New Member
Hi there,
can you please tell me weather it makes any difference (different effect) if injecting winstrol in shoulder or your ass? I ve been told that it is better to dinject it into shoulders and am interested why? I have constant problems to inject into shoulders since the fluid hardly goes out - it looks like it stucked and cannot go into the muscle. While in the ass it goes very smoothly.
Thanks!
Mario
Retired~ AR-Hall of Famer ~ "Enforcer"
doesn't matter which muscle you inject into. what is the rest of your cycle and pct?
New Member
I am injecting trenbolone and win every second day 1ml
VET
Drink the winny if you dont like injecting it.
-XL
jing jai
VET
tren and winny huh? i take it your trying to cut fat and you think this will do the trick....good luck with that and also use of your pecker soon....Originally Posted by SLOVENCEK
AR's Think Tank
Agree. Pins can be pretty painful.
~Retired~ AR-Platinum Elite-Hall of Famer ~
Good idea
"Even sexier than Siggy"
I see this come up quite often... is there any clear facts about how much is actually utilised by the body when ingesting liquid winny orally?
Associate Member
if you use UGL winny drink it, all underground labs have not sterile winstrol injectable.
VET
You loose about 25%...so just have more...simple!
-XL
jing jai
Retired~ AR-Hall of Famer ~ "Enforcer"
horrible cycle, about as bad as it gets.
what is your planned pct?
~VET~ Extraordinaire~
i dunk my cookies in a tall glass of winny.
op
what are your stats?
That cycle is horrible
Associate Member
There's something about taking winstrol orally (If it's meant to be injected) that doesn't sounds good to me... It just doesn't sounds right.
If it were as simple as that... Why wouldn't everybody start drinking their ampules?
Or why does this can be done with winstrol, but not with another compounds? Can I start taking my injectable test orally? I don't think so...
physical pain is temporary. It may last a minute, or an hour, or a day, or a year, but eventually it will subside... The pain of quiting will lasts forever!!
actually mix this with test and you have a very good cutting cycle (if you have your food right and some cardio...)
i did a cycle of tren and prop... the prop was (bastard) either fake or very underdosed (dont trust friends on websites claiming they have good stuff) so i ran the tren and prop and ended the cycle by adding winny i was freaking ripped, shredded and reducioulsly vascular... any ways - one of my fav cycles
prop(real stuff), tren, and end it with winny
the only thing i can say is i used to inject in to my glutes with a one inch needle (too short for me) and injected winny in a vien... i got a really bad metalic taste and hit the ground could bearly breath, thought i was going to die... i wont inject winny ever again.
you could always asperate the injection to see if you were in a vien - hard to do give you self a shot in the glute...
well, you can like it or not....
i prefer just to take the oral winny tabs
AR's Think Tank
Because not everyone knows the different variations of administration with Winstrol.
Associate Member
Still... I would want to see more scientificaly proven information about that kind of method, and I haven't seen anything so far.
If it is a winstrol tab... eat it...
If it is a winstrol ampule... inject it...
Maybe not everyone knows the difference between those things.
Retired~ AR-Hall of Famer ~ "Enforcer"
how hard have you looked? people have been drinking winny for just about as long as it's been around. "can I drink winny?" is one of the most commonly questions by n00bs that experienced users always chuckle about.
Knowledgeable Member
test/tren/winny is the ultimate cutting stack.You can inject the winny where ever you want but you need to add some test to that cycle.
Anabolic Member
It makes no difference just be sure to inject deep IM.
Associate Member
+1
I would say that I have searched a lot, for quite a time... And not just one day... About all that questions about "Can I drink my winny? it hurts a lot..." I can get a thousand results, but they don't give me satisfactory answers, just some guys telling that it's ok to do it, others saying the opposite... No science involved whatsoever in the answers...how hard have you looked? people have been drinking winny for just about as long as it's been around. "can I drink winny?" is one of the most commonly questions by n00bs that experienced users always chuckle about.
This is the first time that I say: OK... Who says that and why??? (with something valid to back their answers, and not just replying: "a lot of people do it that way" "my coach told me it's ok" "rumor has it that jay cutler drinks a tall glass of winstroll upon wakening" etc, etc...
One point in favor is that either oral or injectable stanozolol is metabolized by the liver... But there're a lot of other injectable medications that pass through the liver for absorption and they have no such alternative form of administration... (Not medically approved)
No matter the form or administration (transdermal, subcutaneous, intramuscular or oral) it will get to the blood vessels, YES... But the rate of absorption is not the same... And I guess some medications may actually damage tissue at some level while "passing" through certain organs... So I sustain that IT'S NOT THE SAME...
