DHEA - PREGNENOLONE And HPTA

**BigMatt** · 12-12-2009, 01:45 PM

1. Does Taking 25mg - 50mg of DHEA per day SHUTDOWN THE HPTA?

2. Does taking 25mg - 100mg of PREGNENOLONE per day SHUTDOWN THE HPTA ?

Thank you

**BigMatt** · 12-13-2009, 12:55 PM

Bump

**Swifto** · 12-13-2009, 01:35 PM

Originally Posted by BigMatt

1. Does Taking 25mg - 50mg of DHEA per day SHUTDOWN THE HPTA?

2. Does taking 25mg - 100mg of PREGNENOLONE per day SHUTDOWN THE HPTA ?

Thank you

No.

Exogenous DHEA administration will not shutdown the HPTA, but may shutdown endogenous DHEA production.

Taking exogenous DHEA will not boost serum testosterone levels at all, or increase performance.

Exogneous DHEA will not also decrease LH, FSH and serum T.

Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men

Gregory A. Brown, Matthew D. Vukovich, Rick L. Sharp, Tracy A. Reifenrath, Kerry A. Parsons, and Douglas S. King

This study examined the effects of acute dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and the effect of chronic DHEA intake on the adaptations to resistance training. In 10 young men (23 ± 4 yr old), ingestion of 50 mg of DHEA increased serum androstenedione concentrations 150% within 60 min (P < 0.05) but did not affect serum testosterone and estrogen concentrations. An additional 19 men (23 ± 1 yr old) participated in an 8-wk whole body resistance-training program and ingested DHEA (150 mg/day, n = 9) or placebo (n = 10) during weeks 1, 2, 4, 5, 7, and 8. Serum androstenedione concentrations were significantly (P < 0.05) increased in the DHEA-treated group after 2 and 5 wk. Serum concentrations of free and total testosterone, estrone, estradiol, estriol, lipids, and liver transaminases were unaffected by supplementation and training, while strength and lean body mass increased significantly and similarly (P < 0.05) in the men treated with placebo and DHEA. These results suggest that DHEA ingestion does not enhance serum testosterone concentrations or adaptations associated with resistance training in young men.

insulin; liver transaminases; serum lipids; serum estrogens; strength training

http://jap.physiology.org/cgi/content/full/87/6/2274

**Swifto** · 12-13-2009, 01:41 PM

You should be taking DHEA and Pregnenolone whilst on cycle. Exogenous administration of testosterone will shutdown endogneous DHEA/Preg. Therfore, it needs to be supplemented.

DHEA is important for immune function/response, labido, cognitive function, well being, energy etc...