Diminished benfits/gains after 8 weeks?

[ezlimitz]

I have been reading that after running a cycle for (and this is sort of vague) 7-10 weeks the gains that a person may have noticed being rather significiant initially will diminish.

I have read different thoughts on this that it could be due to the body countering the elevated levels of hormones or ..whatever.

I probably have read something on this board too but cannot find it.

My point is that after about 8 weeks on 600 test cyp a week and 200 npp 3tw I feel like I am not on a cycle. Strenght seems to have diminished somewhat compared to say two weeks ago, not as aggressive, and so on.

Could be a bad vial of test...could be over training....could be that my body is countering the elevated levels of new stuff.

What are your experiences?

Terry

[redz]

I have yet to experience any diminishing gains myself with cycles upto 13 weeks.

[ninesecz]

Most people see the best results from week 6-10 fter week 10 the next few weeks are ususually to help solidify the gains but most of the time by then , the gains have slowly leveled off. With Cyp, you should have just started getting gain 3-4 weeks ago. I do not think it should be tapering off already. If it is I would look at my training, and diet, maybe you need to take a week (eveen 3-5days) off. Up your calories to rediculously high levels for a week. Basically shock your body and mucles! this should bang you out of you Platuea cause IMO in week 8, you should still be getting decent gains.! Myself , I do not even feel the full effects of Cyp until week 6

[redz]

one of three things is possible:
1-diet and training are off
2-high estrogen sides
3-your gear is underdosed or bunk

[Dancer]

Are you reading about the upregulation of myostatin after day 56, or are you ref to something else?

[ezlimitz]

Thanks Dancer,

Thats what I was trying to find...the myostatin threads I had seen...only because I was feeling a little "deflated" relative to what was happening up until say a week ago.

I have been hitting the gym pretty hard and perhaps over training....lots of possibilities...

Just looking for insights from others too.

Thanks

Terry

[Dancer]

Its on this boards and a few others... Admin does not want links to other boards for any other threads due to this board's rules.

But in basic the study stated that post day 56 your body will upreg the production of myostatin which will slow down and eventually kill your gain.

[Swifto]

Its on this boards and a few others... Admin does not want links to other boards for any other threads due to this board's rules.

But in basic the study stated that post day 56 your body will upreg the production of myostatin which will slow down and eventually kill your gain.

Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration.

Lakshman KM, Bhasin S, Corcoran C, Collins-Racie LA, Tchistiakova L, Forlow SB, St Ledger K, Burczynski ME, Dorner AJ, Lavallie ER.

Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States.

Methodological problems, including binding of myostatin to plasma proteins and cross-reactivity of assay reagents with other proteins, have confounded myostatin measurements. Here we describe development of an accurate assay for measuring myostatin concentrations in humans. Monoclonal antibodies that bind to distinct regions of myostatin served as capture and detector antibodies in a sandwich ELISA that used acid treatment to dissociate myostatin from binding proteins. Serum from myostatin-deficient Belgian Blue cattle was used as matrix and recombinant human myostatin as standard. The quantitative range was 0.15-37.50 ng/mL. Intra- and inter-assay CVs in low, mid, and high range were 4.1%, 4.7%, and 7.2%, and 3.9%, 1.6%, and 5.2%, respectively. Myostatin protein was undetectable in sera of Belgian Blue cattle and myostatin knockout mice. Recovery in spiked sera approximated 100%. ActRIIB-Fc or anti-myostatin antibody MYO-029 had no effect on myostatin measurements when assayed at pH 2.5. Myostatin levels were higher in young than older men (mean+/-S.E.M. 8.0+/-0.3 ng/mL vs. 7.0+/-0.4 ng/mL, P=0.03). In men treated with graded doses of testosterone , myostatin levels were significantly higher on day 56 than baseline in both young and older men; changes in myostatin levels were significantly correlated with changes in total and free testosterone in young men. Myostatin levels were not significantly associated with lean body mass in either young or older men. CONCLUSION: Myostatin ELISA has the characteristics of a valid assay: nearly 100% recovery, excellent precision, accuracy, and sufficient sensitivity to enable measurement of myostatin concentrations in men and women.
PMID: 19356623 [PubMed - in process]


The body will begin to build a tolerance. Myostatin, SHBG and other factors (not understood) are to blame.

Increase doses, add other compounds, change training volume/intensity and reduce SHBG is my advice.

[Dancer]

/\ good addy... thanks swift

[Aodha]

I have yet to experience any diminishing gains towards the end. I feel good all the way through my cycle. Interesting stuff.