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Thread: Propranolol (beta receptor upregulator?)/ alternatives

  1. #1

    Propranolol (beta receptor upregulator?)/ alternatives

    Looking for easier to get alternatives to ketotifen and T3 (beta receptors upregulators) I came across Propranolol.

    I havent made deep research into it but have found some interesting stuff about it. It may help upregulate beta receptors 1 and 2. My english is not that great and I find it difficult sometimes to understand complex terms and so on (I might be wrong about this, hopefully not).

    I found this site dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=4217 and flipper.diff.org/app/items/info/2600 that kind of say the same.

    Can anyone confirm that Propranolol Hydrochloride can actually up regulate beta receptors. Good thing about Propranolol is that I can get it at any pharmacy over the counter. This way I don't have to wait 2 weeks for my ketotifen to arrive.

    Also, does anyone know of another WORKING alternative?

    thanks in advance.

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    Quote Originally Posted by bosh1911 View Post
    Looking for easier to get alternatives to ketotifen and T3 (beta receptors upregulators) I came across Propranolol.

    I havent made deep research into it but have found some interesting stuff about it. It may help upregulate beta receptors 1 and 2. My english is not that great and I find it difficult sometimes to understand complex terms and so on (I might be wrong about this, hopefully not).

    I found this site dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=4217 and flipper.diff.org/app/items/info/2600 that kind of say the same.

    Can anyone confirm that Propranolol Hydrochloride can actually up regulate beta receptors. Good thing about Propranolol is that I can get it at any pharmacy over the counter. This way I don't have to wait 2 weeks for my ketotifen to arrive.

    Also, does anyone know of another WORKING alternative?

    thanks in advance.
    Yes, propranolol is a beta blocker. It's typically used to treat hypertension, but is also used to treat Generalised Anxiety Disorder. If you've ever watched bigger, faster, stronger; this is the beta blocker the musicians are talking about. Yes there are other pharmaceutical alternatives, propranolol is typically the safest. I'm not quite sure what you mean with "up regulate". It is a beta receptor antagonist. It occupies beta receptors without illiciting a response, so that epinephrine is unable to attach.

  3. #3
    Quote Originally Posted by Bigshotvictoria View Post
    Yes, propranolol is a beta blocker. It's typically used to treat hypertension, but is also used to treat Generalised Anxiety Disorder. If you've ever watched bigger, faster, stronger; this is the beta blocker the musicians are talking about. Yes there are other pharmaceutical alternatives, propranolol is typically the safest. I'm not quite sure what you mean with "up regulate". It is a beta receptor antagonist. It occupies beta receptors without illiciting a response, so that epinephrine is unable to attach.
    I need to regulate my beta receptors because for some reason they are very low or simply not regulated. I took albuterol for the first time for 2 weeks and it didn't do anything to me, then I tried clen 120mcg at once on my first ever dose and again, didn't do anything (like if I hadn't taken anything). So from what I have read my receptors are low and need regulation. I am taking 2-3 weeks off and while I wait for the ketotifen, I want to try an alternative to ketotifen or T3 like propranolol.

    Again to confirm. Will it work? And thanks for the reply

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    Quote Originally Posted by bosh1911 View Post
    I need to regulate my beta receptors because for some reason they are very low or simply not regulated. I took albuterol for the first time for 2 weeks and it didn't do anything to me, then I tried clen 120mcg at once on my first ever dose and again, didn't do anything (like if I hadn't taken anything). So from what I have read my receptors are low and need regulation. I am taking 2-3 weeks off and while I wait for the ketotifen, I want to try an alternative to ketotifen or T3 like propranolol.

    Again to confirm. Will it work? And thanks for the reply
    and you know this how, exactly? sometimes i have to laugh at how drugs are regarded as sweets...........

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    Quote Originally Posted by bosh1911 View Post
    I need to regulate my beta receptors because for some reason they are very low or simply not regulated. I took albuterol for the first time for 2 weeks and it didn't do anything to me, then I tried clen 120mcg at once on my first ever dose and again, didn't do anything (like if I hadn't taken anything). So from what I have read my receptors are low and need regulation. I am taking 2-3 weeks off and while I wait for the ketotifen, I want to try an alternative to ketotifen or T3 like propranolol.

    Again to confirm. Will it work? And thanks for the reply
    No. Clen is a beta receptor agonist. It stimulates the sympathetic nervous system in a similair way to epinephrine. Propranolol is a beta receptor antagonist. It blocks the receptor so sympathamomemics like epinephrine, clen, and albuterol can't stimulate the receptor. In fact, taking propranolol alongside clen would actually block clen from illiciting it's effects.
    Last edited by Bigshotvictoria; 09-22-2012 at 05:13 AM.

