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  1. #1
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    Thumbs up MUST READ!!! Secret of the PROS #177-191 :)

    THE HOTTEST NEW FAT BURNING PRODUCT TO HIT THE MARKET!!!




    Below is the secret of the pros my friends. (Secret #177-191 )



    This is the future of fat burning.





    hGH PROTEIN PEPTIDE FRAGMENT 177-191





    AnabolicReview-Research is very happy to bring to you one of the hottest new products from Research-Unlimited: The hGH protein peptide fragment 177-191. Researchers have isolated the fat burning properties of hGH by isolating the weight lose peptide located on the C-terminal region of the human Growth Hormone . It does not induce hyperglycemia, reduce insulin secretion, nor does it induce cell proliferation. Unlike hGH, however, hGH fragment does not interact with the hGH receptor. It does not induce hyperglycemia, reduce insulin secretion, nor does it induce cell proliferation.




    Result: a peptide that increases fat oxidation, triggers lipolytic sensitivity, and induces weight loss! Unlike hGH, however, hGH fragment does not interact with the hGH receptor.




    Effect:
    Pure fat loss!!





    "We are very excited to release this peptide to the public. Please take before and after pictures!!"


    LION




    Here is the link:

    hGH Protein Peptide Fragment 177-191
    Last edited by RUI-Products; 12-21-2006 at 02:31 PM.

  2. #2
    RA's Avatar
    RA
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    Sounds good. Ill have to give that one a try.

  3. #3
    SukaDaddio is offline Junior Member
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    This is very cool to hear.. i need to look into this..

  4. #4
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    Quote Originally Posted by Lion
    THE HOTTEST NEW FAT BURNING PRODUCT TO HIT THE MARKET!!!




    Below is the secret of the pros my friends. (Secret #177-191 )



    This is the future of fat burning.





    hGH PROTEIN PEPTIDE FRAGMENT 177-191





    AnabolicReview-Research.com is very happy to bring to you one of the hottest new products from Research-Unlimited: The hGH protein peptide fragment 177-191. Researchers have isolated the fat burning properties of hGH by isolating the weight lose peptide located on the C-terminal region of the human Growth Hormone .




    Result: a peptide that increases fat oxidation, triggers lipolytic sensitivity, and induces weight loss! Unlike hGH, however, hGH fragment does not interact with the hGH receptor. It does not induce hyperglycemia, reduce insulin secretion, nor does it induce cell proliferation.




    Effect:
    Pure fat loss!!





    "We are very excited to release this peptide to the public. Please take before and after pictures!!"


    LION




    Here is the link:

    hGH Protein Peptide Fragment 177-191

    Sweet! Whats the dosing on this?????

  5. #5
    PROTEINSHAKE's Avatar
    PROTEINSHAKE is offline Protein Power
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    can someone explain how to use this???? dosages, duration etc.

  6. #6
    dblock189 is offline Associate Member
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    Yea lion can you please explain? when you mean fat burning what would you say the limit on bodyfat should be? how does it work exactly? dosage? duration ? all the good stuff. Can you please elaborate? Im interested

    dblock

  7. #7
    goalseeker's Avatar
    goalseeker is offline Anabolic Member
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    has anyone tested it yet? does it actually really work?

  8. #8
    graeme87 is offline Member
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    bump

  9. #9
    skipp is offline Senior Member
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    bump 2

  10. #10
    dblock189 is offline Associate Member
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    bump

  11. #11
    trulbfan3 is offline Member
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    who knows, but i had no luck with lions liquid clen and t3 so i dont think ill be trying this one till some ppl test it out.

  12. #12
    skipp is offline Senior Member
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    if clen and t3 didnt help u, look towards your diet.

    (non intentional bump)

  13. #13
    Snrf's Avatar
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    lion give like 5 people on the board free samples and have them do a trial. ill do it and make sure i get b4 and after pics. i'm def interested as are many others obviously but $50 on something completely untried is alot.

