1-test Cypionate (Injectable)

[ofthegoose1]

I know there is a pro hormone version, but I'm wondering if any one has any experience with the injectable kind?

Ive heard its somewhere in between Primo And Tren without the Tren Sides, Nice lean gains

[Merc.]

Yea I have used it .. it is good ....

Not sure if you ever saw this profile on it of not


Dihydroboldenone/1-Testosterone Profile

Pharmaceutical Name: Dihydroboldenone
Chemical Names: 17beta-hydroxyandrost-1-en-3-one, 5alpha-androst-1-en-3-one, 17beta-ol
Active Life: depends on the ester utilized
Anabolic /Androgenic Ratio: 200/100




Dihydroboldenone, most commonly known as 1-testosterone , is a 5alpha reduced form of the steroid boldenone . This lack of 5alpha reduction with the compound allows users to administer it without suffering the negative side effects associated with this chemical reaction but also eliminates the benefits as well. Boldenone is not the only steroid that shares similarities with dihydroboldenone. In fact dihydroboldenone is chemically identical to the drug methenolone except for the 1-methylation that is apart of methenolone (1). 1-methylation was of course added to methenolone to make it more available when taken orally and thus dihydroboldenone is not efficiently utilized when administered orally, although it was once sold over the counter in tablet and pill form. Some of these over the counter preparations of the drug were done utilizing a delivery system similar to Andriol , i.e. producing an oil-solubilized product with dihydroboldenone. This would still not be a relatively worthwhile system of delivery to use however if one wanted to maximize the potential of the compound. Intramuscular injection is by far the most efficient method of administration to use as with most anabolic steroids .

As mentioned above, dihydroboldenone is structurally similar to methenolone and boldenone and less so to testosterone despite the commonly used name for it, 1-testosterone. For this reason some female athletes may be inclined to use the drug as well. The potential for development of symptoms of virilization still remain but are not as severe as with synthetic testosterone or other harsher drugs. This is not to say however that dihydroboldenone is a mild drug. To simplify the explanation of exactly what the drug is, it is to boldenone as dihydrotestosterone (DHT) is to testosterone. This would explain why the effects of the drug, both positive and negative, are so dissimilar to those of boldenone. Like testosterone and dihydrotestosterone, a portion of the boldenone that a user administers converts to dihydroboldenone. Also similarly, dihydroboldenone like dihydrotestosterone does not convert to anything else past that compound.

Dihydroboldenone, while not overly androgenic, is a potent anabolic. It has been demonstrated that the drug binds extremely well and selectively to the androgen receptor and stimulates androgen receptor transactivation of dependent reporter genes (2, 3). This equates to a drug that possesses the ability to stimulate significant muscle growth while not producing androgenic side effects. It has been shown to be by far more anabolic then such compounds as boldenone, nandrolone , and even testosterone itself. Obviously this is of great benefit to many athletes.

Anecdotally some users have indicated that post-injection pain with dihydroboldenone can become an issue for some. Diluting the drug with either another injectable drug or some other type of sterile oil seems to alleviate at least some of this discomfort. The type of ester used does not appear to negate this pain for the users that experience it however.

Indeed dihydroboldenone is available in numerous different esters. Cypionate , Ethyl Carbonate, Propyl Carbonate, and Propionate , among others, are all available for use with the drug. As always each does not offer any real advantages over one another other then the obvious differing active lives that each presents and the amount of time that it takes for the body to completely eliminate the drug from it (4). For the most part users will want to have their choice dictated by the injection frequency with which they want to deal with when using the compound, but of course they will also likely be limited by those that are made available to them.


Use/Dosing

As for the duration with which dihydroboldenone can be run, due to the mild nature of the drug extended use of the compound can be completed with little in the way of serious complications arising. There are no major issues with hepatoxicity or severe kidney stress and the effect it has on other vital health markers such as blood pressure is slight in the majority of users.

As for specific dosages used with this drug, the low end is primarily thought to be three hundred to four hundred milligrams per week for male users. Like all drugs this number will vary from user to user and also depends on how much of a dramatic effect a user will want to achieve with the drug. As for the highest doses that would be worthwhile for users to attempt, this again depends on a number of variables. Doses of one gram per week are not uncommon for some users with others attempting doses in excess of this. It will always come back to how much one is willing to administer and at what point do the positives of increasing your doses begin to be outweighed by the negatives.

For females the usual rules apply with dihydroboldenone as they do with other drugs. These are namely starting out with short esters if possible so that if side effects begin to become too severe discontinuation of the drug can begin immediately and low doses should be administered at the beginning of the cycle and can be increased once the tolerance of the user is gauged. Anywhere from twenty five to one hundred milligrams per week would be a good starting point for the majority of female users who have little to moderate experience with anabolic drugs.

As stated earlier, for the frequency of dosing with dihydroboldenone it of course depends on the ester used with the compound. Seemingly the most popular current ester to produce the drug with is cypionate. No matter what ester utilized however the same rules would apply as with any other drug in terms of the frequency of administration needed to maintain relatively stable blood levels of the compound.


