AI Rebound EFfect

[reddragon4954]

Been doing some research and was wondering if someone could shed some light on this.

I have heard that AI's such as letro and armidex can cause an estrogen rebound effect, but Aromasin there will be no rebound effect?

Is this true, Aromasin has no rebound effect?

[LATS60]

Been doing some research and was wondering if someone could shed some light on this.

I have heard that AI's such as letro and armidex can cause an estrogen rebound effect, but Aromasin there will be no rebound effect?

Is this true, Aromasin has no rebound effect?

Yes it's true.
Both anastrozole and letrozole are type II nonsteroidal AIs, whereas exemestane has a steroidal structure and is classified as a type I AI, also known as an aromatase inactivator because it irreversibly binds with and permanently inactivates the enzyme.

[reddragon4954]

bump

[LATS60]

bump

Honest, i'm not telling lies mate.
That post is not my opinion, it's a pharmacological fact.

[reddragon4954]

so even if Im paranoid about gyno and running 50mg ED of aromasin, there will still be no rebound effect then?

[LATS60]

so even if Im paranoid about gyno and running 50mg ED of aromasin, there will still be no rebound effect then?

As aromasin lowers estrogen by around 85% then it's a pretty good AI to use on cycle for gyno. It's also a good AI for use in PCT because it makes the aromatase enzyme inactive, however there will come a point were there has to be some rebound, when and/or how much i cannot possibly say.
You would have to get into the molecular mechanisms of aromatase reaction.
This is an extremely complicated issue, aromasin has been shown to be very potent and specific, but the structural basis of drug recognition by aromatase has remained elusive because the three-dimensional structure of this enzyme hasn't been determined.
So even the molecular endochronologist don't yet know exactly how this works.
But after writing all that, gyno should not be an issue if you take the right precautions.

[reddragon4954]

would nolva 20mg ED be enough to combat the rebound

[LATS60]

would nolva 20mg ED be enough to combat the rebound

Your missing the point. What are you going to take to combat the rebound when you stop taking the nolva?
As i said at the end of my last post, you wont get gyno if you run an AI on cycle. Then just run a standard PCT and throw some aromasin in if you like.

[reddragon4954]

Been doing more research and it appears that since aromasin binds to the estrogen and makes its useless, that there should be no rebound effect.

Still need a yes or no answer as to whether aromasin has a rebound effect.? From what I understadn though there should be no estrogen rebound right?

PCT

Nolva wk1-4 20mg ed
Aromasin wk 1-6 25mg ED

What do you think?

[THEMEATEATER]

Lats what do you use during cycle?
I've been using 10mg nolva ed but only because I couldnt get arimidex. But now I have got the problem sorted I'm thinking of getting liquidstane.

[LATS60]

Been doing more research and it appears that since aromasin binds to the estrogen and makes its useless, that there should be no rebound effect.

Still need a yes or no answer as to whether aromasin has a rebound effect.? From what I understadn though there should be no estrogen rebound right?

PCT

Nolva wk1-4 20mg ed
Aromasin wk 1-6 25mg ED

What do you think?

Arrrggghhh, post #6, ask a molecular endo.

MEAT, Pm'd you.

[jc95605]

use adex while on cycle and aromsin while in pct.