Shooting Blanks? It May Be the Tamoxifen

[*Narkissos*]

Shooting Blanks? It May Be the Tamoxifen

by Bryan Haycock, MS, CSCS

Some call it cruelty to animals, some call it science, I call it Research Update! Our primate friends [not to be confused with our acr*****lic, GH abusing, homosapien friends] have stepped up to the plate to ensure new drugs are safe and ready for human consumption. Our hats go off to them in this months Research Update.

Title: Effect of chronic administration of Tamoxifen on fertility in male bonnet monkeys (Macaca radiata).

Researchers: Rao AJ, Ramachandra SG, Ramesh V, Krishnamurthy HN, Jayaraman S, Gopalakrishnan K, Juneja HS

Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India.

Source: Andrologia 1998 May-Jun;30(3):129-32

Summary: Administration of Tamoxifen via the Alzet pump at a rate of 50 micrograms hr-1 for 90 days in the adult male bonnet monkeys Macaca radiata had no effect on the serum testosterone concentration determined at 10 AM and 10 PM as well as total sperm count determined at 15-day intervals over a period of 260 days. However, a significant reduction in sperm motility was observed beyond 90 days up until the 225th day. Breeding studies conducted from day 90 to 260 revealed that these males were infertile.

Discussion: Tamoxifen, or Nolvadex , is classified as an antiestrogen. I’m sure most of you are already familiar with this drug. It works as an antiestrogen by competitively binding to estrogen receptors. Although it has high affinity for estrogen receptors it has little if any estrogenic effects in most tissues. It is used by bodybuilders to prevent or treat gynecomastia and water retention. The interesting thing about this study was the fact that Tamoxifen, an antiestrogen, made the male monkeys infertile. This is in agreement with another recent study looking at the effects of an aromatase inhibitor (Steroids 1998 Jul-Aug;63(7-:414-20) on fertility also in male monkeys. Both of these studies point to an important role of estrogen in male fertility. Tamoxifen, unlike the aromatase inhibitor which caused a 2-10 fold increase in serum testosterone levels , showed no effect on serum testosterone. The effect on spermatogenesis was clearly due to estrogen. Their sperm count was fairly normal, however, the sperm couldn’t swim to save their own lives. The take home message is that if you want to start a family between shows, stay away from Nolvadex and Proviron . On the other hand, these two compounds may be potential male birth control remedies. I guess the glass is either half full or half empty depending on how you look at it.

[taquipariu]

Well,

I did tamoxifen a long time ago, while I was on my last cycle.
And some time after too.

I realised I didn´t get any girl to get pregnant. HEHEHE
But seriously now, after I used it, my girlfriend didn´t get pregnant, even while she forgot to take the pill. Nowadays and some time ago I started thinking about it, because some people say it´s "lucky" to get pregnant, because of all the standards needed to get. I mean, like temperature, acidity, etc.
I don´t believe it, and I think I got sterile. HAHAHA
At least I will have none to pay 10% in my work paychecks.

Sorry If not understood. I am not a great english speaker/writer.

[LocoCabron]

geezzzzz. as i was just asking about this... i guess you choose between ending up with girlie boobs... or not being able to have kids...

i'm going to the sperm bank manana to have my swimmers stored for a future day while they're still working!

[zircon]

I wonder about that as well. I had blood test recently...everything was normal except fsh...follicle stimulating hormone, which I believe has to do with maturation of sperm?Mine was very low.

1.7 range: 1.2 - 15 and I did steroids /nolva short cycle about 4 months ago.

DOes anyone know the effect of FSH on test production etc? My lh seems normal = 5 range 1.3 - 9

???

[Pinum]

Was the nolva administered a particular high value. There is allot of debate on AAS causing infertility this does not sound like good news. the monkeys were infertile almost a year later. Thanks for the info people don't usually talk about the negatives.

[*Narkissos*]

bump!

[humungus88]

So, is this permanent? Or does it get back to norma after nolva is ended?

[humungus88]

In case anyone is interested.....

http://www.maleinfertilityhouston.com/infertility.shtml