Libedo Gone

[AST]

When ever i jump on cycle my sex drive just takes a hike, I use Prope and enanthate about 500mg a week. This problem has persisted for over a year now. Its really pissing me off. It just wont stay up. I have tryed experimenting and used HCG for the duration of the cycle. It was successful to a degree but im pretty sure its causing more harm then good, I read that people use ''Caber''
What is this product, Is it pharmaceutical, ? whats the active ingredient ?. And what other options do i have?

Any help will be greatly appreciated, I'm dying over here,

[Merc..]

Yea, steroids can lower t-3 , and , in turn increase prolactin..... which can lower libido... Here is some info on Caber ....




Cabergoline
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Cabergoline
Systematic (IUPAC) name
N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]- 6-(2-propenyl)-8g-ergoline-8-carboxamide
or
1-[(6-allylergolin8β-yl)- carbonyl]-1- [3-(dimethylamino)propyl]-3-ethylurea
Identifiers
CAS number 81409-90-7
ATC code G02CB03 N04BC06
PubChem 54746
DrugBank APRD00836
Chemical data
Formula C26H37N5O2
Mol. mass 451.604 g/mol
Pharmacokinetic data
Bioavailability First-pass effect seen; absolute bioavailability unknown
Protein binding Moderately bound (40% to 42%); concentration- independent
Metabolism Hepatic, predominately via hydrolysis of the acylurea bond or the urea moiety
Half life 63-69 hours (estimated)
Excretion Urine (22%), feces (60%)
Therapeutic considerations
Pregnancy cat. C(US)

Legal status ℞-only(US)

Routes Oral
Cabergoline (brand names Dostinex® and Cabaser®), a lysergic acid amide derivative, is a potent dopamine receptor agonist on D2 receptors.[1] It also acts on dopamine receptors in lactophilic hypothalamus cells to suppress prolactin production in the pituitary gland. It is frequently used as a second-line agent in the management of prolactinomas when bromocriptine is ineffective.

Contents [hide]
1 Pharmacokinetics
2 Carcinogenity
3 Uses
4 Off-label/recreational uses
5 Contraindications and precautions
6 Pregnancy and lactation
7 Side effects
7.1 Valvular heart disease
8 Interactions
9 Dosage
10 References



[edit] Pharmacokinetics
Following a single oral dose, resorption of cabergoline from the gastrointestinal (GI) tract is highly variable, typically occurring within 0.5 to 4 hours. Ingestion with food does not alter its absorption rate. Human bioavailability has not been determined since the drug is intended for oral use only. In mice and rats the absolute bioavailability has been determined to be 30 and 63 percent, respectively. Cabergoline is rapidly and extensively metabolized in the liver and excreted in bile and to a lesser extent in urine. All metabolites are less active than the parental drug or inactive altogether. The human elimination half-life is estimated to be 63 to 68 hours in patients with Parkinson's disease and 79 to 115 hours in patients with pituitary tumors.


[edit] Carcinogenity
In rodents a dose-dependent increase in malignant tumors has been found. The correlation is thought to be species specific. No clinical data exists on carcinogenity in humans.


[edit] Uses
Monotherapy of Parkinson's disease in the early phase.
Combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease.
Adjunctive therapy of prolactin-producing pituitary gland tumors (microprolactinomes).
In some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, and galactorrhea).

[edit] Off-label/recreational uses
It has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs, such as reduced libido and anorgasmia. It also has been suggested online that it has a possible recreational use in reducing or eliminating the male refractory period. It is also used by bodybuilders to control gynecomastia caused by elevated prolactin levels caused by use of anabolic steroids such as Nandrolone.


[edit] Contraindications and precautions
Hypersensitivity to ergot derivatives
Pediatric patients (no clinical experience)
Severely impaired liver function or cholestasis
Co-medication with drugs metabolized mainly by CYP P450 such as erythromycin and ketoconazole, because increased plasma levels of cabergoline may result (although cabergoline undergoes minimal CYP450 metabolism).
Cautions: severe cardiovascular disease, Raynaud's disease, gastroduodenal ulcers, active gastrointestinal bleeding, hypotension.

