Aromasin vs. Arimidex ??

[feanixco]

Are they essentially the same thing? Just planning out my PCT

[Merc..]

Type I suicidal or noncompetitive inhibitors

Type II competitive inhibitors .

Type I inhibitors are steroidal compounds, and type II inhibitors are nonsteroidal drugs.

Aromasin type I AI

Adex type II AI


Merc.

[rabidsquirrel]

most people say use adex during cycle and aromasin during pct

[longhorn814]

aromasin during PCT..

[I_Want_Abs]

aromasin for pct, adex during cycle... if needed

[Brazilian_Juice]

yup, just good luck getting dex that its expensive and hard to find i still havent found it. Thus why I haven't started my cycle.

[I_Want_Abs]

yup, just good luck getting dex that its expensive and hard to find i still havent found it. Thus why I haven't started my cycle.

ummm dude... click on the banner in the top right coner

[magic32]

Are they essentially the same thing? Just planning out my PCT

Not even close, Adex will limit your estro and Mase will kill it. Run some searches for exact percentages. This is why the fellas above said no Mase during cycle (you want some estro).

[Ashop]

Are they essentially the same thing? Just planning out my PCT

AROMASIN is the stronger one of the 2 but both are very good AI's

[legobricks]

Not even close, Adex will limit your estro and Mase will kill it. Run some searches for exact percentages. This is why the fellas above said no Mase during cycle (you want some estro).

If thats the case then why is it recomended that aromasin be run with nolvadex thru PCT? If aromasin is stronger then adex and kills estro wouldnt be along the same lines as femara or "letro"? And letro is usually discouraged thru PCT due to it stopping too much estrogen.... Im curious..

[Merc..]

If thats the case then why is it recomended that aromasin be run with nolvadex thru PCT? If aromasin is stronger then adex and kills estro wouldnt be along the same lines as femara or "letro"? And letro is usually discouraged thru PCT due to it stopping too much estrogen.... Im curious..

Nolva can reduce the blood plasma levels of adex ( a type II AI)..

Aromasin is a type I AI..

Aromasin doesnt need to be present to continue doing its job on the aromatase enzyme..

A type II AI ( which is partially eliminated by nolva) , needs to be present to continue doing its job on the aromatise inhibition.. Once a type I AI does its job the enzyme it is attached to is useless..

Check this study out..

Interactions of antioestrogens and aromatase inhibitors.

Schmid P, Possinger K

Department of Oncology and Hematology, Charite Campus Mitte, Humboldt University Berlin, Germany.

Aromatase inhibitors and antioestrogens have shown substantial activity in primary and advanced breast cancer. Since they exhibit different modes of action, attempts have been made to combine them or to use them sequentially in order to potentially increase their efficacy. In preclinical studies, combined, sequential or alternating treatments with aromatase inhibitors and antioestrogens have failed to provide higher antitumoural activity. There are relevant pharmacokinetic interactions resulting in decreased plasma concentrations of third generation aromatase inhibitors when combined with tamoxifen. Several randomised clinical trials comparing single agent and combined treatment with tamoxifen and aminoglutethimide failed to show any benefit for the combination. Early results of the adjuvant ATAC trial indicate that single agent anastrozole is superior to tamoxifen or the combination of both. Several trials are ongoing which might help to further define the role of sequential or combined treatment with aromatase inhibitors and antioestrogens. However, to date, looking at the current evidence, combined treatment with aromatase inhibitors and antioestrogens does not appear to provide additional benefit compared to single agent treatment

[legobricks]

Ok cool thanx merc! One question tho, why is letro so discouraged during PCT? If your estrogen is stopped too much then doesnt it effect your libido, mood, gains, etc? Just curious if letro is too strong compared to aromasin and adex. Also is letro a type II AI?

[magic32]

Yeah, what Merc said.

Ok cool thanx merc! One question tho, why is letro so discouraged during PCT? If your estrogen is stopped too much then doesnt it effect your libido, mood, gains, etc?
TRUE, SIDE EFFECTS ARE ONE REASON FOR THE DISCOURAGEMENT, BUT ALSO BECAUSE PCT IS THE TIME TO RESTORE HORMONAL BALANCE NOT DISRUPT IT FURTHER. THIS MAKES SERMS IDEAL AS THEY SIMPLY PREVENT ESTRO ATTACHMENT (DUE TO RECEPTOR PREFERENCE) WHILE PERMITTING FREE-ESTRO TO REMAIN IN THE BLOODSTREAM AT NORMAL LEVELS.

Just curious if letro is too strong compared to aromasin and adex.
THE ALLIANCES ABOVE ARE INCORRECT. ADEX IS THE WEAKER THE OTHER TWO ARE SYNONYMOUSLY STRONG.

Surprisingly, not a lot of people seem to know this, but both Letro and Mase are about even strength-wise, e.g. in their ability to reduce estrogen.
Mase:

“Plasma estrogen (estradiol, estrone, and estrone sulfate) seen starting at a 5-mg daily dose of exemestane, with a maximum suppression of at least 85% to 95% achieved at a 25-mg dose.”
http://www.pfizer.com/files/products/uspi_aromasin.pdf & http://www.fda.gov/cder/foi/label/20...753s006lbl.pdf (SEE: Pharmacodynamics)

And at a percentage highly commensurate to that is Letro’s rapid, dose dependent (to reach optimal prevention) suppression rate…

”Femara suppress plasma concentrations of estradiol, estrone, and estrone sulfate by 75%-95% from baseline with maximal suppression achieved within two-three days.” http://www.pharma.us.novartis.com/pr...pdf/Femara.pdf (SEE: Pharmacodynamics)

This also explains why neither is recommended during cycle unless gyno appears and the user prefers not to wait post-cycle (which is acceptable due to rapid response time, and obliteration of symptoms even after elapsed time).

So there you have it.

[legobricks]

Thanks magic!

[magic32]

No problem bru.

[Merc..]

Yeah, what Merc said.



Surprisingly, not a lot of people seem to know this, but both Letro and Mase are about even strength-wise, e.g. in their ability to reduce estrogen.
Mase:

And at a percentage highly commensurate to that is Letro’s rapid, dose dependent (to reach optimal prevention) suppression rate…


This also explains why neither is recommended during cycle unless gyno appears and the user prefers not to wait post-cycle (which is acceptable due to rapid response time, and obliteration of symptoms even after elapsed time).

So there you have it.

Great post ....




Merc.

[bigpapabuff]

My vote is for aromasin.

[magicstick2003]

also letro takes something like 60 days reach saturation levels (can;t think of the word i wanna use) whereas a-dex reaches them in 7. both type II

aromasin, takes seven days and as stated above is a type I (or suicide inhibitor)