Cabaser !!!!

[bbminded]

anyone ever use this product???

[Big]

Yes, many people have.

[bbminded]

any opinions the negs and positives !!!!!

[Merc..]

What is casper ?? Do you mean Caber ??? lol ??

[Big]

What is casper ?? Do you mean Caber ??? lol ??

Cabaser = cabergoline

[Merc..]

Cabaser = cabergoline

I tought caber = cabergoline .. lol ...

[Merc..]

I thought CA baser was a baser from cali .. lol .... lol .... heheheheh

[Merc..]

Caber is good .. What compounds are you using ?? caber is good for controlling prolacin ...

I have used it at 250 mcg , two times per week ...


Merc.

[Big]

What is casper ??

Here ya go Merc

[Merc..]

Here ya go Merc

ahhh , Casper , the friendly ghost ....

[bbminded]

what positives do you get with using it???

[james21]

I have had a whole lot of experience with caber, love it

Cabergoline/Dostinex Information

etc etc, I think its one of the best things you dont need a large dose at all plus the sides are awesome Ive commented many times on caber

[Merc..]

Here Ya go BBminded...


Cabergoline
From Wikipedia, the free encyclopedia
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Cabergoline
Systematic (IUPAC) name
N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]- 6-(2-propenyl)-8g-ergoline-8-carboxamide
or
1-[(6-allylergolin8β-yl)- carbonyl]-1- [3-(dimethylamino)propyl]-3-ethylurea
Identifiers
CAS number 81409-90-7
ATC code G02CB03 N04BC06
PubChem 54746
DrugBank APRD00836
Chemical data
Formula C26H37N5O2
Mol. mass 451.604 g/mol
Pharmacokinetic data
Bioavailability First-pass effect seen; absolute bioavailability unknown
Protein binding Moderately bound (40% to 42%); concentration- independent
Metabolism Hepatic, predominately via hydrolysis of the acylurea bond or the urea moiety
Half life 63-69 hours (estimated)
Excretion Urine (22%), feces (60%)
Therapeutic considerations
Pregnancy cat. C(US)

Legal status ℞-only(US)

Routes Oral
Cabergoline (brand names Dostinex® and Cabaser®), a lysergic acid amide derivative, is a potent dopamine receptor agonist on D2 receptors.[1] It also acts on dopamine receptors in lactophilic hypothalamus cells to suppress prolactin production in the pituitary gland. It is frequently used as a second-line agent in the management of prolactinomas when bromocriptine is ineffective.

Contents [hide]
1 Pharmacokinetics
2 Carcinogenity
3 Uses
4 Off-label/recreational uses
5 Contraindications and precautions
6 Pregnancy and lactation
7 Side effects
7.1 Valvular heart disease
8 Interactions
9 Dosage
10 References



[edit] Pharmacokinetics
Following a single oral dose, resorption of cabergoline from the gastrointestinal (GI) tract is highly variable, typically occurring within 0.5 to 4 hours. Ingestion with food does not alter its absorption rate. Human bioavailability has not been determined since the drug is intended for oral use only. In mice and rats the absolute bioavailability has been determined to be 30 and 63 percent, respectively. Cabergoline is rapidly and extensively metabolized in the liver and excreted in bile and to a lesser extent in urine. All metabolites are less active than the parental drug or inactive altogether. The human elimination half-life is estimated to be 63 to 68 hours in patients with Parkinson's disease and 79 to 115 hours in patients with pituitary tumors. Average elimination half-life is 80h.


[edit] Carcinogenity
In rodents a dose-dependent increase in malignant tumors has been found. The correlation is thought to be species specific. No clinical data exists on carcinogenity in humans.[citation needed]


[edit] Uses
Monotherapy of Parkinson's disease in the early phase.
Combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease.
Adjunctive therapy of prolactin-producing pituitary gland tumors (microprolactinomas).
In some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, and galactorrhea).

[edit] Off-label/recreational uses
It has at times been used as an adjunct to SSRI antidepressants as there is some evidence that it counteracts certain side effects of those drugs, such as reduced libido and anorgasmia. It also has been suggested online that it has a possible recreational use in reducing or eliminating the male refractory period. It is also used by bodybuilders to control gynecomastia caused by elevated prolactin levels caused by use of anabolic steroids such as Nandrolone .


[edit] Contraindications and precautions
Hypersensitivity to ergot derivatives
Pediatric patients (no clinical experience)
Severely impaired liver function or cholestasis
Co-medication with drugs metabolized mainly by CYP P450 such as erythromycin and ketoconazole, because increased plasma levels of cabergoline may result (although cabergoline undergoes minimal CYP450 metabolism).
Cautions: severe cardiovascular disease, Raynaud's disease, gastroduodenal ulcers, active gastrointestinal bleeding, hypotension.

[edit] Pregnancy and lactation
Pregnancy: Approximately 100 female patients became pregnant under therapy with cabergoline for hyperprolactinemic conditions. The incidence of spontaneous abortions and congenital abnormalities was comparable to nontreated patients. Nevertheless, women wishing to become pregnant should wait a period of four weeks after discontinuation of cabergoline. Patients becoming pregnant under therapy should terminate cabergoline immediately, if possible.
Lactation: In rats cabergoline was found in the maternal milk. Since it is not known if this effect also occurs in humans, breastfeeding women should not be treated.

