Stacking T4 AND T3

[G-Force]

is there any point?

what are the positives and negatives?

i am talking about stacking these two while on AAS and hgh cycles BTW

[guitarzan]

Bump

[jstraw428]

I dont think you really need to stack these two together.....You would be fine just running the T3.....and then maybe you could switch to the T4 after yourcycle just to maintain what you have lost......

I personally hate T4, i find it a lot hardr to get the results i want, in the time i want.....I strictly use T3.....and love it....

[G-Force]

i use t4 while on hgh

t4 is said to be better than t3 while cycling hgh

as it is the chemical that is released while the t4 gets converted into t3 that is needed to make hgh more potent (i forget the name of the chemical - but using t3 alone wont release it)

anyway i always use t4 on hgh but have aquired some t3 and wondered if it was worth while adding into the mix
i only have enough for 25mcg for 12 days or 12.5mcg for 24 days

[Drake Hotel]

In any case it sounds like you should get more T3. The tabs you have you could use 50mcg 1 hour pre-workout. (Yeah for a different purpose than you intended with the T3, but still.)

[jstraw428]

25mcg of T3 wont do anything, your body produces about that much naturally.....a minimum of 50mcg should be used.....i run it at 75mcg-100mcg ed.......

I would not run both at the same time......

[G-Force]

25mcg of T3 wont do anything, your body produces about that much naturally.....a minimum of 50mcg should be used.....i run it at 75mcg-100mcg ed.......

I would not run both at the same time......

i only run 50mcg of T4

dont like going high on thryoid meds

i have never used T3 but have gone as high as 150mcg on T4 but didint notice much difference to be honest

12.5mcg of T3 equates to around 50mcg of T4 does it not?

so if i take both this may be of worth?

[Drake Hotel]

i only run 50mcg of T4

dont like going high on thryoid meds

i have never used T3 but have gone as high as 150mcg on T4 but didint notice much difference to be honest

12.5mcg of T3 equates to around 50mcg of T4 does it not?

so if i take both this may be of worth?

Only 50mcg T4? Isn't endogenous production 75mcg/d? In that case you're shutting down endogenous production and establishing a lower serum level.

[jstraw428]

I agree partly with Drake on this one.... You are shutting natural production down, and replacing it with even lower levels...... T3 is also a lot more potent than T4, and I believe easier to use to acheive desired results.....
I wouldn't take T4 at anything less tha 150mcg.....JMO....

[G-Force]

bump
can anyone else confirm - is engogenous production of T4 really 75mcg a day?

[Roshambo]

Only 50mcg T4? Isn't endogenous production 75mcg/d? In that case you're shutting down endogenous production and establishing a lower serum level.

The thyroid gland produces three hormones -- thyroxine (tetraiodothyronine, T4), triiodothyronine (T3), and calcitonin. Calcitonin is primarily employed in bone homeostasis. The overall effect of the thyroid hormones T3 and T4 include necessary actions that contribute to growth, development, control of body temperature, and energy levels through control of basal metabolic processes.

Biosynthesis -- Iodine is a vital component of the hormones. A minimum dietary intake of 75 mcg is required for the daily production of thyroid hormones. (The USRDA for iodine is 150 mcg.) Dietary iodide is taken up by the thyroid gland by specialised transport systems in a process called iodide trapping. Once in the gland, iodide is converted to iodine by thyroidal peroxidase enzymes (which may be inhibited by elevated levels of iodine, as described below). The iodine is then combined with residues of the amino acid tyrosine to form mono-iodotyrosine (MIT) and di-iodotyrosine (DIT). With the products becoming incorporated into thyroglobulin, the thyroid storage sites of thyroid hormones. This process is termed iodide organification. The MIT and DIT may then combine to form tri- and tetra-iodothyronine (MIT + DIT --> triiodothyronine & DIT + DIT --> tetraiodothyronine). This occurs in a ratio of approximately 5:1 (5 T4 : 1 T3).