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    Quote Originally Posted by Bigshotvictoria

    No. Clen is a beta receptor agonist. It stimulates the sympathetic nervouse system in a similair way to epinephrine. Propranolol is a beta receptor antagonist. It blocks the receptor so sympathamomemics like epinephrine, clen, and albuterol can't stimulate the receptor. In fact, taking propranolol alongside clen would actually block clen from illiciting it's effects.
    Correct. More or less.

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    Quote Originally Posted by bosh1911 View Post
    I need to regulate my beta receptors because for some reason they are very low or simply not regulated. I took albuterol for the first time for 2 weeks and it didn't do anything to me, then I tried clen 120mcg at once on my first ever dose and again, didn't do anything (like if I hadn't taken anything). So from what I have read my receptors are low and need regulation. I am taking 2-3 weeks off and while I wait for the ketotifen, I want to try an alternative to ketotifen or T3 like propranolol.

    Again to confirm. Will it work? And thanks for the reply

    I don't know why you think your beta receptors are "low" or "not regulated". You should get off webMD, you're drawing some strange conclusions. Instead of giving you a lesson in pathophysiology, just take my word for it.

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    Quote Originally Posted by asiandude View Post
    Correct. More or less.
    No, theres no more or less. thats completely correct, assuming he was truly beta blocked.
    Last edited by Bigshotvictoria; 09-22-2012 at 05:40 AM.

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    Quote Originally Posted by Bigshotvictoria

    No, theres no more or less. thats completely correct, assuming he was truly beta blocked.
    I really hate to go into the details, but since you insist...

    Clen is a beta-2 agonist. Epinephrine is a non-specific (meaning both alpha and beta) agonist. So your statement is more or less correct, but not completely.

    And the correct term is "sympathomimetic", not .... whatever you wrote.

    Sorry.

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    Quote Originally Posted by asiandude View Post
    I really hate to go into the details, but since you insist...

    Clen is a beta-2 agonist. Epinephrine is a non-specific (meaning both alpha and beta) agonist. So your statement is more or less correct, but not completely.

    And the correct term is "sympathomimetic", not .... whatever you wrote.

    Sorry.
    I figured it was safe to assume he could care less about the difference between beta1 and beta2 receptors, or that he even knows that there are alpha rectors, considering he wants to up regulate his beta receptors with propranolol.

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    Quote Originally Posted by Bigshotvictoria

    I figured it was safe to assume he could care less about the difference between beta1 and beta2 receptors, or that he even knows that there are alpha rectors, considering he wants to up regulate his beta receptors with propranolol.
    Now this statement is completely correct!

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    Quote Originally Posted by asiandude View Post
    Now this statement is completely correct!
    And as you can clearly see by my spelling, I have retarded iPhone thumbs.

  13. #13
    haha thanks for the replies (srs). My English is not that great that's why I have trouble understanding complex stuff. Good to know it will block my receptors and not regulate them. I don't intend to take propranolol to run clen/albu for longer, I wanted it to regulate my receptors... Anyway, I know there are alpha receptors but I am only interested in 2 and 3. maybe 4. as these are ones that will help me use fat as energy (not sure about scientific terms so I wont mention them). Not sure about beta1 and the alpha receptors...

    If you read my thread forums.steroid.com/showthread.php?513102-Clen-Albuterol-NO-SIDES-WTF#.UF24MY3iYU4 you will know why I want to regulate them. I draw my conclusion from answers I got from these forum and other one. I don't think its normal to have taken clen and abluterol and have no results or sides, NOTHING! I checked everything including heart rate ofc. I spent a lot of time researching both clen and albuterol, specially the sides and I am not getting any from clen or albuterol, also I only lost 1kg in two weeks on a strict carb cycling diet while taking albuterol, I am also doing HIIT a minimum of 3 days a week for 15-20min).

    tomorrow makes two weeks since I started my diet and the cycle. I have NEVER taken clen, albuterol, ephedrine or anything else. Tho I have been taking CLA these two weeks and stopped taking it yesterday. (CLA promotes the breaking down of fat to be used as energy, don't know if it affects my receptors tho)

    Both my sources of clen are of good quality. albuterol is from a research company (the one most mentioned on this forums) and clen is a pharmaceutical grade one (claire gel clen for horses. for horses because I am from STRAYA MATE lol).

    If there is nothing wrong with my receptors, then why clen and albuterol are not working?

  14. #14
    just testing if I could post. My reply to all of you is being checked by mods. Dunno when it will appear. Thanks for the replies tho. You will understand what I mean and what I need.

  15. #15
    I think my reply wont appear, I will write it again...

    I can't post links so please find my thread called " Clen/Albuterol NO SIDES WTF " That's my experience with albuterol and clen so you understand where I am coming from...