[edit] Side effects
Approximately 200 patients with newly diagnosed Parkinson's disease participated in a clinical study of cabergoline monotherapy. Seventy-nine (79) percent reported at least one side effect. These side effects were chiefly mild or moderate:

GI tract: Side effects were extremely frequent. Fifty-three percent of patients reported side effects. Very frequent: Nausea (30%), obstipation (22%), and dry mouth (10%). Frequent: Gastric irritation (7%), vomiting (5%), and dyspepsia (2%).
Psychiatric disturbances and central nervous system (CNS): Altogether 51 percent of patients were affected. Very frequent: Sleep disturbances (somnolence 18%, insomnia 11%), vertigo (27%), and depression (13%). Frequent: dyskinesia (4%) and hallucinations (4%).
Cardiovascular: Approximately 30 percent of patients experienced side effects. Most frequent were hypotension (10%), peripheral edema (14%) and non-specific edema (2%). Arrhythmias were encountered in 4.8%, palpitations in 4.3%, and angina pectoris in 1.4%.
In a combinatiion study with 2,000 patients also treated with levodopa, the incidence and severity of side effects was comparable to monotherapy. Encountered side effects required a termination of cabergoline treatment in 15% of patients. Additional side effects were infrequent cases of hematological side effects, and an occasional increase in liver enzymes or serum creatinine without signs or symptoms.

As with other ergot derivatives, pleuritis, exudative pleura disease, pleura fibrosis, lung fibrosis, and pericarditis are seen. These side effects are noted in less than 2% of patients. They require immediate termination of treatment. Clinical improvement and normalization of X-ray findings are normally seen soon after cabergoline withdrawal.

The reported incidence and severity of side effects in hyperprolactinemic patients was comparable.


[edit] Valvular heart disease
In two studies published in the New England Journal of Medicine on January 4, 2007, cabergoline was implicated along with pergolide in causing valvular heart disease.[2][3] Both drugs are ergot-derived dopamine agonists, although their molecular skeletons are different. As a result of this, the FDA removed pergolide from the U.S. market on March 29, 2007.[4] Since cabergoline is not approved in the U.S. for Parkinson's Disease, but for hyperprolactinemia, the drug remains on the market. Treatment for hyperprolactinemia requires lower doses than that for Parkinson's Disease, diminishing the risk of valvular heart disease.


[edit] Interactions
No interactions were noted with levodopa or selegiline. The drug should not be combined with other ergot derivatives. Dopamine antagonists such as antipsychotics and metoclopramide inhibit the clinical action of cabergoline and should therefore not be used concomitantly. The use of antihypertensive drugs should be intensively monitored because excessive hypotension may result from the combination.


[edit] Dosage
Parkinson's disease: Monotherapy: Initial dose should be 0.5 mg daily. The usual maintenance dose is 2 to 4 mg daily. Combination therapy: Usually 2 to 6 mg daily.
Tumors of the pituitary gland and other hyperprolactinemic conditions: Initially 0.5 mg per week, slowly titrated to 4.5 mg per week, if necessary.
Ablactation: According to specific treatment scheme.

[edit] References
^ Dostinex at www.rxlist.com. Retrieved on 2007-04-27.
^ Schade, Rene; Andersohn, Frank & Suissa, Samy et al. (2007-01-04), "Dopamine Agonists and the Risk of Cardiac-Valve Regurgitation", New England Journal of Medicine 356 (1): 29-38, <http://content.nejm.org/cgi/content/full/356/1/29>
^ Zanettini, Renzo; Antonini, Angelo & Gatto, Gemma et al. (2007-01-04), "Valvular Heart Disease and the Use of Dopamine Agonists for Parkinson's Disease", New England Journal of Medicine 356 (1): 39-46, <http://content.nejm.org/cgi/content/full/356/1/39>
^ Food and Drug Administration Public Health Advisory (2007-03-29). Retrieved on 2007-


http://en.wikipedia.org/wiki/Cabergoline



Merc.

[james21]

brings prolactin to null lowers prog, increases sex drive, size etc(in my experience) although i dont need it hah. Refraction period is much shorted its a great drug i used it to get rid of prog gyno. and it works GREAT and you dont need but .5mg e3d

[james21]

and this is all from first hand experience

[Merc..]

brings prolactin to null lowers prog, increases sex drive, size etc(in my experience) although i dont need it hah. Refraction period is much shorted its a great drug i used it to get rid of prog gyno. and it works GREAT and you dont need but .5mg e3d

Yea I used it at 250 mcg two times per week .. It does work very well at lowering prolactin .. And increses sex drive .. as well as dopamine ...

[bbminded]

the positives sound awesome however what about the possible neg sides fainting, lack of energy lowered blood pressure???

[bbminded]

so does it almost work as an anti depressent then and is it good to use while on a cycle or post cycle??

[james21]

no it dosent work like an antidepressant, its good to use on cycle if your using a 19nor neg side effects have been heart problems but those studies where up to 6mg/day for years

[bbminded]

so it would not be needed on say a prop. mast cycle then??? how about with pct??

[bbminded]

Is there any reason to take it when not on a cycle??

[BITTAPART2]

i take it post cycle to shke off prolactin caused by 19nors. Also helps with libio issues post cycle. so no, it can be used both ways. The oral suspensions sold on research sites are garbage compared to the pills, trust me. All the reps from sites that carry it are going to chime in now but the chemical should not be suspended in water or PEG as it does break down this way.