Anastrozole and Joint Stiffness

[Swifto]

Ohsako T, Inoue K, Nagamoto N, Yoshida Y, Nakahara O, Sakamoto N.


Joint symptoms: a practical problem of anastrozole.

Breast Cancer 2006;13(3):284-8. http://www.jstage.jst.go.jp/article/jbcs/13/3/284/_pdf

BACKGROUND: Anastrozole and tamoxifen have mild toxicity. However, we noticed that more patients treated with anastrozole complained of joint symptoms than expected. In particular, digital stiffness as is seen with rheumatoid arthritis is a problem. Some clinical trials of anastrozole in Europe and the United States reported musculoskeletal disorders as adverse events, however, joint symptoms were not described in detail.

PATIENTS AND METHODS: At our clinic from August 2001 to March 2005, 53 postmenopausal women with estrogen receptor-positive breast cancer were treated with anastrozole. We calculated the incidence and classified the grade of joint symptoms by interviewing patients. We also investigated the patients' characteristics and their relevance to joint symptoms.

RESULTS: Of 53 patients, 14 patients (26%) had joint symptoms (13 patients with digital stiffness and 3 patients with arthralgias of wrist and shoulders). Joint symptoms tended to occur in the patients who had previously undergone chemotherapy; however, there has no relationship between prior hormonal therapy and joint symptoms. Seven patients who discontinued anastrozole treatment showed improved symptoms. Five patients with grade 1 digital stiffness continued anastrozole treatment without additional treatment. Two patients with grade 1 digital stiffness, who took a Chinese herbal medicine showed improved symptoms and continued anastrozole treatment.

CONCLUSION: Benefits to the patients may possibly be lost by discontinuation of anastrozole or changing to tamoxifen since the clinical superiority of anastrozole to tamoxifen has been reported. We should continue anastrozole in patients with low grade symptoms, while ensuring that patients are aware of the toxicity of anastrozole.





I know some people cannot use Arimidex as they get severe pain in the joints. This may not be because of Arimidex's ability to reduce circulating estrogen (as other AI's can caue joint problems) but maybe because of its toxicity.

If your one of the few, use Aromasin 10mg/ED or EOD.

[HawaiianPride.]

Exe is more effective anyways.

Another good find.

[Swifto]

Exe is more effective anyways.

Another good find.

I dont know why people even use Arimidex , its outdated IMHO, when Exemestane (Aromasin ) is cheap and easily obtainable.