Yes i do agree however, I found htis info and it clearly states long term use and abrupt cessation of the drug AFTER long term, can lead to addison's disease..I don' thtink a six day dose pack with accurate dosage per day instructions can lead to addisons disease, art least not according to this:
http://www.absoluteastronomy.com/top...ylprednisolone is a synthetic glucocorticoidGlucocorticoid
Glucocorticoids are a class of steroid hormones which bind to the glucocorticoid receptor , which is present in almost every animal cell.GCs are part of the feedback mechanism in the immune system which turns immune activity down....
drug. It is sold in the USA and Canada under the brand names Phocenta, Medrol, Solu-Medrol and Cadista. It is also available as a generic drugGeneric drug
A generic drug is a medication which isproduced and distributed without patent protection. The generic drug may still have a patent on the formulation but not on the active ingredient....
.
Like most adrenocortical steroids, methylprednisolone is typically used for its anti-inflammatoryAnti-inflammatory
Anti-inflammatory refers to the property of a substance or treatment that reduces inflammation. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids which affect the brain....
effects. However, glucocorticoids have a wide range of effects, including changes to metabolism and immune responses. The list of medical conditions for which methlyprednisolone is prescribed is rather long, and is similar to other corticosteroidCorticosteroid
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiology systems such as stress , immune system and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior....
s such as prednisolonePrednisolone
Prednisolone is the active metabolite of prednisone....
. Common uses include arthritisArthritis
Arthritis is a group of conditions involving damage to the joints of the body. Arthritis is the leading cause of disability in people older than fifty-five years....
therapy and short-term treatment of bronchial inflammationInflammation
Inflammation is the complex biological response of Blood vessel tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. It is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue....
or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseaseAutoimmune disease
Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. In other words, the body attacks its own cells....
s, most notably Systemic lupus erythematosusSystemic lupus erythematosus
Systemic lupus erythematosus is a chronic Autoimmunity connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body?s cells and tissue, resulting in inflammation and tissue damage....
.
Methylprednisolone has serious side effects if taken long-term, including weight gain, glaucomaGlaucoma
Glaucoma is a group of diseases of the optic nerve involving loss of ganglion cell in a characteristic pattern of optic atrophy. Raised intraocular pressure is a significant risk factor for developing glaucoma ....
, osteoporosisOsteoporosis
Osteoporosis is a disease of bone that leads to an increased risk of bone fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is disrupted, and the amount and variety of collagen proteins in bone is altered....
and psychosisPsychosis
Psychosis , with adjective psychotic, literally means abnormal condition of the mind, and is a generic psychiatry term for a mental state often described as involving a "loss of contact with reality"....
, especially when used at high dosage. The most serious side effect occurs after the adrenal glands cease natural production of cortisoneCortisone
Cortisone is a steroid hormone. Chemically, it is a corticosteroid closely related to corticosterone....
, which methylprednisolone will replace. Abrupt cessation of the drug after this occurs can result in a condition known as Addisonian crisisAddison's disease
Addison's disease is a rare endocrine disorder in which the adrenal gland doesn't produce enough steroid hormones . It may develop in children and adults, and may occur as the result many underlying causes....
, which can be fatal. To prevent this, the drug is usually prescribed with a tapering dosage, including a pre-dosed "dose pack" detailing a specific number of pills to take at designated times over a few-day period.
Methlyprednisolone is also prescribed for spinal cord injuries (traumas). It has been proven that a dose of 30 mg/kg IV followed by IV drip at 5.4 mg / kg / hr for 23 hours improves sensory and motor recovery if given within 8 hours of the injury.
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WHICH once again makes me want to bump this thread as to anyone having taken it while on a cycle, its compared to prednisone as far as its asthma treating results but it is one strand off
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Originally Posted by racer_inboston