Risks/Side Effects

As previously indicated dihydroboldenone does not aromatize and therefore estrogenic side effects such as gynecomastia and water retention are not a concern for users. This is partly due to the drug being incapable of 5alpha reduction. Also, androgenic side effects would also be extremely infrequent for most users as there is little in the way, in terms of attributes of the drug, to produce these. These include such things as acne and hair loss, although it appears to have the potential to cause prostate enlargement. This potential for prostate growth is actually similar in frequency and severity as with that of testosterone propionate (2).

With the positive aspects of the lack of aromatization associated with dihydroboldenone also come the negative ones. Fortunately these are primarily limited to such symptoms as lethargy, malaise and possibly a reduction in sex drive. These are caused by a lower ratio of estrogen in comparison to androgens in the body. For the most part however this effect is relatively slight and can be avoided with the use of steroids that do aromatize in conjunction with dihydroboldenone and thus restore a better balance in terms of androgens versus estrogen.

It also appears that the administration of dihydroboldenone may result in an increase in liver weight (2). This effect occurred when administering the drug orally but should also be true of the drug when administered via intramuscular injection. There is no research to indicate this however.

Other common negative side effects associated with the use of anabolic/androgenic steroids are still relatively mild with the use of dihydroboldenone. Of course suppression of the natural testosterone production of users will occur like with all steroids, however other side effects such as an increase in blood pressure, acne and others are comparably mild and often times non-existent in users, at least as they are directly related to the administration of this drug.

In terms of side effects for women, at moderate to heavy doses symptoms of virilization are likely. These can include such symptoms as clitoral enlargement, body hair growth and deepening of the voice. At lower doses however these side effects should not be a concern for the majority of potential female users.



References

1. Llewellyn, William, Anabolics 2004, 2003-4, Molecular Nutrition, pp. 66-7.

2. Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schanzer W, Thevis M, Vollmer G, Zierau O, Diel P. 17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties. Toxicol Lett. 2006 Aug 20;165(2):149-55.

3. Jadrijevic D, Girardi S, Iglesias R, Lipschutz A. Antifibromatogenic and antihysterotrophic activities of synthetic androgens (19-nor-methyltestosterone , 19-nor-testosterone phenylpropionate, delta 1-testosterone and delta 1-androstenedione). Proc Soc Exp Biol Med. 1957 Oct;96(1):259-61.

4. Choi MH, Chung BC, Lee W, Lee UC, Kim Y. Determination of anabolic steroids by gas chromatography/negative-ion chemical ionization mass spectrometry and gas chromatography/negative-ion chemical ionization tandem mass spectrometry with heptafluorobutyric anhydride derivatization. Rapid Commun Mass Spectrom. 1999;13(5):376-80.



Merc.

[Merc.]

Not sure if you ever peeped this out about it either

Its a excerpt from Author . L Rea's article - prohormones, prosteroids and designer steroids ... ..


Most readers are aware of the fact that regular testosterone has some negative side effects such as making many look like a water balloon going bald. In short, testosterone metabolizes to estrogen and DHT. But, of course there are better options that allow a bit of mitigation to the DHT problem without sacrificing the advantages it has upon physique sculpting.

DHT metabolizes into a variety of different hormones such as 5-alpha androst-1-en-3,17-diol (better known as the supplement found by Patrick Arnold called 1-AD). In our body's 1-AD must convert into 1-Testosterone in order to be active. Hmmm, since 1-Testosterone is a natural metabolite of DHT then it makes more sense to skip the 1-AD conversion and directly supplement with 1-Testosterone.
1-testosterone is a surprisingly effective prosteroid (you can call it a designer steroid if you like, but it has been around awhile). It is chemically known as 17beta-hydroxy-5alpha-androst-1-en-3-one which is a derivative of dehydrotestosterone (DHT) only with fewer DHT related side-effects.

*1-Test is 5-7 times more active (anabolic ) than testosterone itself. (More lean tissue gains with fewer potential negative side effects)
*1-Test does not aromatize to estrogens. In fact some studies suggest a slight anti-estrogen effect due to aromatase inhibition. (No water retention, gynecomastia or fat gains)
*Similar to Trenbolone or high dose Primobolan Acetate in effect without the libido issues.
Injectable 1-Testosterone

Naturally, many hard-core athletes have employed 1-testosterone as a parental (injectable) preparation. Those that were able to acquire 1-Testosterone esters such as decanoate or cypionate realized the best anabolic results due to improved pharma-kinetics.
Most users of properly prepared sterile products (pyrogen free) report significant hardening of the musculature with increased lean mass tissue and fat loss at total weekly dosages of 200-300mg. There is also a surprising noted significant increase in functional strength. Many have compared 1-Testosterne Cypionate to Trenbolone in effects.
I have noted this to be so but this would suggest potential for the negative side-effects of trenbolone as well. I would suggest that the results from this type of application are closer to that of high dose Primobolan Acetate use with better over all hardening value. (Harder, leaner, stronger and hornier. Those poor lads)
*Though some companies have marketed quality "sterile" orals, it should be noted that it is not legal for anyone to administer these items as injectables.