[edit] Pregnancy and lactation
Pregnancy: Approximately 100 female patients became pregnant under therapy with cabergoline for hyperprolactinemic conditions. The incidence of spontaneous abortions and congenital abnormalities was comparable to nontreated patients. Nevertheless, women wishing to become pregnant should wait a period of four weeks after discontinuation of cabergoline. Patients becoming pregnant under therapy should terminate cabergoline immediately, if possible.
Lactation: In rats cabergoline was found in the maternal milk. Since it is not known if this effect also occurs in humans, breastfeeding women should not be treated.

[edit] Side effects
Approximately 200 patients with newly diagnosed Parkinson's disease participated in a clinical study of cabergoline monotherapy. Seventy-nine (79) percent reported at least one side effect. These side effects were chiefly mild or moderate:

GI tract: Side effects were extremely frequent. Fifty-three percent of patients reported side effects. Very frequent: Nausea (30%), obstipation (22%), and dry mouth (10%). Frequent: Gastric irritation (7%), vomiting (5%), and dyspepsia (2%).
Psychiatric disturbances and central nervous system (CNS): Altogether 51 percent of patients were affected. Very frequent: Sleep disturbances (somnolence 18%, insomnia 11%), vertigo (27%), and depression (13%). Frequent: dyskinesia (4%) and hallucinations (4%).
Cardiovascular: Approximately 30 percent of patients experienced side effects. Most frequent were hypotension (10%), peripheral edema (14%) and non-specific edema (2%). Arrhythmias were encountered in 4.8%, palpitations in 4.3%, and angina pectoris in 1.4%.
In a combinatiion study with 2,000 patients also treated with levodopa, the incidence and severity of side effects was comparable to monotherapy. Encountered side effects required a termination of cabergoline treatment in 15% of patients. Additional side effects were infrequent cases of hematological side effects, and an occasional increase in liver enzymes or serum creatinine without signs or symptoms.

As with other ergot derivatives, pleuritis, exudative pleura disease, pleura fibrosis, lung fibrosis, and pericarditis are seen. These side effects are noted in less than 2% of patients. They require immediate termination of treatment. Clinical improvement and normalization of X-ray findings are normally seen soon after cabergoline withdrawal.

The reported incidence and severity of side effects in hyperprolactinemic patients was comparable.


[edit] Valvular heart disease
In two studies published in the New England Journal of Medicine on January 4, 2007, cabergoline was implicated along with pergolide in causing valvular heart disease.[2][3] Both drugs are ergot-derived dopamine agonists, although their molecular skeletons are different. As a result of this, the FDA removed pergolide from the U.S. market on March 29, 2007.[4] Since cabergoline is not approved in the U.S. for Parkinson's Disease, but for hyperprolactinemia, the drug remains on the market. Treatment for hyperprolactinemia requires lower doses than that for Parkinson's Disease, diminishing the risk of valvular heart disease.


[edit] Interactions
No interactions were noted with levodopa or selegiline. The drug should not be combined with other ergot derivatives. Dopamine antagonists such as antipsychotics and metoclopramide inhibit the clinical action of cabergoline and should therefore not be used concomitantly. The use of antihypertensive drugs should be intensively monitored because excessive hypotension may result from the combination.


[edit] Dosage
Parkinson's disease: Monotherapy: Initial dose should be 0.5 mg daily. The usual maintenance dose is 2 to 4 mg daily. Combination therapy: Usually 2 to 6 mg daily.
Tumors of the pituitary gland and other hyperprolactinemic conditions: Initially 0.5 mg per week, slowly titrated to 4.5 mg per week, if necessary.
Ablactation: According to specific treatment scheme.

[edit] References
^ Dostinex at www.rxlist.com. Retrieved on 2007-04-27.
^ Schade, Rene; Andersohn, Frank & Suissa, Samy et al. (2007-01-04), "Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation", New England Journal of Medicine 356 (1): 29-38, <http://content.nejm.org/cgi/content/full/356/1/29>
^ Zanettini, Renzo; Antonini, Angelo & Gatto, Gemma et al. (2007-01-04), "Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease", New England Journal of Medicine 356 (1): 39-46, <http://content.nejm.org/cgi/content/full/356/1/39>
^ Food and Drug Administration Public Health Advisory (2007-03-29). Retrieved on 2007-04-27.

http://en.wikipedia.org/wiki/Cabergoline


Merc.

