Grapefruit and what it does on cycle

**boarderpro1** · 03-23-2007, 04:53 PM

I was reading something about grapfruit juice and being on cycle... the thing is i cant remember if it was beneficial or not appreciate any info about it

**Atomini** · 03-23-2007, 05:06 PM

The only thing I can think of is it makes bowel movements easier... if that contributes anything to your cycle.

**Random** · 03-23-2007, 05:08 PM

Grapefruit contains DHB which is well known to use with orals since it makes orals more effective....not worth adding tho unless youre on orals

CD

**Titleist** · 03-23-2007, 06:48 PM

Originally Posted by CaptainDominate

Grapefruit contains DHB which is well known to use with orals since it makes orals more effective....not worth adding tho unless youre on orals

CD

^^^Exactly. It tastes terrible though...

**guest589745** · 03-23-2007, 06:48 PM

Grapefruit juice makes virtually all drugs moer efficiantly absorbed. 8 ounces can increase effects approx 66% I think. Somethign to do with CYP enzymes blah blah blah I dont really remember but you get it. Be careful.

**Atomini** · 03-23-2007, 07:11 PM

Originally Posted by Skullsmasher

Grapefruit juice makes virtually all drugs moer efficiantly absorbed. 8 ounces can increase effects approx 66% I think. Somethign to do with CYP enzymes blah blah blah I dont really remember but you get it. Be careful.

Actually, I heard of that with pineapple.

**cj1capp** · 03-23-2007, 07:19 PM

Any number of medications can apply to this question: Prozac, BuSpar, Tegretol, Lipitor, Verapamil, Prednisone and a host of others - even Viagra!
A. The reason why grapefruit juice is a problem for people taking certain drugs - including many psychotropic meds - is that grapefruit juice (unlike any other citrus juice) inhibits two enzymes that are important in metabolizing, or breaking down, these medications. When the enzymes aren't doing their job, much more of the drug in question remains available to enter the patient's bloodstream, and in some cases, this can have dangerous, even toxic, effects.
For example, as much as 99% of BuSpar (Buspirone) is normally metabolized before the drug ever enters the bloodstream. When taken in the presence of grapefruit juice (not even at the same time), the amount of BuSpar in the system could increase as much as 400% - a hazardous situation.

According to Graedon's Guide to Grapefruit Interactions, "The grapefruit interaction is long-lasting.

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... investigators have found that the effect is measurable for at least 24 hours and may linger up to two days." This could mean that if a person drank grapefruit juice every day, there would be an extra-strength "grapefruit effect" in his system all the time, as the effect of yesterday's glass might still be lingering when today's glass was drunk.
Besides the ones listed above, psychotropic medications that can be affected to a greater or lesser degree by grapefruit juice include:

Anafranil
Clozaril
Elavil
Halcion
Haldol
Luvoxx
Seroquel
Serzone
Trazodone
Valium
Versed
Zoloft
There are a large number of other types of medications affected by grapefruit juice as well, including all the cholesterol-lowering statins and even some antibiotics and birth control pills. Always read all the literature that accompanies your new prescriptions. Just for example, on my prescription for Zocor, buried three-quarters of the way down in the fifth paragraph, "Cautions," is "Talk with your doctor before including grapefruit or grapefruit juice in your diet while you are taking this medicine." That doesn't seem to me to be a strong enough warning - but at least it's there.
by Marcia Purse

References:

Grapefruit and Prescription Drugs - Mix Carefully - by Mark Bloom
Putting Drug Interactions with Grapefruit Juice in Perspective - by L. Kendall Shaw, PharmD
Using Medications Safely: Interactions Between Grapefruit Juice and Prescription Drugs - by R. Elaine Turner and Gail C. Rampersaud
Grapefruit Juice and Medications: A Potential for Adverse Events
Grapefruit Juice Can Interact With Medicines! - by William C. Shiel, Jr, MD, FACP, FACR

**Random** · 03-23-2007, 07:20 PM

good post thanks CJ

**Titleist** · 03-23-2007, 07:26 PM

Nice post CJ. Thats a good read.

**gehirin** · 03-23-2007, 10:46 PM

In grapefruit, the main effect of blocking the action of the cytochrome enzymes (the enzymes that breakdown drugs) is found in the skin of the grapefruit. So you would want to find a juice that contains the skin too.

Blocking these enzymes (mostly the cytochrome P450 3A4 enzyme) with grapefruit juice will increase the concentration of the drug in the blood/body and increase it's half life (lasts longer). But with oral steroids , this also means an increase in liver damage and liver failure if you take a large dose with grapefruit juice.

Really got to be careful with this because it's difficult to know the limits and what concentrations the steroids are in your body and the amount of liver damage occuring. If you piss turns dark in color, your skin looks yellow, and the white of your eyes yellow...you got big liver problems.

Definitely avoid alcohol and tylenol (acetaminophen) while on oral steroids because alcohol and tylenol are strong agents that damage liver - people die from tylenol. The maximum dose of tylenol is 4000mg/day (2000mg/day for alcoholics)...adding oral roids...who knows