exemestane, having issues...

[n00bs]

Ok guys im currently on cycle..

500mg test e e3d
200mg nandrolone dec e3d
50mg winstrol ed
100mg oxandrolone ed

heres the problem...

I started out with 20mg exemestane ed, got e2 sides... increased to 40mg. Feeling better but still e2 sides. I have found myself taking 40mg in the morning and then another 10-20mg later throughout the day as it feels like e2 sides come on. Now i cant find a definitive source for half life. Some states 12-27hrs.

Now i must admit i seem to hyperaromatase androgens. On trt dosages i needed adex and was almost at .5mg a day.

Not many people i know use exemestane so looking for feedback on others that have used it.

Im going to continue with 60mg a day. Its just some people state 12mg is needed e2d so its doing my head in.

[decaDump]

Ok guys im currently on cycle..

500mg test e e3d
200mg nandrolone dec e3d
50mg winstrol ed
100mg oxandrolone ed

heres the problem...

I started out with 20mg exemestane ed, got e2 sides... increased to 40mg. Feeling better but still e2 sides. I have found myself taking 40mg in the morning and then another 10-20mg later throughout the day as it feels like e2 sides come on. Now i cant find a definitive source for half life. Some states 12-27hrs.

Now i must admit i seem to hyperaromatase androgens. On trt dosages i needed adex and was almost at .5mg a day.

Not many people i know use exemestane so looking for feedback on others that have used it.

Im going to continue with 60mg a day. Its just some people state 12mg is needed e2d so its doing my head in.

Dude, you're taking too much at once. KISS method, my friend.

"It's not what you gain, it's what you maintain." dD

[The Bear 79]

Holy sh!t man! You're using way too much, 10 mg/ed is more than enough for the doses of your cycle, & some people dont even use that much, some only use 12.5 mg/eod. You're killing your estrogen, you're probably feeling really drained & lethargic aren't you?

[The Bear 79]

"Exemestane reaches steady blood plasma levels of after a week of administration and this is also when we see it begin its maximal effect on reducing circulating estrogen levels. It’s also has a ½ life of 27 hours (4), so taking it once per day is going to build up blood plasma levels to a very effective level."

References:

1. A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation.Br J Clin Pharmacol. 2005 Mar;59(3):355-64.

2. Eur. J. Cancer. 2000, May;36(8):976-82

3. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 12 5951-5956Copyright © 2003 by The Endocrine Society

4. Clin Cancer Res. 2003 Jan;9(1 Pt 2):468S-72S

5. Anticancer Res. 2003 Jul-Aug;23(4):3485

6. J Clin Endocrinol Metab. 2003 Dec;88(12):5951-6.

[Bonaparte]

I would just switch to Letro, since your aromasin clearly isn't working.

[DanB]

Is it ugl, r.c or pharm? My guess is if it ain't pharm it underdosed or bunk

EDIT

I'm assuming it r.c due to the dosing, don't know how you would get 20-40mg from pharm tablets, as matter of interest can you pm me who you got it off so I can add them to my list of garbage research companys.....

[Ashop]

60mg is alot of EXEMESTANE...the majority only need 12.5mg daily or even less.

[DGK]

yeah i take 12.5 ed// at most

[cb714]

Chances are your aromasin is fake brotha. Standard dose is 12.5mg ed and that seriously drops your estrogen levels down. This cycle Im doing 25mg eod just cuz I got the 25mg tabs. I havent noticed any significant difference from take 25eod vs 12.5ed. But yeah, you're taking way to much if it is real (which I doubt).

[n00bs]

powder was imported... so isnt from a research place everything else is legit from them .
it has that crystal look sort of like taurine.

im getting bloods drawn tomorrow.

remember i was taking 250mg test e week and needed 0.5mg adex day. either i aromatise too much/ its bunk/ or its from deca?

[cb714]

I hear you but exemestane permanently deactivates the aromatase enzyme and it suppresses about 85% of your estrogen. It's a very effective AI. Something sounds a little off.

[Bonaparte]

powder was imported... so isnt from a research place everything else is legit from them .
it has that crystal look sort of like taurine.

im getting bloods drawn tomorrow.

remember i was taking 250mg test e week and needed 0.5mg adex day. either i aromatise too much/ its bunk/ or its from deca?

Aromasin should be a fine, very light (low density), white powder. Sounds like you were sold something else.

[HitIt]

like to see what your prl and e2 is before you run anything else and then you best get some real stane.

[DGK]

yeah click the banner up top and get the ;iquid stane

[n00bs]

It is like that but once you mix with ethanol and glycerol you get that consistency.

This is from a major supplier.. everything has been good from halo to methyltren. All legit.

I must say that i also had the same issue with another supplier of exem, a RC place.



From my history all i can conclude is i have some form of hyper-aromatase. As originally before touching gear i had below range test and above range e2. Now that im cranking through the test naturally that would exacebate the situation.

[HitIt]

well hyper anything isn't fun. but if you think your stane is good i'd be even more interested in those blood numbers at 60 mg a day