  14. #14
    skipp is offline Senior Member
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    Quote Originally Posted by Snrfmaster
    lion give like 5 people on the board free samples and have them do a trial. ill do it and make sure i get b4 and after pics. i'm def interested as are many others obviously but $50 on something completely untried is alot.
    That's a good idea, if I saw some neutral opinions or a study (which I doubt there is either since it's new) I'd be more than willing...

  15. #15
    snoopy's Avatar
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    Quote Originally Posted by Snrfmaster
    lion give like 5 people on the board free samples and have them do a trial. ill do it and make sure i get b4 and after pics. i'm def interested as are many others obviously but $50 on something completely untried is alot.
    I agree, how do we know it works, I dont think anyone will buy it unless we know someone personally who has benefited from this. This is the first i have heard about it and I am in contact with some guys who have won major comps. None of them have heard if this, but all are raving about the benefits of IGF and HGH together. This is one we need to experience to believe...sorry lion..

  16. #16
    Altaballer38 is offline New Member
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    Yeah lion whats the dosage? I read on my home board that the dosing is 200 mcg's/day.

  17. #17
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    pit_bully is offline Associate Member
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    Has anyone ever heard of this before? Im not doubting just curious.

  18. #18
    elite2kr is offline Member
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    inovative research has had this product for along time now.....

  19. #19
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    Wow looks interesting. Dosage?

  20. #20
    kobiack's Avatar
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    this stuff sounds amazing! i'm def going to try it. how long has it been around?

  21. #21
    *Admin* is offline AR Admin
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    Interesting...
    Every man has the ability to be a fool, it is what he does to recover that shows who the fool really is.
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    ~Aldous Huxley~


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  22. #22
    C_Bino's Avatar
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    So Lion, since this is a fragment of the HGH chain. Would it have the identical effect that running GH at the same dosage would have for fat loss? Or by extracting it are we somehow enhancing the fat loss capabilities. This is interesting.

  23. #23
    IBdmfkr's Avatar
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    Or you could cut your calories back a bit and save money on not only your food bill but your drug bill as well Problem solved.

  24. #24
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    Yes it has the same effects on fat that Gh does. It doesn't cause the hypo effects Gh or insulin do. It doesn't compete with GH or IGF for the same receptor sites. I have to be honest I think this product will be great. We have a diabetic testing it and he has seen effects in 2 days. I have not started my research yet but will tomarro. As you know I can't comment on others research .....I will be starting mine at 200 mcg......ed

  25. #25
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    Here is a piece of a study about the fragment. The entire study can be found at http://endo.endojournals.org/cgi/co...ull/142/12/5182




    It is well established that hGH is a lipolytic hormone (15), but the exact mechanisms used are still unclear. In this paper we present data that suggest that hGH and its lipolytic fragment (AOD9604) induce their chronic in vivo actions on lipolysis in part by modulating the expression of the ß3-AR. Human GH has been shown to affect the in vivo expression and function of ß-ARs in vivo in sheep (16). Data presented in this paper indicate that chronic administration of hGH influences expression of the ß3-AR in adipose tissue in the ob/ob mouse. In brown adipose tissue (BAT), these compounds also increase expression of ß3-AR expression in the lean C57BL/6J mouse. The increase in expression induced by chronic hGH or AOD9604 treatment correlated with the decrease in adipose tissue mass. We therefore hypothesize that treatment with either hGH or AOD9604 enhances ß3-AR expression, which has been observed in murine 3T3-F442A and human SK-N-MC cells in vitro (11).

    Both AOD9604 and, to a greater extent, hGH increase body weight in lean mice, compared with saline-treated animals. This is in the absence of an increase in fat mass, which suggests an increase in lean body mass occurs with these compounds. This supports previous work with hGH in rodents and humans (17). Both compounds have also been previously shown to reduce body weight and adiposity in obese mice (11). The effects of hGH and AOD9604 occur without significant changes to caloric intake. It has been reported that hGH increases, reduces, or does not change food intake in which the differences are attributed to variations in hGH preparations, concentrations, and animals used between different laboratories.

