Question Regarding Natty Test, DHT & Hairloss

[MoneyAddyct]

I'm not sure if this is the right forum for my question, but I can't imagine one more suitable. Here's what I was wondering based on what I already know. When you're in your 20s, you have the most testosterone (naturally) that you'll ever have circulating in your system. The conversion of testosterone to DHT accounts for (not all, but most) MPB and hairloss. So if one has the greatest amount of test in their system in their 20s, then how come the greatest amount of DHT isn't produced at that time and consequently hairloss is not a problem for people in their 20s? It would seem like someone who is in their 50s would experience less DHT conversion and consequently less hairloss because they have less test in their system than someone in their 20s.

Just a thought. Hopefully someone who knows a little bit more about biochemistry than I do might be able to answer this. I have no idea how test or DHT works, etc. Thanks.

MoneyAddyct

[CBHITMAN]

ok, actually, i was absent that day in school.

[MoneyAddyct]

me too apparently

[magic32]

I'm surprised Seattle didn't grab this one already.

The answer to your question is two fold, both hormonal and genetic:

Firstly, it is a long established fact that there is a correlation between MPB and DHT, which is why many of the treatments for MPB include decreasing the amount of DHT in the scalp that can affect the hair follicles. The rate-limiting factor in the production of DHT is primarily the amount of the enzyme 5 alpha reductase available to convert the testosterone to DHT. So, having more testosterone in the body does not necessarily mean there is also going to be more DHT.

Secondly, your DNA carries an encoded genetic blueprint. This determines when (manly) hormones are released, thereby signaling the onset of puberty for each individual...thus we get early bloomers (baritones in middle school, facial hair freshman year, etc.) and late bloomers. Similarly, this blueprint carries a 'time release' if you will, for the onset of MPB. Again we see it in 20's fresh out of college, in 30's, 40's, 50's and sometimes not at all.

M.

[Seattle Junk]

I'm surprised Seattle didn't grab this one already.

The answer to your question is two fold, both hormonal and genetic:

Firstly, it is a long established fact that there is a correlation between MPB and DHT, which is why many of the treatments for MPB include decreasing the amount of DHT in the scalp that can affect the hair follicles. The rate-limiting factor in the production of DHT is primarily the amount of the enzyme 5 alpha reductase available to convert the testosterone to DHT. So, having more testosterone in the body does not necessarily mean there is also going to be more DHT.

Secondly, your DNA carries an encoded genetic blueprint. This determines when (manly) hormones are released, thereby signaling the onset of puberty for each individual...thus we get early bloomers (baritones in middle school, facial hair freshman year, etc.) and late bloomers. Similarly, this blueprint carries a 'time release' if you will, for the onset of MPB. Again we see it in 20's fresh out of college, in 30's, 40's, 50's and sometimes not at all.

M.

Hehe, what magic said. Good post.

My theory on the 5-AR enzyme is that it increases with age as our body goes through the natural degeneration process. Ahhh, but we're kinda smart cause we realize test, GH, etc slows down or stops the degeneration process and possibly aging. Wow, did we stumble onto this forum or did we research our way here? Everybody is different though. I know of a guy way back in HS that was just about bald by the time he was a senior. I saw him a few years later and he just had hair on the sides and back of his head. I don't think anybody really knows the reason tied in with genetics why some lose hair faster than others? I've read that some people have more DHT receptors in the MPB zone than others. But then I almost question that theory based on the test to DHT conversion catalyst, the 5-AR enzyme. But all males have a certain amount of MPB eventually. This also includes some women as well based on genetics and hormone balance. Some women show MPB and some have overall thinning.

Of course I'm sure everbody in this thread knows that 5-AR inhibitors like finastride and dutastride retards or almost stops the conversion of test into DHT? Isn't modern science great?

[MoneyAddyct]

I was just about to ask that...whether, consequently, the 5-AR enzyme must increase with age if the preceeding information was true. That would make the most sense since hairloss can't be tied directly to test levels and dht conversion. Of course, genetics always plays a role. Interesting stuff. Thanks for the reply.

[Swifto]

Hehe, what magic said. Good post.

My theory on the 5-AR enzyme is that it increases with age as our body goes through the natural degeneration process. Ahhh, but we're kinda smart cause we realize test, GH, etc slows down or stops the degeneration process and possibly aging. Wow, did we stumble onto this forum or did we research our way here? Everybody is different though. I know of a guy way back in HS that was just about bald by the time he was a senior. I saw him a few years later and he just had hair on the sides and back of his head. I don't think anybody really knows the reason tied in with genetics why some lose hair faster than others? I've read that some people have more DHT receptors in the MPB zone than others. But then I almost question that theory based on the test to DHT conversion catalyst, the 5-AR enzyme. But all males have a certain amount of MPB eventually. This also includes some women as well based on genetics and hormone balance. Some women show MPB and some have overall thinning.

Of course I'm sure everbody in this thread knows that 5-AR inhibitors like finastride and dutastride retards or almost stops the conversion of test into DHT? Isn't modern science great?

I'm surprised Seattle didn't grab this one already.

The answer to your question is two fold, both hormonal and genetic:

Firstly, it is a long established fact that there is a correlation between MPB and DHT, which is why many of the treatments for MPB include decreasing the amount of DHT in the scalp that can affect the hair follicles. The rate-limiting factor in the production of DHT is primarily the amount of the enzyme 5 alpha reductase available to convert the testosterone to DHT. So, having more testosterone in the body does not necessarily mean there is also going to be more DHT.

Secondly, your DNA carries an encoded genetic blueprint. This determines when (manly) hormones are released, thereby signaling the onset of puberty for each individual...thus we get early bloomers (baritones in middle school, facial hair freshman year, etc.) and late bloomers. Similarly, this blueprint carries a 'time release' if you will, for the onset of MPB. Again we see it in 20's fresh out of college, in 30's, 40's, 50's and sometimes not at all.

M.

Excellent information.