GW-501516 Compound

**StrengthFromWithin** · 05-15-2012, 09:13 PM

I have found a reputable source for this compound. However, there currently is not a lot of research on it. I've seen a few studies and from my understanding, it appears it is currently being studied by GlaxoSmithKline.

I'm looking for others inputs. Anyone here experimented with it (guinea pigged it)? Any light you might have to shed on this would be appreciated. The current source is claiming a 99% purity rate... Thinking of being my own test lab mouse.

Thanks-

-- For those of you new to the compound, here's a description --

"(also known as GW-501,516,GW1516 or GSK-516) is a PPAR***948; modulator compound being investigated for drug use by GlaxoSmithKline.[1][2] It activates the same pathways activated through exercise, including PPAR***948; and AMP-activated protein kinase. It is being investigated as a potential treatment for obesity, diabetes, dyslipidemia and cardiovascular disease. [3] [4] GW-501516 has a synergistic effect when combined with AICAR: the combination has been shown to significantly increase exercise endurance in animal studies more than either compound alone. [5][6]

GW-50156 regulates fat burning through a number of widespread mechanisms [7]; it increases glucose uptake in skeletal muscle tissue and increases muscle gene expression, especially genes involved in preferential lipid utilization.,[8][9] [10] This shift changes the body's metabolism to favor burning fat for energy instead of carbohydrates or muscle protein, potentially allowing clinical application for obese patients to lose fat effectively without experiencing muscle catabolism or the effects and satiety issues associated with low blood sugar. [11] GW-501516 also increases muscle mass, which improved glucose tolerance and reduced fat mass accumulation even in mice fed a very high fat diet, suggesting that GW-501516 may have a protective effect against obesity [12]

It has been demonstrated at oral doses of 5 mg a day to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, most likely by stimulating fatty acid oxidation.[13] Treatments with GW-501516 have been shown to increase HDL cholesterol by up to 79% in rhesus monkeys and the compound is now undergoing Phase II trials to improve HDL cholesterol in humans. [14]"

**cantbetouched** · 05-15-2012, 09:41 PM

interested but i heard you can lose muscular hypertrophy on this product. it's is supposedly increases endurence and strips bodyfat. the logs i've seen ppl run 5mged and some loose weight real fast water weight and then it slows. also some sites have documented this causeing intestinal polyps.. in rats who were predisposed. i say if you really wanna get rid of some fat the easy way do it otherwise hit the cardio and diet better. it'll be safer imho!

**SimplyFlawless** · 05-16-2012, 09:31 AM

I started using it because I saw it could increase HDL cholesterol, which is an issue for me. I've been on it like 2 weeks now. Where did you hear it causes muscle loss?

**cantbetouched** · 05-16-2012, 09:02 PM

not muscle loss loss of hypertrophy in turn the transformation of type 1 and type 2 muscle fibers.

**Weah** · 10-25-2012, 04:15 PM

Originally Posted by cantbetouched

not muscle loss loss of hypertrophy in turn the transformation of type 1 and type 2 muscle fibers.

So that means that you will lose explosivity? Where have you read this?

**Times Roman** · 10-25-2012, 04:23 PM

yes. i have been researching this compound for awhile now. I'm investing with some partners in 50 grams and hopefully will arrive soon. there are a couple of threads where the members are keeping track of the effects GW has on them.

the stomach polyps are NOT fatal. The risk of stomach polyps can be minimized with the use of Cox2inhibitors such as Celebrex. Or, you can do what I'm planning on doing and capping my GW with tribulus. Tribulus is also a Cox2i and will reduce this risk by over 80%.

I have a thread that states the risks of GW. I posted it a few weeks ago. If you need any information, let me know.....

**Weah** · 10-25-2012, 07:29 PM

Originally Posted by Times Roman

yes. i have been researching this compound for awhile now. I'm investing with some partners in 50 grams and hopefully will arrive soon. there are a couple of threads where the members are keeping track of the effects GW has on them.

the stomach polyps are NOT fatal. The risk of stomach polyps can be minimized with the use of Cox2inhibitors such as Celebrex. Or, you can do what I'm planning on doing and capping my GW with tribulus. Tribulus is also a Cox2i and will reduce this risk by over 80%.

I have a thread that states the risks of GW. I posted it a few weeks ago. If you need any information, let me know.....

I would like to have as much info about it as possible, and another SARMs too. So you are saying that I will be less explosive if I will use it? It's really important for me to get a answer here, I need to get it in with a teaspoon

For me being a football player that means I will lose some of the advantage I have when it comes to sprinting. I'm currently taking Ostarine, and have used it for 10 days and can't say I feel much difference yet. The two sarms I am reading and thinking about using is Gw and Mk-501516.

