Which AI?? Help please!

[JAY_WD]

Just wanted to know which AI would be best for gyno prevention?

I will be using Durastride before, during and after cycle so i need something to take care of the conversion to estrogen.

Letro?
Armidex?
Aromasin?

Any others?

Please let me know which one would be best and why.

Thanks

[JAY_WD]

Just wanted to know which AI would be best for gyno prevention?

I will be using Durastride before, during and after cycle so i need something to take care of the conversion to estrogen.

Letro?
Armidex?
Aromasin?

Any others?

Please let me know which one would be best and why.

Thanks

bump...

[Merc..]

What compounds are you going to be running on your cycle ??

[JAY_WD]

What compounds are you going to be running on your cycle ??

Just test 500mg pw.

Want an AI to help with gyno sides of Dutastride.

Which one do i get?

[Merc..]

Could try adex at .25 mg ed to start .


Merc.

[Lexed]

rather do 10mg of nolva its cheaper

[JAY_WD]

Could try adex at .25 mg ed to start .


Merc.

Why adex?

Why not any of the other ones?

[Merc..]

rather do 10mg of nolva its cheaper

I definitely agree Lexed ..( much cheaper ) lol


But


He said a AI not a SERM ....



Merc.

[JAY_WD]

Why adex?

Why not any of the other ones?

bump..

[Giants11]

I definitely agree Lexed ..( much cheaper ) lol


But


He said a AI not a SERM ....



Merc.

True......I'll throw in my .02 as well.

Do not run an AI, as that will not prevent gyno, you will still have elevated estrogen due to the fact that you will be on 500mg of Test.

You need to run a SERM so that you block the Estrogen receptor in breat tissue, that way gyno cannot form.

[JAY_WD]

True......I'll throw in my .02 as well.

Do not run an AI, as that will not prevent gyno, you will still have elevated estrogen due to the fact that you will be on 500mg of Test.

You need to run a SERM so that you block the Estrogen receptor in breat tissue, that way gyno cannot form.

Can i run a SERM and an AI together?

If so, what would be the two ideal ones?

[Giants11]

Nolva is ideal for gyno prevention and you can throw in Arimidex if you want that would be fine.

[JAY_WD]

Nolva is ideal for gyno prevention and you can throw in Arimidex if you want that would be fine.

Why Armidex over any of the other SERMS?

[Atomini]

I don't like or trust Arimidex or Letro. They don't deactivate Aromatase permanently. This means you need to taper off Adex or Letro if you use them, otherwise you get estrogen rebound.

None of this happens with Aromasin (Exemestane).

[Giants11]

Why Armidex over any of the other SERMS?

Arimidex is not a SERM and I don't really care which AI you use on cycle. You could go Letro, Adex, Aromasin etc....

The point is to lower estrogen, choose an AI.

[Merc..]

Also wanted to just point out that there is alot of conflicting info on if using nolva with certain 3rd generation AI's that the nolva actually lowers the blood plasma level of the AI. Now there are studies that go back and forth on this . He is a study that shows that nolva does make certain AI's less effective . But like I said one says it does and another says it doesnt ..

This only applies to 3rd generation AI's, Letro, Arimidex and L-Dex.

Interactions of antioestrogens and aromatase inhibitors.

Schmid P, Possinger K

Department of Oncology and Hematology, Charite Campus Mitte, Humboldt University Berlin, Germany.

Aromatase inhibitors and antioestrogens have shown substantial activity in primary and advanced breast cancer. Since they exhibit different modes of action, attempts have been made to combine them or to use them sequentially in order to potentially increase their efficacy. In preclinical studies, combined, sequential or alternating treatments with aromatase inhibitors and antioestrogens have failed to provide higher antitumoural activity. There are relevant pharmacokinetic interactions resulting in decreased plasma concentrations of third generation aromatase inhibitors when combined with tamoxifen. Several randomised clinical trials comparing single agent and combined treatment with tamoxifen and aminoglutethimide failed to show any benefit for the combination. Early results of the adjuvant ATAC trial indicate that single agent anastrozole is superior to tamoxifen or the combination of both. Several trials are ongoing which might help to further define the role of sequential or combined treatment with aromatase inhibitors and antioestrogens. However, to date, looking at the current evidence, combined treatment with aromatase inhibitors and antioestrogens does not appear to provide additional benefit compared to single agent treatment.


Merc.

[Giants11]

I don't like or trust Arimidex or Letro. They don't deactivate Aromatase permanently. This means you need to taper off Adex or Letro if you use them, otherwise you get estrogen rebound.

None of this happens with Aromasin (Exemestane).

Yup, very good point as well.

Which is why I will only use Aromasin during PCT.