Advice on GHPR-6

[Ferdinand]

I posted in GH forum but didnt get any response, post is edited a bit...

24 y
5`8
210lbs
14-16% bf
Traning for years....

Am currently on 12 weeks of 500mg/w Test-E cutting cycle and things are going great.

In week 8 i was thinking about adding GHPR-6 and run it through out PCT and 2 more months, ghpr-6 totally for 16 weeks then get bloodwork done and jump on a new cycle Test-p/masteron if BW is fine...

My thoughts about adding the ghpr-6 is to help get as much fat burned as possible and then keep/gain muscle and stay at low bf until i hit my next cycle were i will focus on upping strenght.

(am not a bodybuilder, i do crossfit and martial arts)

What do you guys think about that?

[Ferdinand]

Bump!

[tembe]

i have been using ghrp 6 for the past 2 months and have been getting good results

nice compound which u can run continually

[Ferdinand]

i have been using ghrp 6 for the past 2 months and have been getting good results

nice compound which u can run continually

So i can run this at ANY time without affecting my AAS cycles and natty test in any negative way?

And how long does it take until i can see a fat burning effect from it?

[tembe]

no

it takes quite a while to get the fat burning effect

like up to 6 months of continous use...i use it for the energy and strength

it will not affect ur aas cycles...it pulls alot of sugars from your diet for energy so helps with fat burning over time

[Ferdinand]

no

it takes quite a while to get the fat burning effect

like up to 6 months of continous use...i use it for the energy and strength

it will not affect ur aas cycles...it pulls alot of sugars from your diet for energy so helps with fat burning over time

Ok, like i said i am on a cutting cycle now and am allready fairly lean.
In 2 months i will be done cutting so i dont really need the ghpr-6 to help me LOSE the fat, but will it help keep me lean when i up the calories in 2-3 months time until i recover from this cycle and start my next one??

[tembe]

it should yes

i have only been on it for 2-3 months and i am currently on cycle so maybe im not the best person to ask that question

[Solomon]

.....

[tembe]

u can stay on it forever...most of its effects kick in around 3 month mark onwards

[Ferdinand]

It worked great during pct I must admit. After it was a bit tame, loved it for it's hunger tho.

How did you feel when u ran it during pct? Did it help with the "coming off aas" down side?

[Solomon]

....

[Ferdinand]

Some may call BS but I swear I didn't lose more thank 1lb coming off. I felt good, slept better, ate well and felt good in general. By the end of pct I was up a few lbs owing to the increase in food I guess.

Sounds good, cause i will be coming off my cycle just when school starts back up again, and i just hate to have that coming off feeling when am supposed to focus and make new relations etc.

[tembe]

i didnt lose anyuthing either

in fact i upped calories during pct to make sure of that

[Ferdinand]

What dose did you guys run?

[Solomon]

300-400iu a day

[Bonaparte]

1) HGRP-6 makes you hungry as hell, so it only be used for bulking, IMO (use GHRP-2 for cutting).

2) If legit, these peptides start working immediately. If you're having to wait 6 months for results, you're doing something wrong (like take a GHRP by itself). A GHRP should always be stacked with Mod GRF 1-29 if you want results besides hypoglycemia.

[Ferdinand]

1) HGRP-6 makes you hungry as hell, so it only be used for bulking, IMO (use GHRP-2 for cutting).

2) If legit, these peptides start working immediately. If you're having to wait 6 months for results, you're doing something wrong (like take a GHRP by itself). A GHRP should always be stacked with Mod GRF 1-29 if you want results besides hypoglycemia.

1: That i can handle, and i do TONS of hard cardio, am not a bodybuilder. I do crossfit and martial arts, am guessing i have about 10-12 hours cardio/crossfit every week and only 2-3 hours pure weightlifting so my weight will be controlled.

2: So if my ghrp6 is legit i will notice an effect right away both in strenght/energy/fatloss?

-I dont really care about mass, i just like to look lean, up endurance and be as strong as possible without getting to big and heavy for CF routines.
I also like to experiment with ghrp-6 and see how that will affect me, how will i look and how will it improve my preformance in sports..... or wont.....

Also adding: It will only be run for 4 weeks on a cutter, after those 4 weeks i will go maintenance and see how it works....

[Bonaparte]

2: So if my ghrp6 is legit i will notice an effect right away both in strenght/energy/fatloss?

Yes, IF you stack it with 100mcg of mod GRF 1-29. Without the combo, each peptide is nearly useless (they have a HUGE synergistic effect, since GHRP causes a GH release, and GRF greatly amplifies it).