Release and Pharmacokinetics -- Upon stimulation by TSH, the thyroid hormones are released by a combination of proteolysis of thyroglobulin, freeing the hormone, and exocytosis (released into the circulation). Circulating thyroid hormone is highly bound (>99%) to thyroid binding globulin. (RECALL that œstrogens will increase and androgens decrease circulating levels of TBG.) Circulating levels of T4 and T3 closely match the ratios of the production, with the ratio of 4:1 (T4:T3). The active biological half-life of these hormones are 7 days for T4 and 1 day for T3. Thyroid hormones are then taken up by cells throughout the body where they may exert their effect. Once in the cell T4 is metabolised to T3 or inactive metabolites (this conversion also occurs in the thyroid and plasma, but to a lesser extent) by the enzyme iodinase

[alextg]

I think you should better ask on the HGH thread cause you're on hgh as you say ... Gear should most probably know about this :-) But as far as i know , while on HGH , you use T4

[G-Force]

The thyroid gland produces three hormones -- thyroxine (tetraiodothyronine, T4), triiodothyronine (T3), and calcitonin. Calcitonin is primarily employed in bone homeostasis. The overall effect of the thyroid hormones T3 and T4 include necessary actions that contribute to growth, development, control of body temperature, and energy levels through control of basal metabolic processes.

Biosynthesis -- Iodine is a vital component of the hormones. A minimum dietary intake of 75 mcg is required for the daily production of thyroid hormones. (The USRDA for iodine is 150 mcg.) Dietary iodide is taken up by the thyroid gland by specialised transport systems in a process called iodide trapping. Once in the gland, iodide is converted to iodine by thyroidal peroxidase enzymes (which may be inhibited by elevated levels of iodine, as described below). The iodine is then combined with residues of the amino acid tyrosine to form mono-iodotyrosine (MIT) and di-iodotyrosine (DIT). With the products becoming incorporated into thyroglobulin, the thyroid storage sites of thyroid hormones. This process is termed iodide organification. The MIT and DIT may then combine to form tri- and tetra-iodothyronine (MIT + DIT --> triiodothyronine & DIT + DIT --> tetraiodothyronine). This occurs in a ratio of approximately 5:1 (5 T4 : 1 T3).

Release and Pharmacokinetics -- Upon stimulation by TSH, the thyroid hormones are released by a combination of proteolysis of thyroglobulin, freeing the hormone, and exocytosis (released into the circulation). Circulating thyroid hormone is highly bound (>99%) to thyroid binding globulin. (RECALL that œstrogens will increase and androgens decrease circulating levels of TBG.) Circulating levels of T4 and T3 closely match the ratios of the production, with the ratio of 4:1 (T4:T3). The active biological half-life of these hormones are 7 days for T4 and 1 day for T3. Thyroid hormones are then taken up by cells throughout the body where they may exert their effect. Once in the cell T4 is metabolised to T3 or inactive metabolites (this conversion also occurs in the thyroid and plasma, but to a lesser extent) by the enzyme iodinase

so 75mcg of ioding is needed for thyroid function

doesnt say anything about natural production of T4 being 75mcg

perhaps this is what Drake was getting confused with

75mcg of T4 seems a lot to be producing naturally

[Drake Hotel]

so 75mcg of ioding is needed for thyroid function

doesnt say anything about natural production of T4 being 75mcg

perhaps this is what Drake was getting confused with

75mcg of T4 seems a lot to be producing naturally

No.

there is good agreement that about 1/3 of T4 daily produced (~130 nmol) in normal humans is converted to T3, which corresponds to about 40 nmol and thus 80% of the estimated total daily T3 production of 50 nmol.

http://www.thyroidmanager.org/Chapter3/3c/3c-frame.htm

130nmol T4 = ~101mcg

50nmol T3 = ~32.5mcg

[magic32]

Nope!

is there any point?
NOT UNLESS YOU'RE USING A MEDICINAL BLEND TO EFFECTIVELY SUPPLEMENT AND RESTORE NORMAL OUTPUT.

what are the positives and negatives?
REDUNDANCY.
ALTHOUGH IT DOES POSSESS OTHER FUNCTIONS, FOR OUR PURPOSES T4 CAN BEST BE DESCRIBED AS A T3 PRECURSOR.

By the way, T4 is produced solely by the thyroid gland which daily produces approximately 80-100 mcgs. The bulk of T3 (80%) is metabolized from T4 (what I meant above by precursor) a process of the liver and kidneys, not the thyroid.

More on T-hormones:
http://www.fda.gov/cder/foi/nda/2000...hroid_medr.pdf

[Ashop]

theres a few brands out with T3/T4 combo.