myth or fact

**doctadank** · 10-11-2006, 12:23 AM

does igf really clear your androgen receptors, so therefore requiring less time inbetween cycles(inclding pct but thats not what im talking about). Thanks

**doctadank** · 10-11-2006, 11:28 AM

Ttt^^^^^^^

**Surfstud18** · 10-11-2006, 11:34 AM

check out this thread

Putting it all together - HGH + IGF-1 + Slin – by RedBaron

it'll answer all your qs

cheers

***perfectbeast2001*** · 10-11-2006, 11:42 AM

Originally Posted by Surfstud18

check out this thread

Putting it all together - HGH + IGF-1 + Slin – by RedBaron

it'll answer all your qs

cheers

I didn't read anything in that thread that answered his question. Bump.

**Surfstud18** · 10-11-2006, 12:09 PM

Guess i suck then haha try this one http://*************.com/forum/stero...-androgen.html

**Surfstud18** · 10-11-2006, 12:11 PM

nevermind that one either this is tuff info to find

**doctadank** · 10-11-2006, 02:03 PM

why in gods name you sent me a sticky link is beyond me. you shouldnt judge someone by their post count.

**Surfstud18** · 10-11-2006, 04:49 PM

I sent you a sticky link hoping you would find what you were looking for bro not based on your post count so chill

**doctadank** · 10-11-2006, 05:10 PM

Originally Posted by Surfstud18

I sent you a sticky link hoping you would find what you were looking for bro not based on your post count so chill

yeh but you sent me a random ass link, that didnt have any information that i didnt arleady know, i just dont know what the point of your post was?

**Surfstud18** · 10-11-2006, 05:44 PM

Thought it would just have some info that you were looking for because i didn't have the answer so i tried researching it for you hoping i found one with some info you needed. Next time i'll just keep to myself sorry bro

**IBdmfkr** · 10-11-2006, 05:52 PM

I don't believe it clears your androgen receptors, as I don't believe they need to be "cleared".. it's more about your body's natural production returning to normal.. drugs such as Clomid/nolvadex /letrozole (femara) are required. HCG is also known to help revive LH function.

**1-Cent** · 10-11-2006, 05:59 PM

Myth: Androgen receptors need to be cleared.

**doctadank** · 10-13-2006, 01:46 PM

so why is there a decrease in effectiveness of steroids when used back to back? is it SHBG? or why do some steroids lose effectiveness after youve been on them for 8 weeks (without having to up the dosages/change compounds)

**juicejunkie2** · 10-13-2006, 02:05 PM

Like with many drugs ... when one uses a substance the # of receptors decreases .. called "down regulation" ... a way your body tries to stay in homeostasis. Once the # of receptors drops the compounds acting on the receptors produce less of the desired effect... a type of tolorence. Once you stop taking the drug the body regenerates the # of receptors to again maintain homeostasis. Hope that answers your question.

**fLgAtOr** · 10-13-2006, 02:11 PM

Originally Posted by juicejunkie2

Like with many drugs ... when one uses a substance the # of receptors decreases .. called "down regulation" ... a way your body tries to stay in homeostasis. Once the # of receptors drops the compounds acting on the receptors produce less of the desired effect... a type of tolorence. Once you stop taking the drug the body regenerates the # of receptors to again maintain homeostasis. Hope that answers your question.

That would be all gravy, but juice increases the amount of ARs.

**juicejunkie2** · 10-13-2006, 02:16 PM

Originally Posted by fLgAtOr

That would be all gravy, but juice increases the amount of ARs.

To a degree that's true but over time the # of receptors drop thus the tolorence. AAS act at the nuclear level .. meaning they have receptors that are activated to act on the cellular nucleus to make more receptors/proteins.... once the # of receptors AAS acts on is decreased then the effectiveness of making more receptors/proteins also decreases.

**doctadank** · 10-13-2006, 02:29 PM

so then how long would you say you need inbetween starting a new cycle and a cycle that you just previosuly ended that lasted 12 weeks. I know the general rule for time on=time off, but lets get serious here not many people follow that, especially ones that compete(not including people that cruise).

**stupidhippo** · 10-13-2006, 03:48 PM

Originally Posted by juicejunkie2

Like with many drugs ... when one uses a substance the # of receptors decreases .. called "down regulation" ... a way your body tries to stay in homeostasis. Once the # of receptors drops the compounds acting on the receptors produce less of the desired effect... a type of tolorence. Once you stop taking the drug the body regenerates the # of receptors to again maintain homeostasis. Hope that answers your question.

its just one mechanism.. androgen receptors are shown to upregulate when on cycle - but even up regulation can lead to tolerance.. these are complex things with a lot that we still dont know..

**DrugsrGood** · 10-13-2006, 04:04 PM

i would attribute this to shbg more than anything imo. like some of the others said, most info i have come across points to increased number of androgen receptors with increase of binding hormones... which leads me to believe shbg is the culprit.