myth or fact

[doctadank]

does igf really clear your androgen receptors, so therefore requiring less time inbetween cycles(inclding pct but thats not what im talking about). Thanks

[doctadank]

Ttt^^^^^^^

[Surfstud18]

check out this thread

http://forums.steroid.com/showthread.php?t=263288

it'll answer all your qs

cheers

[perfectbeast2001]

check out this thread

http://forums.steroid.com/showthread.php?t=263288

it'll answer all your qs

cheers

I didn't read anything in that thread that answered his question. Bump.

[Surfstud18]

Guess i suck then haha try this one http://*************.com/forum/stero...-androgen.html

[Surfstud18]

nevermind that one either this is tuff info to find

[doctadank]

why in gods name you sent me a sticky link is beyond me. you shouldnt judge someone by their post count.

[Surfstud18]

I sent you a sticky link hoping you would find what you were looking for bro not based on your post count so chill

[doctadank]

I sent you a sticky link hoping you would find what you were looking for bro not based on your post count so chill

yeh but you sent me a random ass link, that didnt have any information that i didnt arleady know, i just dont know what the point of your post was?

[Surfstud18]

Thought it would just have some info that you were looking for because i didn't have the answer so i tried researching it for you hoping i found one with some info you needed. Next time i'll just keep to myself sorry bro

[IBdmfkr]

I don't believe it clears your androgen receptors, as I don't believe they need to be "cleared".. it's more about your body's natural production returning to normal.. drugs such as Clomid/nolvadex/letrozole(femara) are required. HCG is also known to help revive LH function.

[1-Cent]

Myth: Androgen receptors need to be cleared.

[doctadank]

so why is there a decrease in effectiveness of steroids when used back to back? is it SHBG? or why do some steroids lose effectiveness after youve been on them for 8 weeks (without having to up the dosages/change compounds)

[juicejunkie2]

Like with many drugs ... when one uses a substance the # of receptors decreases .. called "down regulation" ... a way your body tries to stay in homeostasis. Once the # of receptors drops the compounds acting on the receptors produce less of the desired effect... a type of tolorence. Once you stop taking the drug the body regenerates the # of receptors to again maintain homeostasis. Hope that answers your question.

[fLgAtOr]

Like with many drugs ... when one uses a substance the # of receptors decreases .. called "down regulation" ... a way your body tries to stay in homeostasis. Once the # of receptors drops the compounds acting on the receptors produce less of the desired effect... a type of tolorence. Once you stop taking the drug the body regenerates the # of receptors to again maintain homeostasis. Hope that answers your question.

That would be all gravy, but juice increases the amount of ARs.

[juicejunkie2]

That would be all gravy, but juice increases the amount of ARs.

To a degree that's true but over time the # of receptors drop thus the tolorence. AAS act at the nuclear level .. meaning they have receptors that are activated to act on the cellular nucleus to make more receptors/proteins.... once the # of receptors AAS acts on is decreased then the effectiveness of making more receptors/proteins also decreases.

[doctadank]

so then how long would you say you need inbetween starting a new cycle and a cycle that you just previosuly ended that lasted 12 weeks. I know the general rule for time on=time off, but lets get serious here not many people follow that, especially ones that compete(not including people that cruise).

[stupidhippo]

Like with many drugs ... when one uses a substance the # of receptors decreases .. called "down regulation" ... a way your body tries to stay in homeostasis. Once the # of receptors drops the compounds acting on the receptors produce less of the desired effect... a type of tolorence. Once you stop taking the drug the body regenerates the # of receptors to again maintain homeostasis. Hope that answers your question.

its just one mechanism.. androgen receptors are shown to upregulate when on cycle - but even up regulation can lead to tolerance.. these are complex things with a lot that we still dont know..

[DrugsrGood]

i would attribute this to shbg more than anything imo. like some of the others said, most info i have come across points to increased number of androgen receptors with increase of binding hormones... which leads me to believe shbg is the culprit.

[stupidhippo]

even that doesnt explain the tolerance thing.. there was a real good thread about that whole topic some time ago...

[doctadank]

http://forums.steroid.com/showthread.php?t=209272