Without worrying about the potential harmful effects of taking a stanozolol ampule in oral form... I start thinking about how much it's absorbed... Maybe 50%... And if we have to take more than normal to compensate this loss... Then, after that I could start worrying about the other side effects.
I'm not a fan of telling the same thing twice... So I will change my words a little bit...
- If you're scared, don't like injecting, can't bare the pain or simply want to take winstrol in oral form... TAKE TABLETS.
If you bought ampules, a vial, have one(s), or thinking on getting one(s)... PREPARE TO INJECT IT...
Last edited by RED26; 06-13-2010 at 06:17 PM. Reason: grammar mistakes
Retired~ AR-Hall of Famer ~ "Enforcer"
if you want to take winny orally, why would you say to get tablets rather than drinking it?
credit to Merc:
Oral winny is better for binding to SHBG , plus increasing free test...
While inject causes a much greater increase in protein synthesis and nitrogen retention..
Also
Keep in mind that oral winny has a 20 -25 % diffrence in the absorbtion rate .. So when dosing oral winny make sure to keep that in mind ...
Winstrol - Oral Versus Injectable
I tend to shy away from straight “information” articles- in other words, I’ve never written the “How Androgens Work” article, because I’ve read it several times by several authors, and I really have nothing to add. Gene Transcription and Androgen Receptor Action has been written about over, and over, ad nauseum. All of the articles I’ve read on the topic are well written and well- they’re all the same. Don’t get me wrong, all of the articles which discuss the topic are very informative, but when you’re done reading them, you don’t really have anything you can “use” in your next cycle.
And I’m sure you know the difference between orals and injectables, but do yourself a favor and read this article, because I’m going to explain some things in here that you can use in your next cycle. Actually, I’m going to explain how you can use Winstrol (Stanozolol) as either an oral or injectable, and get a very different set of effects from the same drug- depending on which route of administration you choose to utilize.
First, lets go over the basics of Winstrol, so we’re all on the same page here.
Winstrol is a steroid derived from the base structure of Dihydrotestosterone (DHT). DHT is just testosterone which has been 5alpha-reduced, meaning it has had the c4-5 double bond removed by two hydrogen atoms. This is very interesting from a chemical/biological standpoint. Once this bond is removed, testosterone has become DHT, and DHT is the body’s most potent androgen. DHT has a slew of beneficial effects which are more pronounced than the hormone it’s created out of. DHT is able to increase androgen receptor proliferation for almost 24 full hours (1) DHT also has profound effects on the Central Nervous System (CNS), and this is why we often see profoundly increased aggression with athletes who are using DHT derivatives such as Masteron (which has a deceivingly low anabolic and androgenic rating). As an added benefit, DHT can not aromatize (convert via the aromatase enzyme) into estrogen. It’s also noteworthy that the injectable version of Winstrol is actually the same exact thing as the oral- it’s just micronized Stanozolol powder suspended in water (or sometimes oil).
So what we have in Winstrol is DHT with two modifications- an added c17 methylation, and a very weird “pyrazol” group. The c17 methylation has been added in order to allow Winstrol to survive oral ingestion and the subsequent first pass through the liver. The pyrazol group is a bit weirder- what this means to you and I is that it has another whole “ring” attached to the four ring Steran Nucleus of DHT. Take a look over at the lower left portion of the two molecules below, and you’ll notice that Winstrol has an added cyclopentane (5 sided) group (the pyrazol group)
When we really take a look at Winstrol, the anabolic rating of this product is very high (320% that of testosterone) as compared to its androgenic actions (30% of testosterone). Despite this, Winstrol is really a disappointing drug for size gains. What we typically see with this stuff is some pretty decent strength gains and some nice fat loss if the user isn’t too sloppy with their diet. Not many people report huge weight gains off of Stanozolol. Although many drugs which bind tightly to the androgen receptor are suspected to exhibit their at least some of their lipolytic (fat-burning) effects through receptor binding affinity. The effects of androgens on the regulation of lipolysis in adipose precursor cells.(2), Winstrol remains a potent cutting drug, despite the fact that it has a relatively weak AR binding ability (3). What this tells me is that there’s some stuff going on with regards to Winstrol’s mechanism of action, which doesn’t involve androgen receptor mediated effects. Still, Winstrol is a very potent compound for enhancing protein synthesis (4-5 ) .
