Thread: tren+nolva
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07-15-2010, 08:47 PM #1
tren+nolva
I read on here a few years back that you are not suppose to use nolva with tren ? because it will cause more gyno?.. im looking into trying tren for my first time in the near future and usually i take 10mg a day of nolva throughout my whole cycle of whatever im taking.. usually a test base cycle.. because i am gyno prone. can anyone shine some light on that for me?? i can switch to aromasin but it just more pricey for me.. thanks in advance.
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07-16-2010, 02:23 AM #2Senior Member
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You should look into getting some liquid prami, prami would be better for tren prolactin gyno.
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07-16-2010, 02:57 AM #3
I've heard many times how nolva increases the chances of progesterone induced gyno when using 19nors, then decided to do some research myself and couldn't find sufficient studies to back it up. I'd be interested to see any that people could post. Perhaps swifto could chime in he's far more educated on the subject than I am.
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07-16-2010, 03:20 AM #5
Tamoxifen is a mixed ER agonist/antagonist.
In some tissues, such as the endometrium (uterus), upregulation of the PgR would be expected, as the endometrium is very sensitive to estrogen. This is where there is confusion.
In other tissues, such as the breast, Tamoxifen is an antagonist (blocks the ER). The progesterone receptor is synthesized in response to estrogen. So when the ER is blocked (in breast tissue), the progesterone receptor will also down regulate. This does not happen in cancer patients but does in healthy, normal subjects.
I hope that clears the confusion becuase you will NOT find a study stating Tamoxifen up regulates the progesterone receptor in healthy breast tissue anywhere.
The studies showing upregulation are on cancer patients and they differ from normal, healthy subjects.
Therefore, Tamoxifen will help reduce gyno when using Tren or Deca , not make it worse.
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07-16-2010, 03:28 AM #6
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07-16-2010, 03:50 AM #7Associate Member
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Bravo
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08-18-2010, 11:26 PM #8
i know i posted this a while ago, but i havent been on.. i just wanted to say thank you for helping me out.
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08-18-2010, 11:28 PM #9Anabolic Member
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We should bump this more often. Great info. I cannot tell you how many times I have heard "Do not run Nolva with a 19-nor" and then when I question it, no one can really justify their answer.
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08-19-2010, 12:51 AM #10
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08-27-2010, 11:37 AM #12
Ooooooor... its due to prolactin. Better start Caber and kemotherapy just to be safe..
Awesome post Swito! I was arguing this in a thread just the other day. I'm savin this to point to when the topic inevitably comes up again. Love the detail on the difference in Nolvas effects on different tissues..
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