**MuscleInk** · 10-25-2012, 07:31 PM

Originally Posted by Weah

I would like to have as much info about it as possible, and another SARMs too. So you are saying that I will be less explosive if I will use it? It's really important for me to get a answer here, I need to get it in with a teaspoon

For me being a football player that means I will lose some of the advantage I have when it comes to sprinting. I'm currently taking Ostarine, and have used it for 10 days and can't say I feel much difference yet. The two sarms I am reading and thinking about using is Gw and Mk-501516.

Just to clarify, GW is a PPAR, not a SARM.

**t-dogg** · 10-25-2012, 07:39 PM

My explosive and fast twitch has stayed the same. Sprints, power cleans, ext.

Ive used it from 5-20mgs a day.

**Times Roman** · 10-25-2012, 07:46 PM

maybe someone can throw in a link to antomini's GW thread?

**Atomini** · 10-25-2012, 07:48 PM

I've used it up to 40mg per day. I have a log on here, and you can find it via the search function. I'm too lazy right now to find it and post the link directly.

**MickeyKnox** · 10-25-2012, 08:02 PM

Atomini's GW-501516 Thread

http://forums.steroid.com/showthread...6#.UInvG2fX_fs

**Times Roman** · 10-25-2012, 08:02 PM

Originally Posted by Atomini

I've used it up to 40mg per day. I have a log on here, and you can find it via the search function. I'm too lazy right now to find it and post the link directly.

why don't you help OP out and throw your link here so he can check out your log?

**Times Roman** · 10-25-2012, 08:03 PM

never mind....
....mickey beat you to it!

**Weah** · 10-26-2012, 10:20 AM

Originally Posted by Atomini

I've used it up to 40mg per day. I have a log on here, and you can find it via the search function. I'm too lazy right now to find it and post the link directly.

I have read the log many times and think the info you are giving and the log is great. The problem is that I am still not sure if I should use it. My problem is that I am really insecure when it comes to the switching of muscle fibers. In football you need to be explosive to get past players and speed is one the advantages I have in football. I don't wanna have better endurance instead of strength and explosivity. I am pretty strong and unlike other football players I love deadlift,benchpress and front squatting. At the moment my 1rpm is 260kg in deadlift and I have a goal to lift 300kg in the end of year. Can someone give me an answer about this?

**Atomini** · 10-26-2012, 10:39 AM

Originally Posted by Weah

I have read the log many times and think the info you are giving and the log is great. The problem is that I am still not sure if I should use it. My problem is that I am really insecure when it comes to the switching of muscle fibers. In football you need to be explosive to get past players and speed is one the advantages I have in football. I don't wanna have better endurance instead of strength and explosivity. I am pretty strong and unlike other football players I love deadlift,benchpress and front squatting. At the moment my 1rpm is 260kg in deadlift and I have a goal to lift 300kg in the end of year. Can someone give me an answer about this?

There is no 'switching' or 'converting' of muscle fibers. The body either grows more white fast twitch fibers, or it grows more red slow twitch fibers (while potentially reducing the amount of either antagonistic type). What determines the disposition of slow-twitch to fas-twitch fibers in your body is primarily genetics, and then comes training stimulus. If your training stimulus is that of anaerobic quick-firing strength type movements with low rep ranges, then you're stimulating your body for more fast-twitch fiber production. If you are training for endurance, then you can put 2 and 2 together and figure it out from there. If i'm using GW for fat loss, but my only training stimulus is that of anerobic exercise, then I am keeping the slow-twitch muscle fiber conversion to an absolute minimum. If I were to throw AICAR in there, i'd end up tipping the favor more towards slow-twitch fiber production than I ideally want. There is absolutely no chance in hell that you would take GW and train in a fast-twitch promoting manner and end up losing 90% of your fast-twitch fibers to slow-twitch all because you started taking GW. It doesn't work that way. I used GW for months on end at high doses and my strength did not drop in any of my exercises, and I did not become a lanky skinny marathon-jogger type physique...

Of course, you'll never change what your genetics pre-determine you to have though. If your genetics have determined you to be 90% fast-twitch type, you can train yourself to get better at long-distance jogging, but there's no chance in hell you're going to be as good of a marathon runner as someone who was naturally born into it. It works vice-versa too.

**Weah** · 10-26-2012, 01:06 PM

Wow! Thank you, I really appreciate that you are taking your time to answer me. So you think the Gw will be good for my football skills? When it comes to the endurance part, will it give me long term effects or will that depend on many factors? I want to ask the same question about Sarms . Do someone have some info about Mk-677? I am currently using Ostarine at the time and have taken 12.5 in 10days. Up to now it seems like I have been more vascular and getting a little stronger.

**Weah** · 10-27-2012, 06:06 PM

A little bump here. I just wonder if someone can give me some tips about what kind of compound that will help me with my soccer, getting stronger/faster and heal my knee. This is so important to me, please give me some feedback.

Like I have said before, I am using Ostarine and 10 mg testogel that is subscribed by my doc. The Ostarine seems to work better for each day, have used for 14 days now, and strong and that I can train hard and not feeling especially tired the workout.