    The effects of hGH and AOD9604 on fat metabolism may be mediated by an alteration in the expression of a lipolytic/antilipogenic gene. The &#223;3-AR is a major lipolytic receptor identified in rodent fat cells (18) that mediates its effects through G protein coupling to adenylate cyclase, generation of cAMP, and stimulation of PKA (19). This enzyme then phosphorylates proteins in the lipolytic cascade, including hormone-sensitive lipase (20). In BAT, the &#223;3-AR stimulates uncoupling of the electron transport chain, enhancing the ability of mitochondria to generate heat in preference to ATP through the dissipation of the electron gradient (21). Mice that lack this receptor have lower rates of resting energy expenditure (0.0041 vs. 0.0047 kcal/min, P < 0.02) and lower rates of fat oxidation (0.00019 vs. 0.00030 g/min, P < 0.02) than control mice (data not shown).

    AOD9604 and hGH appear to act in a similar manner to induce their effects on body weight regulation and adipose tissue mass in vivo. However, in vitro studies have demonstrated a number of differences suggesting that the two compounds operate via unique signaling pathways to control the regulation of the &#223;3-AR. These studies suggested that AOD9604 had no interaction with the &#223;3-AR or hGH receptors (11).

    In lean animals, neither AOD9604 nor hGH had any effect on epididymal white adipose tissue mass or expression of &#223;3-AR RNA, indicating that in lean animals, this fat tissue is not a major target for these drugs in this study. In contrast, the mass of BAT in lean animals was reduced by both hGH and AOD9604, and &#223;3-AR RNA expression was increased by both these compounds. This could possibly suggest that the increased expression of &#223;3-ARs in brown adipocytes sensitizes catecholamines to dissipate heat.

    In ob/ob mice, both AOD9604 and hGH reduced both white and brown adipose tissue mass and increased &#223;3-AR RNA expression. This suggested that an elevation in &#223;3-AR RNA expression is associated with increased fat metabolism and a reduction in the fat tissue mass in the ob/ob mouse model. Obese mice have lower levels of &#223;3-AR expression in their adipose tissues than lean mice, shown in this study and others (14). The ability of AOD9604 and hGH to increase the level of &#223;3-AR RNA expression in obese mice to a level that is comparable to those in lean mice is an exciting finding. However, it must also be considered that both hGH and AOD9604 may influence the expression of other members of the adrenergic pathway, such as the &#223;1-ARs, hormonesensitive lipase, and signaling proteins, which are all expressed in adipose tissue and associated with lipolysis. The importance of the change in &#223;3-AR expression with AOD9604 and hGH in humans is not established and will depend on the use of potent and selective &#223;3-AR agonists that are active at the human receptor.

    From this study it appears that the &#223;3-AR is an important contributor to the effects observed on body weight in obese mice treated with AOD9604 and hGH. To determine whether the &#223;3-AR is partly responsible for this effect, we examined the effects of AOD9604 and hGH in the &#223;3-KO mouse. The &#223;3-KO mouse is not grossly obese, but female mice have increased fat depots (21) and the mice do develop late-onset obesity (Summers, R. J., personal communication). AOD9604 and hGH increased body mass and decreased BAT mass in the WT strain but had no effect in the KO animals. In WT mice, plasma glycerol was increased in response to AOD9604 and hGH treatment (4 wk). However, in the KO mice, only hGH resulted in increased levels of glycerol in the KO mice, and this effect was significantly less than that observed in the WT mice. This suggests that the regulation of the &#223;3-AR is essential in the ability of AOD9604 and hGH to mediate chronic effects on lipolysis and fat mass reduction.

    The effect of AOD9604 and hGH on &#223;3-ARs in adipose tissue is believed to be a direct action of these compounds and not an effect secondary to the fat metabolism, given that both AOD9604 and hGH can influence &#223;3-AR expression and function in a nonadipocyte human cell line (11). Hence, the &#223;3-AR appears to be necessary for the chronic effectiveness of AOD9604 on lipolysis in BAT.