[Ferdinand]

Yes, IF you stack it with 100mcg of mod GRF 1-29. Without the combo, each peptide is nearly useless (they have a HUGE synergistic effect, since GHRP causes a GH release, and GRF greatly amplifies it).

Ok, thanks for the heads up, ill go do some more research on it...

[Neevor]

Speaking of using Mod GRF 1-29 I found the following to be interesting. I know the rules say I cant post a thread to another forum so I wont do that but I hope its alright to post the article?

Synergy of GHRH + GHRP

It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and a Growth Hormone Releasing Peptide (GHRP-6, GHRP-2 or Hexarelin) results in synergistic release of GH from pituitary stores. In other words if GHRH contributes a GH amount quantified as the number 2 and GHRPs contributed a GH amount quantified as the number 4 the total GH release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 10.

While the GHRPs (GHRP-6, GHRP-2 and Hexarelin) come in only one half-life form and are capable of generating a GH pulse that lasts a couple of hours re-administration of a GHRP is required to effect additional pulses.

Growth Hormone Releasing Hormone (GHRH) however is currently available in several forms which vary only by their half-lives. Naturally occurring GHRH is either a 40 or 44 amino acid peptide with the bioactive portion residing in the first 29 amino acids. This shortened peptide identical in behavior and half-life to that of GHRH is called Growth Hormone Releasing Factor and is abbreviated as GRF(1-29).

GRF(1-29) is produced and sold as a drug called Sermorelin. It has a short-half life measured in minutes. If you prefer analogies think of this as a Testosterone Suspension (i.e. unestered).

To increase the stability and half-life of GRF(1-29) four amino acid changes where made to its structure. These changes increase the half-life beyond 30 minutes which is more than sufficient to exert a sustained effect which will maximize a GH pulse. This form is often called tetrasubstituted GRF(1-29) (or modified) and unfortunately & confusingly mislabeled as CJC-1295. If you prefer analogies think of this as a Testosterone Propionate (i.e. short-estered).

Note that some may also refer to this as CJC-1295 without the DAC (Drug Affinity Complex).

Frequent dosing of either the aforementioned modified GRF(1-29) or regular GRF(1-29) is required and as previously indicated works synergistically with a GHRP.

In an attempt to create a more convenient long-lasting GHRH, a compound known as CJC-1295 was created. This compound is identical to the aforementioned modified GRF(1-29) with the addition of the amino acid Lysine which links to a non-peptide molecule known as a "Drug Affinity Complex (DAC)". This complex allows GRF(1-29) to bind to albumin post-injection in plasma and extends its half-life to that of days. If you prefer analogies think of this as a Testosterone Cypionate (i.e. long-estered)

CJC-1295 is difficult to produce and expensive to make. As a result it could be cost-prohibitive to use extensively. Modified GRF(1-29) while less convenient is much less expensive to make and because it is a pure peptide the synthesis process is straightforward. It should sell at a fraction of the cost of CJC-1295.

...(shortened for brevity)...

Dosing GHRPs

The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg.

What that means is that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to GH release but that is it.

So 100mcg is the saturation dose and you could add more up to 300 to 400mcg and get a little more effect.

A 500mcg dose will not be more effective then a 400mcg, perhaps not even more effective then 300mcg.

The additional problems are desensitization & cortisol/prolactin side-effects.
Ipamorelin is about as efficacious as GHRP-6 in causing GH release but even at higher dose (above 100mcg) it does not create prolactin or cortisol.

GHRP-6 at the saturation dose 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range.

GHRP-2 is a little more efficacious then GHRP-6 at causing GH release but at the saturation dose or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range.

Hexarelin is the most efficacious of all of the GHRPs at causing an increase in GH release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal.
Desensitization
GHRP-6 can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

GHRP-2 probably at saturation dose several times a day will not result in desensitization.

Hexarelin has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. However dosing Hexarelin even at 100mcg three times a day will likely lead to some down regulation within 14 days.
If desensitization were to ever occur for any of these GHRPs simply stopping use for several days will remedy this effect.

Chronic use of GHRP-6 at 100mcg dosed several times a day every day will not cause pituitary problems, nor significant prolactin or cortisol problems, nor desensitize.

GHRH

Now Sermorelin, GHRH (1-44) and GRF(1-29) all are basically GHRH and have a short half-life in plasma because of quick cleavage between the 2nd & 3rd amino acid. This is no worry naturally because this hormone is secreted from the hypothalamus and travels a short distance to the underlying anterior pituitary and is not really subject to enzymatic cleavage. The release from the hypothalamus and binding to somatotrophs (pituitary cells) happens quickly.

However when injected into the body it must circulate before finding its way to the pituitary and so within 3 minutes it is already being degraded.

