Tren Cough: Why?

[Stackertoo]

I know this is a side of Tren use for most. I was wondering why this particular compound causes this while others do not.
Anyone have even a semi-scientific explanation for this?

[goose]

It`s conected with Prostaglandins. They are made by two different pathways(Cyclooxygenase and Lipoxygenase), and considering prostaglandins are a group of about 20 lipid cells, they have contrary function; responsible for stimulating as well as alleviating inflammation(Inflammation stimulation is the rapid metabolism of them expelled through the bronchials), regulate blood flow to particular organs, control ion transport across membranes, modulate synaptic transmission, induce sleep, mediate lipid release, and regulate metabolism is various tissue.

Prostaglandins are synthesized from arachidonate(Lipoxygenase which catalyze the dioxygenation of polyunsaturated fatty acids) in the cell membrane by the action of phospholipase A2. Cyclooxygenase and lipoxygenase pathways, compete with one another to form prostaglandins(as well as thromboxane or leukotriene-leukotriene being a bronchial stimulator),
In the cyclooxygenase pathway, the prostaglandins D, E and F plus thromboxane and prostacyclin are made. Thromboxanes are made in platelets and cause constriction of vascular smooth muscle and platelet aggregation
Leukotrienes are made in leukocytes and macrophages via the lipoxygenase pathway. They are potent constrictors of the bronchial airways. They are also important in inflammation and hypersensitivity reactions as they increase vascular permeability.

Being that prostaglandins from either pathway, are still fatty acids of a group, they mediate lipid release and controll tissue metabolization, so fat burning is a luxerry of either pathway of formation. It's the pathway from which they are constructed that dictates "trencough". As prostaglandins made from the Cyclooxygenase pathway dictate muscle constriction and platlet aggregation, and the Lipoxygenase pathway dictates bronchial constriction(the main form of expulsion)

[vermin]

Interesting, goose. Does that mean that cabergoline should prevent tren cough?

[Stackertoo]

I wasn't aware that macrophages constricted bronchial tubes.
Very well explained. Guess I need to dig out my old nursing school books!
The quick onset of "The Cough" would be explained by rapid metabolism through the lungs.
Nice read, and very informative. Alot more than I expected to get.
Thanks alot, bro.
Now, where did I leave my "cough syrup"?