    The acute effect of AOD9604 and BRL37344 (a &#223;3-AR agonist) on energy expenditure and substrate oxidation rates in WT and KO mice was also assessed. KO animals had lower energy expenditure, lower fat oxidation, and increased glucose oxidation, compared with the WT controls (data not shown). Injection of WT mice with a single dose of BRL37344 or AOD9604 increased energy expenditure and fat oxidation and decreased glucose oxidation. In the KO animals, BRL37344 failed to elicit any response in these metabolic parameters, clearly demonstrating that its effects are mediated exclusively through the &#223;3-AR. AOD9604 did elicit a response in the KO mice, increasing fat oxidation and energy expenditure, although the response was not as great as in WT mice, suggesting that &#223;3-ARs are not responsible for the acute biological response of AOD9604 on lipid metabolism. This is consistent with our previous findings in which AOD9604 was shown not to bind to the &#223;3-AR (11). The size and duration of the metabolic responses to AOD9604 in the &#223;3-AR KO animals was different from that observed in the control wild-type mice. The response was more rapid, shorter in duration, and greater in peak response. This may be because the KO animals are more acutely sensitive to lipolytic agents, a compensation for the ablation of the major lipolytic receptor.

    These findings suggest that the acute effects of AOD9604 are quite different from the chronic effects. Enhanced &#223;3-AR expression appears to play a major role in the chronic effectiveness of the compound in terms of fat metabolism and weight loss. The acute effects observed in this study confirm that the &#223;3-AR is not the sole mediator of this action. The increase in &#223;3-AR expression in response to hGH and AOD9604 would permit enhanced lipolytic sensitivity. Identification of the components of the intracellular pathway(s) and effector(s) activated by AOD9604 are currently being investigated. The results presented in this paper suggest that the effectiveness of AOD9604 and hGH may partly rely on their ability to increase levels of &#223;3-AR RNA expression in models of obesity in which the numbers of the lipolytic receptor are low. These unique properties may give AOD9604 an advantage over other lipolytic agonists such as adrenergic agents and hGH, which exhibit undesirable side effects when administered chronically (22).
    __________________

  26. #26
    sheltonn is offline Junior Member
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    Come on, give out some free samples. My wife would love to try this. We don't mind taking pictures. Nudies if it REALLY works!

  27. #27
    1buffsob's Avatar
    1buffsob is offline Mr.Modesty
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    You're whoring your wife out for free samples. LMFAO!!

  28. #28
    sheltonn is offline Junior Member
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    They are for her. The HGH is working for me.

  29. #29
    kalla's Avatar
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    id love to try it

  30. #30
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    Quote Originally Posted by I**mfkr
    Or you could cut your calories back a bit and save money on not only your food bill but your drug bill as well Problem solved.

    I meannn you could I meann i meann you couldd!!!

  31. #31
    Panzerfaust's Avatar
    Panzerfaust is offline Ron Paul Nuthugger
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    Interesting..but i would never take this without reading reviews etc.
    ***No source checks!!!***

  32. #32
    hardgainer12's Avatar
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    whats the dosage per mg? its only 2mgs

  33. #33
    lifter76 is offline New Member
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    So how long should a person run this stuff. Is the dose 200mcg ed for 4 weeks??

  34. #34
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    top side

  35. #35
    BG's Avatar
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    BG is offline The Real Deal - AR-Platinum Elite- Hall of Famer
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    Quote Originally Posted by I**mfkr
    Or you could cut your calories back a bit and save money on not only your food bill but your drug bill as well Problem solved.
    We have a winner.

  36. #36
    cj1capp's Avatar
    cj1capp is offline Anabolic Member
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    Quote Originally Posted by Snrfmaster
    lion give like 5 people on the board free samples and have them do a trial. ill do it and make sure i get b4 and after pics. i'm def interested as are many others obviously but $50 on something completely untried is alot.
    great ideal i will step up and offer to be one of the five.!!!!

