Doctor says Muscle enzymes too high?

[churchill5151]

So I got my bloodwork done mid cycle, liver is good, kidneys are good, every thing is good except my muscle enzymes are very high. Apparently the "average" persons muscle enzymes should be around the 200 range where mine are around 1200?! I've already gone back for another round of blood work and the only thing my doc has said is to not train as hard. Any one else had this happen to them?

[Bonaparte]

What are these "muscle enzymes", exactly?

[jimmyinkedup]

Id suspect Cytokines which are a sign of inflamation.
Just a guess....

[Todd the truth]

Probably have elevated cPK an enzyme released when muscle tissue is damaged, large molecule which is cleared by the kidneys. If the level,is too high leads to......

Rhabdomyolysis

Last reviewed: September 19, 2011.

Rhabdomyolysis is the breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream. Myoglobin is harmful to the kidney and often causes kidney damage.

Causes, incidence, and risk factors

When muscle is damaged, a protein called myoglobin is released into the bloodstream. It is then filtered out of the body by the kidneys. Myoglobin breaks down into substances that can damage kidney cells.

Rhabdomyolysis may be caused by any condition that damages skeletal muscle, especially injury.

Risk factors include the following:

Alcoholism (with muscle tremors)

Crush injuries

Drugs, especially cocaine, amphetamines, statins, heroin, or PCP

Genetic muscle diseases

Heatstroke

Ischemia or necrosis of the muscles (which may occur with arterial occlusion, deep venous thrombosis, or other conditions)

Low phosphate levels

Seizures

Severe exertion, such as marathon running or calisthenics

Shaking chills

Trauma

Symptoms

Abnormal urine color (dark, red, or cola colored)

Decreased urine production

General weakness

Muscle stiffness or aching (myalgia)

Muscle tenderness

Weakness of the affected muscles

Other symptoms that may occur with this disease:

Fatigue

Joint pain

Seizures

Weight gain (unintentional)

Signs and tests

An examination shows tender or damaged skeletal muscles.

The following tests may be done:

Creatine kinase (CK) level

Serum calcium

Serum myoglobin

Serum potassium

Urinalysis

Urine myoglobin test

This disease may also affect the results of the following tests:

CK isoenzymes

Serum creatinine

Urine creatinine

Treatment

Getting fluids that contain bicarbonate may prevent kidney damage by quickly flushing myoglobin out of the kidneys. Fluids may need to be given through a vein (by IV). Some patients may need kidney dialysis.

Medicines that may be prescribed include diuretics and bicarbonate (if there is enough urine output).

Hyperkalemia and low blood calcium levels (hypocal***ia) should be treated right away, if present. Kidney failure should also be treated.

Expectations (prognosis)

The outcome depends on the amount of kidney damage. Acute kidney failure occurs in many patients. Getting treated soon after rhabdomyolysis begins will reduce the risk of permanent kidney damage.

People with milder cases may return to their normal activities within a few weeks to a month. However, some people continue to have problems with fatigue and muscle pain.

Complications

Acute tubular necrosis

Acute renal failure

Harmful chemical imbalances in the blood

Shock (low blood pressure)

Calling your health care provider

Call your health care provider if you have symptoms of rhabdomyolysis.

Prevention

Drink plenty of fluids after strenuous exercise to dilute your urine and flush any myoglobin that is released from your muscles out of your kidneys. Also drink a lot of fluids after any condition or event that may have damaged skeletal muscle.

References

O'Connor FG, Deuster PA. Rhabdomyolysis. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 114.
Remuzzi G, Perico N, DeBroe ME. Acute kidney injury. In: Brenner BM, ed. Brenner and Rector's the Kidney. 8th ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 29.
Review Date: 9/19/2011.

Reviewed by: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Herbert Y Lin, MD, PhD, Nephrologist, Massachusetts General Hospital; Associate Professor of Medicine, Harvard Medical School. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.



A.D.A.M., Disclaimer
Copyright © 2012, A.D.A.M., Inc.

[churchill5151]

Yup it had something to do with myoglobin released into my bloodstream. She's worried about my kidneys yet they are fine, urine is clear most times, I drink 1-2 gallons of water per day. I asked her if any of the steroids i am taking or if a diet change could affect this and she told me no. It's purely based on too much training.

[magicstick2003]

I actually knew someone this happened to. Got pretty sick due to it and actually had some major kidney issues from it. Its not one of those things you hear about too often but def ease back on training a bit till things clear up. no sense causing damage to your kidneys. The amount of water you drink probably saved ya depending how long this has been going on for.

[churchill5151]

I actually knew someone this happened to. Got pretty sick due to it and actually had some major kidney issues from it. Its not one of those things you hear about too often but def ease back on training a bit till things clear up. no sense causing damage to your kidneys. The amount of water you drink probably saved ya depending how long this has been going on for.

That seems to be the only thing I can do. Just back off the training a little bit. I'd like to see a comparison done though, between my results and some one else's who trains as much as I do. Because we all know the "normal" areas of many things do not apply to those of us who push ourselves hardest in the gym. I'm betting the normal muscle enzyme range is for some one who does not train. Just the average joe. I'll still back off the frequency of my gym days now though.