exstreme dosage. I guess nobody can know for sure...

[guest589745]

You guys should keep discussing this.....

[Warrior]

Let's forget trenbolone or any other deriative with heavy binding affinity - just testosterone here (the clinical base for androgens anyway)... at what point would the supraphysiological amount of testosterone saturate the AR, cause some non-AR mediated results and still be "reasonable use" based on LBM?