  37. #37
    cj1capp's Avatar
    cj1capp is offline Anabolic Member
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    Quote Originally Posted by Lion
    Here is a piece of a study about the fragment. The entire study can be found at http://endo.endojournals.org/cgi/co...ull/142/12/5182




    It is well established that hGH is a lipolytic hormone (15), but the exact mechanisms used are still unclear. In this paper we present data that suggest that hGH and its lipolytic fragment (AOD9604) induce their chronic in vivo actions on lipolysis in part by modulating the expression of the ß3-AR. Human GH has been shown to affect the in vivo expression and function of ß-ARs in vivo in sheep (16). Data presented in this paper indicate that chronic administration of hGH influences expression of the ß3-AR in adipose tissue in the ob/ob mouse. In brown adipose tissue (BAT), these compounds also increase expression of ß3-AR expression in the lean C57BL/6J mouse. The increase in expression induced by chronic hGH or AOD9604 treatment correlated with the decrease in adipose tissue mass. We therefore hypothesize that treatment with either hGH or AOD9604 enhances ß3-AR expression, which has been observed in murine 3T3-F442A and human SK-N-MC cells in vitro (11).

    Both AOD9604 and, to a greater extent, hGH increase body weight in lean mice, compared with saline-treated animals. This is in the absence of an increase in fat mass, which suggests an increase in lean body mass occurs with these compounds. This supports previous work with hGH in rodents and humans (17). Both compounds have also been previously shown to reduce body weight and adiposity in obese mice (11). The effects of hGH and AOD9604 occur without significant changes to caloric intake. It has been reported that hGH increases, reduces, or does not change food intake in which the differences are attributed to variations in hGH preparations, concentrations, and animals used between different laboratories.

    The effects of hGH and AOD9604 on fat metabolism may be mediated by an alteration in the expression of a lipolytic/antilipogenic gene. The ß3-AR is a major lipolytic receptor identified in rodent fat cells (18) that mediates its effects through G protein coupling to adenylate cyclase, generation of cAMP, and stimulation of PKA (19). This enzyme then phosphorylates proteins in the lipolytic cascade, including hormone-sensitive lipase (20). In BAT, the ß3-AR stimulates uncoupling of the electron transport chain, enhancing the ability of mitochondria to generate heat in preference to ATP through the dissipation of the electron gradient (21). Mice that lack this receptor have lower rates of resting energy expenditure (0.0041 vs. 0.0047 kcal/min, P < 0.02) and lower rates of fat oxidation (0.00019 vs. 0.00030 g/min, P < 0.02) than control mice (data not shown).

    AOD9604 and hGH appear to act in a similar manner to induce their effects on body weight regulation and adipose tissue mass in vivo. However, in vitro studies have demonstrated a number of differences suggesting that the two compounds operate via unique signaling pathways to control the regulation of the ß3-AR. These studies suggested that AOD9604 had no interaction with the ß3-AR or hGH receptors (11).

    In lean animals, neither AOD9604 nor hGH had any effect on epididymal white adipose tissue mass or expression of ß3-AR RNA, indicating that in lean animals, this fat tissue is not a major target for these drugs in this study. In contrast, the mass of BAT in lean animals was reduced by both hGH and AOD9604, and ß3-AR RNA expression was increased by both these compounds. This could possibly suggest that the increased expression of ß3-ARs in brown adipocytes sensitizes catecholamines to dissipate heat.

    In ob/ob mice, both AOD9604 and hGH reduced both white and brown adipose tissue mass and increased ß3-AR RNA expression. This suggested that an elevation in ß3-AR RNA expression is associated with increased fat metabolism and a reduction in the fat tissue mass in the ob/ob mouse model. Obese mice have lower levels of ß3-AR expression in their adipose tissues than lean mice, shown in this study and others (14). The ability of AOD9604 and hGH to increase the level of ß3-AR RNA expression in obese mice to a level that is comparable to those in lean mice is an exciting finding. However, it must also be considered that both hGH and AOD9604 may influence the expression of other members of the adrenergic pathway, such as the ß1-ARs, hormonesensitive lipase, and signaling proteins, which are all expressed in adipose tissue and associated with lipolysis. The importance of the change in ß3-AR expression with AOD9604 and hGH in humans is not established and will depend on the use of potent and selective ß3-AR agonists that are active at the human receptor.