But What Of Oral Administration?

When unprotected AAS or prosteroids are ingested orally the majority of the dosage is destroyed by the liver due to a factor called hepatic (liver) first pass deactivation. In short it means that the liver filters out your intended results and sends them to the toilet. Often this means as little as only a few milligrams (3-15%) of the original dosage makes it into the circulatory system where it can access muscle tissue.
Worse is the fact that, due to its unprotected state, the minor amount of active product that does make it into the circulatory system is destroyed and toilet-tossed during the second or third pass…within a couple hours of ingestion. This refers to the half- and active life of a chemical. Next to no absorption and very brief exposure to target tissues (uh, like muscle) means little or no results.
Hmmm, substrates that are water soluble (hydrophilic) go to the liver for assimilation or excretion and those that are oil soluble head straight to the lymphatic system thus avoiding first pass destruction.
Esters & Oily Solutions

Esterfied prosteroids (like 1-Testosterone Cypionate or Decanoate) are hydrophilic by nature (Esterized simply means that an ester chain has been added to the prosteroid structure). Lipophylic ester androgens are absorbed the same way most dietary fats (long chain fatty acids) are absorbed. After ingestion the body produces bile for emulsification and then our numerous lipase enzymes hydrolyze the compound to form what we call micelles (I did not name it so please do not blame me when trying to pronounce it).
The micelles enter the intestinal cells where they form a lipoprotein carrier called chylomicron, which is a combination of esterized prosteroid and special protein found in the small intestine. Once the compound forms the chylomicron, it is released into the lymphatic system where it is then released into the blood stream. (This means a higher percentage of active muscle building prosteroid in the blood stream.)
Remember: The lymphatic system skips the destructive first pass of the liver. An interesting note to point out is that the research with esterized steroids demonstrates oral administration with oils (MCT and sesame are oils). They mixed the active compounds with various oils, then administered the compounds orally. The inclusion of the oil facilitated improved lymphatic absorption (since this is the same way most dietary fats are absorbed, it should not be a surprise).
So the reality is that many of the "sterile" oral preparations (including 1-Test) that are esters are absorbed well orally. The fact remains however, that though effective, administration by injection allows for 100% bioavailability...but is illegal to suggest or do without medical consent and supervision.
Alkylation For Orals

The predominant of pharma oral AAS are 17-alpha alkylated. Alkylation allows the administered dosage to remain intact after the first pass through the liver thus providing much longer tissue exposure due to prolonged half-life. Without this alkylation there is considerable degradation of the active compound. It has often been said that alkylation causes undue stress upon the liver and is therefore toxic to liver tissue. In truth this is so, but on a dosage dependent level only.
Many years ago several studies were performed upon two alkylated oral AAS: Oxymetholone (AD-50) and methyltestosterone (methandrostenolone AKA D-bol should be included here due to dosage issues). The average dosages were between 100-250mg daily. After several months or use, patients showed significant elevation in liver enzymes (ALT, AST and GGT) thus suggesting a significant hepatic stress. Some currently available prosteroids (okay, Designer Steroids) have been alkylated to increase bioavailability to nearly 100% with a half-life of up to 12 hours. (Yup!)
Methyl-1-Testosterone & Other Alkylated Prosteroids

As example is methyl-1-Test. Yes, this is methylated 1-Testosterone (M-1-Test) and a highly effective oral androgen. However, it is a totally different prosteroid both in affect and activity than 1-Testosterone.
M-1-Test is far more anabolic and androgenic than 1-Testosterone. This also means that it is far more destructive to hair follicles and prostate tissue than DHT itself. When a hormone is alkylated (like adding a methyl group to the 17th ring) it totally changes the pharma-kinetics of the compound as well.
Have you noticed that most 1-Testosterone users report better sex-drive, more energy and a positive outlook upon life with their musculature gains? Yet those using M-1-Test report lethargy, no sex-drive and really bad moods to go along with high blood pressure and head-aches, oh and increased muscle mass. Personally, though effective, I dislike M-1-Test for health concerns.
This is all due to the methylated alteration that alters a chemical's effect upon androgen receptors and physiology in general. Most of this is due to secondary activity triggered by the compound such as adrenalgenic and neuro-net over-stimulation, hepatic alterations and general burn-out.
Though M-1-Test employed at a daily dosage of 10-20mg for 2-4 weeks seldom results in liver concerns (if it is a very high quality product free of other raw material metabolites and toxins), it certainly does have several negative side effects easily avoid by opting for 1-Testosterone Cypionate delivered through any viable means.



Merc.

[tske]

Did you have any side effects from it? Did it have an effect similar to tren or EQ on your cardio?

[FrostyPump]

what about cycling it? what is recommended?

[Schmidty]

bump. i need to find this later