Has anyone read studies on...

[mediumpimpin]

Grapefruit juice?

I was doing my usual internet whoring and came up on a study that said grapefruit juice can increase absorbtion of oral meds dramatically, It doesn't mention roids of course but wondering if it would do the same?

[dec11]

id say thts pretty much unfounded bollocks

[mediumpimpin]

No... There are studies on it proving it. I'm asking if anyone tried it with there oral stack or know more medical info to decipher if oral roids interact with enzyme CYP3A4

[Hard.On]

it is true,
but i think you have to eat half a grapefruit not just drink the juice to make it work

[trulbfan3]

yes its true and yes you can just drink the grapefruit juice...there are plents of pharmaceuticals that say DO NOT CONSUME W/ GRAPEFRUITS AND OR GRAPEFRUIT JUICE...it works well w/ drinkin winn or whatever your poision is

[ranging1]

yes ur right, and it does improve the absorbion of 17 alpha steroids

on average by about 25-50 %, and their are studies that prove this

im not going to list them all, but i found this one the easiest, and have checked it backround so its legit

Weber A, Jager R, Borner A, Klinger G, Vollanth R, Matthey K, Balogh A.

Department of Clinical Pharmacology, Friedrich Schiller University of Jena, Germany.

The effects of grapefruit juice on the bioavailability of 17 alpha-ethinylestradiol (EE2) after a single oral administration of 50 micrograms EE2 have been investigated. The pharmacokinetics of EE2 were studied in an open, randomized, cross-over study in which 13 healthy volunteers were administered the drug with herbal tea or grapefruit juice (naringin, 887 mg/ml). In contrast to herbal tea, grapefruit juice increased the peak plasma concentration (Cmax) significantly to 137% (mean; range 64% to 214%, p = 0.0088) and increased the area under plasma concentration-time curve from 0 to 8 hours (AUC0-8) to 128% (mean; range 81% to 180%, p = 0.0186). This study shows that grapefruit juice increases the bioavailable amount of EE2. A possible explanation may be that grapefruit juice inhibits the metabolic degradation of EE2. Whether the increased bioavailability of EE2 following grapefruit juice administration is of clinical importance should be investigated in long-term studies.

Publication Types:
Clinical trial
Randomized controlled trial

PMID: 8631189 [PubMed - indexed for MEDLINE]

[garyspider]

stick 2 the real ale that improves my meds!

[mediumpimpin]

What's your real Ale?

[ted666]

stick 2 the real ale that improves my meds!

its pee^^