    I know there are alpha receptors tho I don't know about them, as for the beta I know that 2 and 3 are responsible for fat burning (use fat as energy), not sure about 1 and 4. Clen and albuterol target 2 and 3, propranolol targets 1 and 2 which is better than nothing.

    Good to know that propranolol won't work, so I don't waste time and money on it. I needed it to regulate my beta receptors because I believe they are low or f* up for some reason. Albuterol and clen didn't do anything to me and they are of good quality. I took albuterol for 10 days and nothing (up to 16mg at once and total 38mg a day), then I took clen 120mcg at once and again, NOTHING. And this is the first time in my life I take albuterol or clen. I have made plenty of research on both, specially on their sides so I know they are not doing anything for some reason.

    Appart from that I have been taking fish oil, elastamine (for joints), vit C, multivitamin and doxycycline which is a used to treat acne (will research on this asap). AND when I started all of this I also started taking CLA which too promotes the use of fat as energy, tho I don't how (not sure if it hits my receptors).

    I am on a carb cycling diet and have only lost 1kg in 2 weeks which is not much for my first to weeks cutting and considering I took albuterol, clen and CLA.

    I don't think its normal for this to happen, you guys are the experts, hopefully you can help me out as I have spent time and money on this products and they are not working for me, and not just that, I am more worried about my health, there must be something wrong with me and albuterol, clen or CLA didn't cause it.

    Thanks

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    in your other thread, i was wondering about your low resting heart rate. one thing that just pop in my mind is hypothyroidism. its just one of the many possibility that may cause your low HR and also your difficulty in losing fat. there are many other possibilities. i think it may be better to see your dr for checks before you try anything else, and waste more money.

  17. #17
    Quote Originally Posted by asiandude View Post
    in your other thread, i was wondering about your low resting heart rate. one thing that just pop in my mind is hypothyroidism. its just one of the many possibility that may cause your low HR and also your difficulty in losing fat. there are many other possibilities. i think it may be better to see your dr for checks before you try anything else, and waste more money.
    Thanks, sounds like I have no choice. What should I tell him? I am not sure if I should mention him albuterol or clen... Will "having problem loosing fat" will be enough? should I mention hypothyroidism??? Is there a test that can be made to check receptors like a blood test?

    By the way yesterday morning I checked my HR as soon as I got up and was 60bpm, if that makes a difference. I will log it this week when I wake up and before bed every day.

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    Quote Originally Posted by bosh1911

    Thanks, sounds like I have no choice. What should I tell him? I am not sure if I should mention him albuterol or clen... Will "having problem loosing fat" will be enough? should I mention hypothyroidism??? Is there a test that can be made to check receptors like a blood test?

    By the way yesterday morning I checked my HR as soon as I got up and was 60bpm, if that makes a difference. I will log it this week when I wake up and before bed every day.
    You can say its hard to lose weight, mention your slow heart rate, and describe to him your current diet and exercise program. There is no easy way to test your adrenergic receptors. But you can test your thyroid hormones and do an ekg to check your rhythm.

    60 beats per min is almost acceptable as normal, but usually happens in very fit athletes. You did mention that you're terrible with cardio...

  19. #19
    Quote Originally Posted by asiandude View Post
    You can say its hard to lose weight, mention your slow heart rate, and describe to him your current diet and exercise program. There is no easy way to test your adrenergic receptors. But you can test your thyroid hormones and do an ekg to check your rhythm.

    60 beats per min is almost acceptable as normal, but usually happens in very fit athletes. You did mention that you're terrible with cardio...
    thanks again, will go this week. Yeah I used to do cardio like 2-3 times a week and could jog for over an hour at a decent speed. but this was over 2 years ago. In the mean time I have rarely done any cardio and if I ever did it was never for more than 20min. When I started the cut I realised how bad my cardio performance was so I will try keep my cardio up regardless of cut or bulk.

    I will inform on my other thread my results with the doc and will update my cut results once a week. thanks again for everything

  20. #20
    Propranolol is usually used for anxiety and should not be used to treat high blood pressure or fast heart rhythm. Reason being it is fast acting and doesn't last long. After the effects of the medicine are gone you will experience a rebound of your symptoms of HBp or fast heart rhythm. Beta blockers used for hbp need to be taken consistently and cannot be stopped abruptly.

  21. #21
    Quote Originally Posted by GreatSuccess View Post
    Propranolol is usually used for anxiety and should not be used to treat high blood pressure or fast heart rhythm. Reason being it is fast acting and doesn't last long. After the effects of the medicine are gone you will experience a rebound of your symptoms of HBp or fast heart rhythm. Beta blockers used for hbp need to be taken consistently and cannot be stopped abruptly.
    Good to know, another reason to not get it. thanks

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