As previously discussed, it’s derived from DHT, and DHT is known to have ant-estrogenic effects (6) and Winstrol itself also has anti-progestenic properties (in at least some cases, where it may "block" that receptor) (7). So I think it’s safe to say that some of the “hard” look you can get in your physique from Winstrol is because of it’s ability to inhibit estrogen and progesterone- known culprits in making a physique appear smooth. Unfortunately, since it is 17aa, it is also liver toxic, especially more so when you inject it and it is subject to what is known as the “first pass” through the liver. The difference between taking oral vs. injectable Winstrol, even though it’s technically the same drug, is how and when your body metabolizes it. When you consume a drug orally, that drug is absorbed from the Gastrointestinal tract, where it then passes via the portal vein into the liver -where some drugs are metabolised. This “first pass” can mean that only a certain portion of the drug reaches your body’s bloodstream. As previously discussed, a 17aa has been attached to Winstrol to allow a sizeable portion to survive this metabolism.
First pass metabolism can occur in both the gut and the liver, and where this happens can vary with different drugs. First pass metabolism actually occurs in your gut for some drugs and in the liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a blood is metabolized in the Gastrointestinal tract, the blood leaving the Gastrointestinal tract does not go right to the heart, but actually still passes through liver via the hepatic portal vein and then ultimately returns to circulation via the hepatic vein. The liver is your body’s filtration unit, and removes large quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from the blood.
So as you can see, when you take an oral steroid such as Winstrol, undergoes a first-pass metabolism in the both the intestines as well as liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity, while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug then circulates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the liver again, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of Winstrol, an injectable version is available, and when we compare the oral and injectable versions of Winstrol and their effects in your body, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and only undergoes the far less extensive second pass metabolism, while the oral must endure the gut and liver on it’s first pass before ending up in circulation.
Now, here’s the interesting part: When you inject Winstrol, instead of taking it orally, you actually get more nitrogen retention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use Winstrol to build new muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are some advantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only (primarily) when taken orally.
While in the liver, on it’s first pass, Winstrol is exposed to a variety of enzymes and proteins. To understand how a possible synergy between Winstrol and other steroids may be possible, a little background on Sex Hormone Binding Globulin (SHBG) is first necessary. For our purposes here, all we need to know is that SHBG is a glycoprotein produced in the liver, which binds to testosterone and makes it biologically unavailable to do all the things we want it to do- like building muscle. It serves to transport testosterone throughout the body, but while it remains bound to testosterone, the testosterone can not exert it’s anabolic effects.
As you can surmise, a very large portion of the testosterone in your body is bound to SHBG. Wouldn’t it be great if we could lower SHBG? With Winstrol we can.
A fairly conservative oral dose of .2mg/kg of Winstrol has been shown to lower SHBG by close to 50%. (8)For me (200lbs) this would mean I would only need around 18mgs/day to free up half of my SHBG bound testosterone! For my omnipresent and hypothetical “100kg bodybuilder”- only 20mgs would be needed (he’s 220 lbs for the metrically impaired among us). Now, with less SHBG floating around in me, my anabolic steroid cycle will be more effective, right? Right.
But why can we only expect such a dramatic lowering of SHBG with the oral? Well, obviously, we’re taking advantage of the first pass through the liver, where we can have our Winstrol interact with SHBG where it’s produced- in the liver…without going through the bloodstream first.
When we take a look at a study done comparing injectable vs. oral contraceptives, we find that the oral version at 70mgs/week (10mgs/day given orally) is more effective at affecting SHBG levels than 400mgs/week given via an injection! (9)In this study, testosterone undecanoate was given at a constant dose along with norestisterone (which raises SHBG). What we see is that when norestisterone is given orally, it produces a far greater effect on SHBG, than when it is administered via an injection. And this is even when the doses of the injectable are 4x higher!
Of course, in this study, they’re looking at oral vs. injectable versions of a SHBG raising drug- but what we can take away from it is that SHBG interaction with oral compounds is far more pronounced than it is with injectables.
So lets take a small amount of Winstrol with our cycles, and free up some of those steroids we’re taking, right? Right!
Unless of course, we’re talking about women here…I was recently asked why I recommend that women use the injectable version of Winstrol over the oral. I was asked this question by someone, who I assumed had a female friend who was considering using Winstrol. I then realized I was totally incorrect- not about Winstrol, but about the reason behind the question. You see…I saw a picture of the man who had first asked me the question, and it’s readily apparent to me that he probably doesn’t actually know any women. But still, his question is valid and bears repeating and answering here.
I recommend that women avoid the oral version of this product for the same reason that men will find that it gives them an increased synergy and effectiveness in their cycles.
