Nandrolone might be hurting vascularity

**Kratos** · 11-30-2009, 01:11 PM

Int J Sports Med. 2009 Nov;30(11):775-8. Epub 2009 Oct 14.

Nandrolone inhibits VEGF mRNA in rat muscle.
Paschoal M, de Cássia Marqueti R, Perez S, Selistre-de-Araujo HS.

Universidade Federal de São Carlos, Ciências Fisiológicas, São Carlos, Brazil.

Vascular endothelial growth factor (VEGF) is a key compound for induction of angiogenesis in both physiological and pathological conditions. The aim of this study was to investigate the effect of androgenic -anabolic steroids (AAS) administration on VEGF mRNA expression in the rat soleus muscle after jumping training. Wistar rats were grouped into: sedentary (S); nandrolone decanoate-treated sedentary (AAS); trained without AAS (T) and trained and treated with AAS (AAST). Exercised groups performed a 7-weeks water-jumping program. Animals killed immediately after the last exercise bout showed significantly increased VEGF mRNA expression; however, the AAS treatment completely inhibited this effect. These results suggest that the AAS may be strongly prejudicial to muscle remodeling and performance at least partially due to an impaired angiogenesis. (c) Georg Thieme Verlag KG Stuttgart . New York.

**M302_Imola** · 12-01-2009, 11:23 AM

Nice post, but can you put this into lamens terms please? thanks

**Kratos** · 12-01-2009, 11:56 AM

sure, angiogenisis is growth of new blood vessels
VEGF stimulates this growth

that had some rats, made them exercise and VEGF's effects were inhibited when they were on deca vs when they weren't.

This means the muscle builds fewer new blood vessels and therfore less aerobic ability on deca vs not.

It's important if you're say a running back or something and your aerobic ability is very important.
As far as weight lifting it's still very important.

**M302_Imola** · 12-02-2009, 11:07 AM

Originally Posted by Kratos

sure, angiogenisis is growth of new blood vessels
VEGF stimulates this growth

that had some rats, made them exercise and VEGF's effects were inhibited when they were on deca vs when they weren't.

This means the muscle builds fewer new blood vessels and therfore less aerobic ability on deca vs not.

It's important if you're say a running back or something and your aerobic ability is very important.
As far as weight lifting it's still very important.

gotcha...thanks for the breakdown. That makes since.

**Hamma Head** · 12-02-2009, 11:19 AM

So deca isn't a really good steroid ?

**Kratos** · 12-02-2009, 11:52 AM

Originally Posted by Hamma Head

So deca isn't a really good steroid?

I didn't say that...just that if what holds true in mice happens in humans too, it might not be the best choice if you're concerned with endurance.

When you're cutting and doing a lot of cardio it might not be the best choice.

Also for people who are on HRT that includes deca , it could cause a lot of problems.

It's still a potent mass and strength builder, just more info to think about in you cycle choices.