    From this study it appears that the ß3-AR is an important contributor to the effects observed on body weight in obese mice treated with AOD9604 and hGH. To determine whether the ß3-AR is partly responsible for this effect, we examined the effects of AOD9604 and hGH in the ß3-KO mouse. The ß3-KO mouse is not grossly obese, but female mice have increased fat depots (21) and the mice do develop late-onset obesity (Summers, R. J., personal communication). AOD9604 and hGH increased body mass and decreased BAT mass in the WT strain but had no effect in the KO animals. In WT mice, plasma glycerol was increased in response to AOD9604 and hGH treatment (4 wk). However, in the KO mice, only hGH resulted in increased levels of glycerol in the KO mice, and this effect was significantly less than that observed in the WT mice. This suggests that the regulation of the ß3-AR is essential in the ability of AOD9604 and hGH to mediate chronic effects on lipolysis and fat mass reduction.

    The effect of AOD9604 and hGH on ß3-ARs in adipose tissue is believed to be a direct action of these compounds and not an effect secondary to the fat metabolism, given that both AOD9604 and hGH can influence ß3-AR expression and function in a nonadipocyte human cell line (11). Hence, the ß3-AR appears to be necessary for the chronic effectiveness of AOD9604 on lipolysis in BAT.

    The acute effect of AOD9604 and BRL37344 (a ß3-AR agonist) on energy expenditure and substrate oxidation rates in WT and KO mice was also assessed. KO animals had lower energy expenditure, lower fat oxidation, and increased glucose oxidation, compared with the WT controls (data not shown). Injection of WT mice with a single dose of BRL37344 or AOD9604 increased energy expenditure and fat oxidation and decreased glucose oxidation. In the KO animals, BRL37344 failed to elicit any response in these metabolic parameters, clearly demonstrating that its effects are mediated exclusively through the ß3-AR. AOD9604 did elicit a response in the KO mice, increasing fat oxidation and energy expenditure, although the response was not as great as in WT mice, suggesting that ß3-ARs are not responsible for the acute biological response of AOD9604 on lipid metabolism. This is consistent with our previous findings in which AOD9604 was shown not to bind to the ß3-AR (11). The size and duration of the metabolic responses to AOD9604 in the ß3-AR KO animals was different from that observed in the control wild-type mice. The response was more rapid, shorter in duration, and greater in peak response. This may be because the KO animals are more acutely sensitive to lipolytic agents, a compensation for the ablation of the major lipolytic receptor.

    These findings suggest that the acute effects of AOD9604 are quite different from the chronic effects. Enhanced ß3-AR expression appears to play a major role in the chronic effectiveness of the compound in terms of fat metabolism and weight loss. The acute effects observed in this study confirm that the ß3-AR is not the sole mediator of this action. The increase in ß3-AR expression in response to hGH and AOD9604 would permit enhanced lipolytic sensitivity. Identification of the components of the intracellular pathway(s) and effector(s) activated by AOD9604 are currently being investigated. The results presented in this paper suggest that the effectiveness of AOD9604 and hGH may partly rely on their ability to increase levels of ß3-AR RNA expression in models of obesity in which the numbers of the lipolytic receptor are low. These unique properties may give AOD9604 an advantage over other lipolytic agonists such as adrenergic agents and hGH, which exhibit undesirable side effects when administered chronically (22).
    __________________
    the link wont work but my offer still stands

  38. #38
    fossilfuel7's Avatar
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    Can anyone tell me if this product would also have the same benefits of tendon and ligament strength/healing?? as I have been leary to start GH for my tendonosis issues because of the insulin resistance/possible HYPO issues.

    ??

  39. #39
    layinglow is offline Junior Member
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    I took inovative research's hgh fragment about 6 months ago, like elite said it's been out for a while. I took it for 8 wks at 150 mcg's a day, and saw nothing. now if you take it at the suggested 200 mcg's a day, one bottle will only last 10 days. but I doubt the extra 50 mcg's a day would of made a difference.

  40. #40
    1819's Avatar
    1819 is offline Senior Member
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    free samples? man i see alot of threads lately on fat burning. clen vs. dnp , eca when not on clen, clen at high dose for months at a time, blah, blah, blah. a little less time reading and posting and a little more time on the treadmills people. these compounds are to help people over the hump once you have everything in check. they are not quick fixes!....p.s. lion's products are fantastic but dont just start gobbling this stuff up hoping its gonna change your life. nothing wrong with sweatin a little. peace.....

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