Thread: Nolvadex question
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01-30-2009, 06:38 PM #1Associate Member
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01-30-2009, 07:02 PM #2
Letro is the only one known to "possibly" (keyword here is possibly) shrink gyno and that is because it eliminates estrogen up to 95-98% in the body sometimes to the point where its non-existent.
Nolva, just prevents the estrogen from binding to form gyno, it really won't do anything after the gyno has been there for several years.
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01-30-2009, 07:37 PM #3
wrong forum. Should be in the pct forum.
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01-30-2009, 07:46 PM #4Banned ~ Scammer
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actually i dont think letro will do anything for existing gyno..... .. havent seen any studies that show this...shrink yes. but gonna look now... lol
there are several studies using nolvadex on patients with pubertal gyno..
raloxifene seems to work even better.. heres one..
Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia .Lawrence SE, Faught KA, Vethamuthu J, Lawson ML.
Department of Pediatrics, University of Ottawa, Ontario, Canada. [email protected]
OBJECTIVES: To assess the efficacy of the anti-estrogens tamoxifen and raloxifen in the medical management of persistent pubertal gynecomastia. STUDY DESIGN: Retrospective chart review of 38 consecutive patients with persistent pubertal gynecomastia who presented to a pediatric endocrinology clinic. Patients received reassurance alone or a 3- to 9-month course of an estrogen receptor modifier (tamoxifen or raloxifene). RESULTS: Mean (SD) age of treated subjects was 14.6 (1.5) years with gynecomastia duration of 28.3 (16.4) months. Mean reduction in breast nodule diameter was 2.1 cm (95% CI 1.7, 2.7, P <.0001) after treatment with tamoxifen and 2.5 cm (95% CI 1.7, 3.3, P <.0001) with raloxifene. Some improvement was seen in 86% of patients receiving tamoxifen and in 91% receiving raloxifene, but a greater proportion had a significant decrease (>50%) with raloxifene (86%) than tamoxifen (41%). No side effects were seen in any patients. CONCLUSION: Inhibition of estrogen receptor action in the breast appears to be safe and effective in reducing persistent pubertal gynecomastia, with a better response to raloxifene than to tamoxifen. Further study is required to determine that this is truly a treatment effect.
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01-30-2009, 08:58 PM #5
Look at the study, it states the mean age of the subjects was "14.6" roughly 15 years old. It's one thing to use Nolva to treat gyno during puberty and its another thing entirely to try to treat it years later when your in your twenties (I assume the OP friend is around 20) because nolva doesn't try to actually control estrogen levels which makes it a good medication because during purberty hromone levels are fluctuating and giving teenagers pharmaceutical AI's can mess up the bodies natural hormonal stablization process.
However, when your 20 or older its a different ballgame, Nolva blocks the estrogen from touching the breast to form gyno but that doesn't mean gyno can't feed off the estrogen levels already present in the body. While Letro prevents the aromatization of estrogen almost completely thus making estrogen reaching the breast almost a nonexistent possibility because estrogen levels are so very low.
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01-30-2009, 09:25 PM #6Banned ~ Scammer
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oh i hear what your saying..not arguing the point.. and i have known in some cases where letro has shrunk lumps that were already formed.. same with nolvadex .. the puffyness is still hard to get rid of though..
also understand your theory about stopping aromatization..
would just like to see a actual study using letro in regards to gyno..
have only seen studies with nolvadex in these instances..
not sure either one will rid one totally of gyno..just shrink the lumps to the point where it isnt as noticable.. i feel once the lumps have formed. you will most likely need surgery to eliminate the problem.. it will come back if precautions are not taken.
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01-30-2009, 09:37 PM #7
Yeah, using letro to treat gyno after its formed is a crap shoot. In the majority of cases it doesn't work, for some reason some people are able to shrink to the point its not noticeable. But I agree, the gyno is still there, breast tissue cannot be metabolized by the body so it might just be "scattered in pieces" (just guessing) and when you keep doing AAS it can feed off it and grow again.
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01-30-2009, 10:06 PM #8
Letro did successfully cure some gyno I formed behind my one nipple. Definitely worth a shot, what do you have to lose.
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01-30-2009, 10:08 PM #9Banned ~ Scammer
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agree there.. id hit it with everything i got before i went under the knife..
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04-10-2009, 04:19 PM #10New Member
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i have gyno as well and thinking of trying letro before i consider going under the knife, only thing that bothers me is my sex drive would be shot, is there anyway of getting around this, i was thinking maybe proviron ??
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