What does this have to do with this thread?Quote:
New compound on the way. This is the same gene they knock down in mice/cattle creating incredibly muscular animals:
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4318-22. Epub 2008 Mar 11.
Long-term enhancement of skeletal muscle mass and strength by single gene
administration of myostatin inhibitors.
Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT,
Sahenk Z, Mendell JR, Kaspar BK.
The Research Institute, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Increasing the size and strength of muscles represents a promising therapeutic
strategy for musculoskeletal disorders, and interest has focused on myostatin, a
negative regulator of muscle growth. Various myostatin inhibitor approaches have
been identified and tested in models of muscle disease with varying efficacies,
depending on the age at which myostatin inhibition occurs. Here, we describe a
one-time gene administration of myostatin-inhibitor-proteins to enhance muscle
mass and strength in normal and dystrophic mouse models for >2 years, even when
delivered in aged animals. These results demonstrate a promising therapeutic
strategy that warrants consideration for clinical trials in human muscle
diseases.