[Ashop]

When ever i jump on cycle my sex drive just takes a hike, I use Prope and enanthate about 500mg a week. This problem has persisted for over a year now. Its really pissing me off. It just wont stay up. I have tryed experimenting and used HCG for the duration of the cycle. It was successful to a degree but im pretty sure its causing more harm then good, I read that people use ''Caber''
What is this product, Is it pharmaceutical, ? whats the active ingredient ?. And what other options do i have?

Any help will be greatly appreciated, I'm dying over here,

Have you tried Cialis or Viagra? Are you still on gear?

[duramaxedge]

what about Proviron?

[duramaxedge]

Merc, couldnt he use T3 to lower his prolactin?

[JSola]

Sexually Related Herbs
Sex Drive-Herbs that increase testosterone levels
-Avena (Wild Oats): Increases in men only
-Chrysin: Increases levels in men under 35
-Muira Puama: Increases levels in men; intensifies erections
-Pine Pollen: Increases levels in women
-Siberian Ginseng: Stimulates production in both men and women, also balances
dopamine production in the brain
-Stinging Nettle Root: Keeps testosterone in active form in both men and women
-Tribulus Terrestis (Tribestan): Increases levels in younger men and women
-Ashwaganda: Stabilizes male sex drive; prevents premature ejaculation
-Damiana: Increases sexual desire in women
-Ginseng (Panax Ginseng): Used to stimulate sexual desire in men over 50
-Kava: Mild relaxant, relieves inhibitions
-Passionflower: Relaxes without decreasing sex drive
-Sarsaparilla: Aphrodisiac
-Star Anise: Stimulates women’s sex drive during depression
-Yohimbe: Aphrodisiac for both sexes; increases strength of erection

Impotence-Beneficial herbs
-Ashwaganda: Insures potency and increases fertility
-Catuaba: Strengthens erections; increases erotic dreams and sexual interest
-Cistanche: Enhances production of nitric oxide
-Damiana: Increases stability of erection during intercourse; aphrodisiac
-Epimedium: Increases blood flow to the penis; stimulates the sensory nerves;
increases sexual desire
-Ginkgo: Activates the release of nitric oxide from blood-vessel linings
-Ginseng (Panax Ginseng): Promotes cell growth and healing in the sex organs
-Iporuru: Produces stronger erections and greater numbers of viable sperm
-Morinda: Antidepressant that increases erectile function; also lowers blood pressure
-Muira Puama: Increases both libido and erectile strength
-Yohimbe: Acts to increase blood flow into and reduce blood flow out of penis

Check it out, blend a couple of these guys and you might have a natural hollistic solution

[Merc..]

Merc, couldnt he use T3 to lower his prolactin?

Yes t-3 could help with this......




Merc.

[topnotch]

how long are you staying on gear, and did you do proper pct after your cycles?

[ChrisRock]

but I thought test brings up your sex drive?

[Ashop]

if your still ON...Proviron can really help you. Great for libido.

[abombing]

I like where's my boner thread better than where did my libido go?

[Anaholic]

great info.

[hugovsilva]

When ever i jump on cycle my sex drive just takes a hike, I use Prope and enanthate about 500mg a week. This problem has persisted for over a year now. Its really pissing me off. It just wont stay up. I have tryed experimenting and used HCG for the duration of the cycle. It was successful to a degree but im pretty sure its causing more harm then good, I read that people use ''Caber''
What is this product, Is it pharmaceutical, ? whats the active ingredient ?. And what other options do i have?

Any help will be greatly appreciated, I'm dying over here,

Test shouldn't be causing that, at least during cycle.

What else do you run?

[ACAZORES]

i was using 50mg of proviron a day during the cycle, i woke up everyday with my d**k hard and during the day same think, i finished my cycle and pct and i had more libido during the cycle than now,

[roadapple]

what about Proviron?

bingo! beat me to it

[Njord]

bingo! beat me to it

Yeah by about three days

[roadapple]

Yeah by about three days

heh...sorry i read the post and wasnt aware of the dates/times. wanted to help is all.