Tamoxifen efficacy variable between individuals

[sarcomere]

Just a reminder, this was in CNN health today.. being breast cancer month and all......


"Certain genetic mutations can virtually shut down a cell's ability to metabolize tamoxifen, dramatically reducing the estrogen-based drug's success in contain�ing tumor-cell growth. Screening women for this enzyme is sparing low responders the expense and time that would be lost trying an ineffective treatment. "


Basically some people may find it works great, others not so much.. just something to keep in mind..

[Atomini]

We're talking about Tamoxifen's (Nolvadex's) uses in breast cancer therapy here, not Nolva's Luteinizing hormone releasing uses. They're also talking about using it for females, not males. So, this claim probably doesn't apply to bodybuilders at all.

[sarcomere]

It's used by both breast cancer patients and body builders for it's properties as a partial agonist / antagonist. Breast cancer patients don't want more breast tissue growing, bodybuilders don't want any breast tissue growing... The LH stimulating effects are due the drugs action on the pituitary as an estrogen antagonist but how is that different from breast caner patients also want the estrogen antagonist properties of the drug..