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Thread: Regeneration ?

  1. #1
    tensegra1 is offline New Member
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    Regeneration ?

    I would just like to ask if anyone knows if there are any anabolics one could take to stimulate nerve regeneration? I have some nerve damage that is numbing my arms and I'm not crazy about letting someone carve up my back to fix it, not to mention what that would cost. Any help would be appreciated.

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    Schmidty's Avatar
    Schmidty is offline Test Is Best!
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    Dont quote me on this but i think deca stimulates nerve regeneration. One of my best friends is now a parapalegic and was telling me about this... Like i said though, im not 100% about this...

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    Lemonada8's Avatar
    Lemonada8 is offline Knowledgeable Member
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    u can try hgh also, that will stimulate the mast cells... and u can do some spot injections w/ a insulin shot maybe?

    ^^ ditto above, not 100% sure tho

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    MuscleScience's Avatar
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    Quote Originally Posted by Lemonada8 View Post
    u can try hgh also, that will stimulate the mast cells... and u can do some spot injections w/ a insulin shot maybe?

    ^^ ditto above, not 100% sure tho
    Mast cells are involved in histamine release. I think maybe you were meaning glial cells???

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    yeah oops... sorry i was thinkin about my immunology class.... :S

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    peachfuzz is offline Anabolic Member
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    Found this interesting. Hope it helps

    Testosterone enhancement of the nerve cell body response to injury: evidence using in situ hybridization and ribosomal DNA probes

    NB Kinderman and KJ Jones
    Department of Physical Therapy, University of Illinois, Chicago 60612.

    In axotomized peripheral motoneurons capable of successful regeneration, one of the earliest morphological indicators of the injury response occurs within the nucleolus. In the initial part of this investigation, we mapped the nucleolar response of injured adult hamster facial motoneurons from a molecular perspective, utilizing in situ hybridization and ribosomal DNA probes complementary to stable rRNA. Recently, we have discovered that the gonadal steroid, testosterone propionate (TP), accelerates recovery from facial paralysis in the hamster by increasing the rate of regeneration of the fastest regrowing axons. In the second part of this study, the hypothesis that TP accomplishes these effects on facial nerve regeneration through an enhancement of the nerve cell body response to injury was tested using in situ hybridization and rDNA probes. Adult intact male hamsters were subjected to right facial nerve axotomies at the stylomastoid foramen. One-half of the axotomized animals received subcutaneous implants of TP, with the remainder sham implanted. In situ hybridization with tritiated rDNA probes was accomplished and levels of hybridizable rRNA assessed both qualitatively and quantitatively. Axotomy alone induced an upregulation in rRNA levels, with peak changes occurring by 24 hr postoperative and continuing through postoperative day 4. These molecular changes in the nucleolar response preceded, by a full day, any morphological signs of the nucleolar reactive pattern previously found in this cell type, and, as such, point to the usefulness of in situ hybridization as a tool to identify the earliest events associated with the axon reaction. A secondary smaller increase in rRNA levels was observed during the later stages of regeneration. TP significantly augmented the ribosomal response to injury, with levels of rRNA increased as early as 6 hr and the magnitude of the response greater than that occurring following axotomy alone. These results provide the first mechanistic step in the identification of the cellular processes underlying gonadal steroid augmentation of neuronal reparative processes. We conclude that TP accelerates the "switch" from a normal to a reparative state and suggest that this priming effect may be causally related to the differential effects of TP on the regenerative properties of this cell type.
    Last edited by peachfuzz; 04-27-2008 at 04:45 PM.

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