Looking for info about HCG and Leydig desensitization.
I've spent the past couple hours looking for info on leydig cell receptor desensitization and the refractory period of that event, after the administration of HCG.
Most of the studies I've found are based off rats obviously, and a lot of them are given around 500iu or more for their tiny bodies. This resulted in huge amounts of receptor desensitization and after a primary increase in plasma testosterone levels they plummeted shortly after due to the refractory period HCG causes.
Something I read by Bill Roberts, and how he is not a fan of HCG, sparked my interest in the impact it could possibly have on the testes and what, if any, permanent damage it may cause to steroidogenesis after a cycle and during PCT. Bill makes a good in saying HCG actually counteracts the bodies GnRH feedback loop by acting like LH, thus not truly restoring it's function.
So, if you've read any interesting studies or have something about this subject... post it up. :7up: