Letro detection time

[The_Canibal]

Does anybody have a clue? didn't find anything on the net so far ...

[magic32]

Good question.

Letro's half-life is about 6 hrs, this means its terminal half-life (last one, or 8th incidence) is experienced at around 48 hrs. Now generally speaking, and note I said "generally" you are supposed to Septuple (seven-fold) the terminal half-life to account for ALL residual metabolite degradation, i.e. upper limit detection times. This gives us 336 hrs or about 14 days.



However, because Letro is pharmacologically odd in that concentrations are somewhat non-linear, i.e. continuous accumulation doesn't occur past a specific point (at least in doses up to 2.5mgs ED), I'd say it would degrade even more rapidly.

http://www.pharma.us.novartis.com/pr...pdf/Femara.pdf

[Phate]

Good question.

Letro's half-life is about 6 hrs, this means its terminal half-life (last one, or 8th incidence) is experienced at around 48 hrs. Now generally speaking, and note I said "generally" you are supposed to Septuple (seven-fold) the terminal half-life to account for ALL residual metabolite degradation, i.e. upper limit detection times. This gives us 336 hrs or about 14 days.



However, because Letro is pharmacologically odd in that concentrations are somewhat non-linear, i.e. continuous accumulation doesn't occur past a specific point (at least in doses up to 2.5mgs ED), I'd say it would degrade even more rapidly.

http://www.pharma.us.novartis.com/pr...pdf/Femara.pdf

great post, i love chemistry and it's nice to see posted that use scientific data as most of yours do, looking forward to reading more of your posts

[The_Canibal]

Good question.

Letro's half-life is about 6 hrs, this means its terminal half-life (last one, or 8th incidence) is experienced at around 48 hrs. Now generally speaking, and note I said "generally" you are supposed to Septuple (seven-fold) the terminal half-life to account for ALL residual metabolite degradation, i.e. upper limit detection times. This gives us 336 hrs or about 14 days.



However, because Letro is pharmacologically odd in that concentrations are somewhat non-linear, i.e. continuous accumulation doesn't occur past a specific point (at least in doses up to 2.5mgs ED), I'd say it would degrade even more rapidly.

http://www.pharma.us.novartis.com/pr...pdf/Femara.pdf

wow ... amazing

but still 2 weeks? that doesn't do much good to me, as i intended to use it along my suspension to avoid the bloating

[Phate]

wrong info

[Phate]

wow ... amazing

but still 2 weeks? that doesn't do much good to me, as i intended to use it along my suspension to avoid the bloating

the water retention from the suspension should discipate quickly due to the nature of suspension's half life