That is why GHRH in the above forms must be dosed high to get an effect.

GHRH analogs

All GHRH analogs swap Alanine at the 2nd position for D-Alanine which makes the peptide resistant to quick cleavage at that position. This means analogs will be more effective when injected at smaller dosing.

The analog tetra or 4 substituted GRF(1-29) sometimes called CJC w/o the DAC or referred to by me as modified GRF(1-29) has other amino acid modifications. They are a glutamine (Gln or Q) at the 8-position, alanine (Ala or A) at the 15-position, and a leucine (Leu or L) at the 27-position.

The alanine at the 8th position enhances bioavailability but the other two amino substitutions are made to enhance the manufacturing process (i.e. create manufacturing stability).

For use in vivo, in humans, the GHRH analog known as CJC w/o the DAC or tetra (4) substituted GRF(1-29) or modified GRF(1-29) is a very effective peptide with a half-life probably 30+ minutes.

That is long enough to be completely effective.

The saturation dose is also defined as 100mcg.

Problem w/ Using any GHRH alone

The problem with using a GHRH even the stronger analogs is that they are only highly effective when somatostatin is low (the GH inhibiting hormone). So if you unluckily administer in a trough (or when a GH pulse is not naturally occurring) you will add very little GH release. If however you luckily administer during a rising wave or GH pulse (somatostatin will not be active at this point) you will add to GH release.

Solution is GHRP + GHRH analog

The solution is simple and highly effective. You administer a GHRH analog with a GHRP. The GHRP creates a pulse of GH. It does this through several mechanisms. One mechanism is the reduction of somatostatin release from the hypothalamus, another is a reduction of somatostatin influence at the pituitary, still another is increased release of GHRH from the brain and finally GHRPs act on the same pituitary cells (somatotrophs) as do GHRHs but use a different mechanism to increase cAMP formation which will further cause GH release from somatotroph stores.

GHRH also has a way of reciprocally reinforcing GHRPs action.

The result is a synergistic GH release.

The GH is not additive it is synergistic. By that I mean:
If GHRH by itself will cause a GH release valued at 2
and GHRP itself will cause a GH release valued at 5

Together the GH is not 7 (5+2) it turns out to say 16!

A solid protocol

A solid protocol would be to use a GHRP + a GHRH analog pre-bed (to support the nightime pulse) and once or twice throughout the day.

For anti-aging, deep restful restorative sleep, the once at night dosing is all you need. For an adult aged 40+ it is enough to restore GH to youthful levels.

However for bodybuilding or fatloss or injury repair multiple dosings can be effective.

The GHRH analog can be used at 100mcg and as high as you want without problems.

The GHRP-6 can always be used at 100mcg w/o problems but a dose of 200mcg will probably be fine as well.

Again desensitization is something to keep an eye on particularly with the highest doses of GHRP-2 and all doses of Hexarelin.
So 100 - 200mcg of GHRP-6 + 100 - 500mcg+ of a GHRH analog taken together will be effective.
This may be dosed several times a day to be highly effective.
A solid approach is a bit more conservative at 100mcg of GHRP-6 + 100mcg of a GHRH analog dosed either once, twice, three or four times a day.
When dosing multiple times a day at least 3 hours should separate the administrations.

The difference is once a day dosing pre-bed will give a youthful restorative amount of GH while multiple dosing and or higher levels will give higher GH & IGF-1 levels when coupled with diet & exercise will lead to muscle gain & fatloss.

Dose w/o food

Administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats & carbs blunt GH release. So administer the peptides and wait about 20 minutes (no more then 30 but no less then 15 minutes) to eat. AT that point the GH pulse has about hit the peak and you can eat what you want.

All of this was writen by one DatBTrue at ProMuscle

[Ashop]

I posted in GH forum but didnt get any response, post is edited a bit...

24 y
5`8
210lbs
14-16% bf
Traning for years....

Am currently on 12 weeks of 500mg/w Test-E cutting cycle and things are going great.

In week 8 i was thinking about adding GHPR-6 and run it through out PCT and 2 more months, ghpr-6 totally for 16 weeks then get bloodwork done and jump on a new cycle Test-p/masteron if BW is fine...

My thoughts about adding the ghpr-6 is to help get as much fat burned as possible and then keep/gain muscle and stay at low bf until i hit my next cycle were i will focus on upping strenght.

(am not a bodybuilder, i do crossfit and martial arts)

What do you guys think about that?

Use some CJC1295 along with it.

[Bonaparte]

Use some CJC1295 along with it.

CJC 1295 (non-DAC) is the old misnomer for mod GRF 1-29. Same thing (usually).