Anyone use GnRH

[PK-V]

can it substitute for hCG

[Swifto]

Your cant use GnRH as a substitute, but I can understand why you asked.

As far as I'm aware, you cant get GnRH in a bottle, but can get GnRH agonists, such as Triptorelin Acetate. If you can get the hypothalamus to maintain some sort of endogenous GnRH, then you may be able to further supplement that small amount with a GnRH agonist....

This theory doesnt take into account various androgens direct effect on the pituitary, which you'de then need to maintain endogenous LH and FSH... Such as the ER (estrogen receptor) and progestins effects directly on the pituitary.

Then you have to think about estrogens effects on the testis directly. Would enough endogenous hormones from the meds your using (GnRH agonists etc..) be enough to prevent testicular dysfunction?

Stick with HCG for the time being IMHO.

[PK-V]

Your cant use GnRH as a substitute, but I can understand why you asked.

As far as I'm aware, you cant get GnRH in a bottle, but can get GnRH agonists, such as Triptorelin Acetate. If you can get the hypothalamus to maintain some sort of endogenous GnRH, then you may be able to further supplement that small amount with a GnRH agonist....

This theory doesnt take into account various androgens direct effect on the pituitary, which you'de then need to maintain endogenous LH and FSH... Such as the ER (estrogen receptor) and progestins effects directly on the pituitary.

Then you have to think about estrogens effects on the testis directly. Would enough endogenous hormones from the meds your using (GnRH agonists etc..) be enough to prevent testicular dysfunction?

Stick with HCG for the time being IMHO.

Sick; thanks for the info

So if someone is selling GnRH (Gonadotropin Releasing Hormone) 2000mcg in lyophilized form are just agonists and how does that differ from GnRH?

new to this sorry

so it's like comparing L3R to generic blue tops?

So stimulation is just not powerful enough to work on the same level as using synthesized external versions such as hCG?

[Swifto]

This is a very tricky subject.

When we use androgens, the hypothalamus senses an increase in androgens, estrogen's or progesterone (or all), then shuts off GnRH. So you have to firstly avoid the hypothalamus recognising the increase in either receptor.

Its sepculated that one can do this with opoid antagonists... But I havent seen anything concrete yet.

Using a GnRH agonist alone, wont suffice, I dont think.

The weak link in HPTA restoration is the testis. Not the hypothalamus/pituitary. They recover fairly qucikly post cycle, even after extended peroids.

So if the testis are the weak link. we can tackle it directly with HCG used on cycle.

[PK-V]

This is a very tricky subject.

When we use androgens, the hypothalamus senses an increase in androgens, estrogen's or progesterone (or all), then shuts off GnRH. So you have to firstly avoid the hypothalamus recognising the increase in either receptor.

Its sepculated that one can do this with opoid antagonists... But I havent seen anything concrete yet.

Using a GnRH agonist alone, wont suffice, I dont think.

The weak link in HPTA restoration is the testis. Not the hypothalamus/pituitary. They recover fairly qucikly post cycle, even after extended peroids.

So if the testis are the weak link. we can tackle it directly with HCG used on cycle.

Thanks bro that cleared up a lot