When SHBG is lowered in women, there is more free testosterone floating around. And as we’ve seen, the oral is going to affect SHBG exponentially more than the injectable will. When we lower SHBG too much in women, we see a strong positive correlation with hyperandrogenism (10 ), and hirsuitism (abnormal growth of body hair), as well In fact, non-SHBG-bound testosterone may actually be the defining characteristic for identifying hyperandrogenism in women. In addition, low SHBG contributes to menstrual irregularity.(11)
Finally, and (partially) anecdotally, we also see a greater incidence of clitoral enlargement and acne when the oral version of Winstrol is used by women instead of the injectable. The reasons for this are obvious- When we increase free testosterone by lowering SHBG, we increase the amount of testosterone which is able to be 5a-reduced to DHT. DHT is the primary culprit for steroid induced acne, and is also the hormone responsible for external genital enlargement. Clearly, this is why we see the increased level of clitoral hypertrophy as well as acne when oral Winstrol is used by women.
We can also see increased acne when men use Winstrol orally, but these effects are relatively minor when a 2mg/kg dose is being used to increase the effectiveness of other steroids in a cycle. This isn’t carte blanche to go using Winstrol for an extended period of time under the excuse that it’s increasing the overall effectiveness of the cycle. Stanozolol has some of the worst liver toxicity (hepatoxicity) of any oral steroid on a mg for mg basis. In addition, it’s deleterious effects on your lipid profile (Cholesterol) are also very pronounced, even at low doses- 6mgs/day of Stanozolol can lower HDL (good cholesterol)by 33% and raise LDL (bad cholesterol) by 29% (12 ).
So, hopefully, you’ve reached the end of this article and realized that Winstrol can be used in any cycle to increase the effectiveness of it, but that it must be used sparingly due to it’s possible hepatoxicity and lipid profile effecting properties. Still, when used in heavy testosterone-based profiles, at a dose that will cut your SHBG levels in half, it can increase you other steroids effectiveness quite a bit…but when maximal protein synthesis is wanted, you need to inject it.
There you go…the differences between oral and injectable Winstrol, and how you can use either form to maximize your gains! And yes, Lyle, you can drink Winny.
References:
Neural Androgen Receptor Regulation: effects of androgen and antiandrogen. Lu S, Simon NG, Wang Y, Hu S, J Neurobiol 1999 Dec; 41(4):505-12
Endocrinology. 1990 Feb;126(2):1229-34. Xu X, De Pergola G, Bjorntorp P
Endocrinology. 1984 Jun;114(6):2100-6.
Can J Vet Res. 2000 Oct;64(4):246-8.
J Am Vet Med Assoc. 1997 Sep 15;211(6):719-22
MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK 1979 Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab 49:905–916
Agents Actions. 1994 Mar;41(1-2):37-43.
Sex Hormone Binding Globulin response to the Anabolic steroid: Stanozolol: Evidence for its suitability as a Biological Androgen Sensitivity test. J Clin Metab Endocrinol 68: 1195, 1989)
The Journal of Clinical Endocrinology & Metabolism Vol. 87,No. 2 530-539. An Effective Hormonal Male Contraceptive Using Testosterone Undecanoate with Oral or Injectable Norethisterone Preparations Axel Kamischke, Tanja Heuermann, Kathrin Krüger, Sigrid von Eckardstein, Ilka Schellschmidt, Alexander Rübig and Eberhard Nieschlag Institute of Reproductive Medicine of the University (A.K., T.H., K.K., S.V.E., E.N.), D-48129 Münster, Germany; and Schering AG (I.S., A.R.), D-13342 Berlin, Germany
Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism DC Cumming and SR Wall J. Clin. Endocrinol. Metab., Nov 1985; 61: 873 - 876.
Menstrual Irregularity in Women with Acr*****ly G. A. Kaltsas, J. J. Mukherjee, P. J. Jenkins, M. A. Satta, N. Islam, J. P. Monson, G. M. Besser, and A. B. GrossmanJ. Clin. Endocrinol. Metab., Aug 1999; 84: 2731 – 2735
JAMA. 1989 Feb 24;261(8):1165-8
Associate Member
O_O!
All right! This is what I was looking for:
And that explains everything...It’s also noteworthy that the injectable version of Winstrol is actually the same exact thing as the oral- it’s just micronized Stanozolol powder suspended in water (or sometimes oil).
Well, you prove me wrong big, and I honestly thank you for that. Also I learn some things that I didn't knew, such as this:
So again, thanks for clearing it up for me, and for the rest of us.Oral winny is better for binding to SHBG , plus increasing free test...
While inject causes a much greater increase in protein synthesis and nitrogen retention..
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