My wife is 35 yrs old, 5'6" and 148 pounds, up from 135 a year ago. I was involved in a serious accident that required 5 surgeries and the stress of having to take care of me caused her to put on a lot of weight. As of twenty days ago, she weighed 158 pounds.

She had her thyroid destroyed pre-puberty from grave's disease/hyperthyroidism, so she's been on thyroid medications most of her life to manage this issue. Because of her condition, she's also always found it impossible to lose weight. Her diet is impeccable, so please, don't start in on that. We have worked with more 7 different personal trainers and more than half a dozen MD's and ND's and each has tried their spin on things and she has followed whatever they've asked to a "T".

Most recently, as a list ditch effort to move the scale, she did the HCG 500 calorie diet and today we met with the naturopath to check in after the first 22 days. As a result of following the HCG 500 calorie diet 100% by the book, she lost 10 pounds, of which 9 were lean muscle mass!!!! Only one pound of fat after starving herself and taking HCG, which did nothing for her just like everything else she has tried - and I mean everything.

We have spent over $20,000 over the past 11 years trying to help her and as she gets older, the problem gets worse. Her other naturopath who is also a compounding pharmacist blames everything on exhausted adrenals and keeps having her take tons of different pills that have helped her in terms of being able to sleep and not have heart palpatations, but after 3 years, she got no results from her workouts.

She was working out 6 days a week with a PT, 30 mins a day lifting plus 30 min of cardio, Dr. told her that was stressing her body out and wanted her to do long, slow cardio to keep her from going into "fight or flight" mode, so she did and was literally walking on the treadmill for 1.5 hours a day, 5 days a week.

This is just one tiny sliver of all the things she has tried. We're both very knowledgable when it comes to fitness, diet, etc. myself included. Before my accident I as 178 pounds with 8% bodyfat at 5'9", up from 138 pounds 5 years earlier and I did it all naturale`.

In the end, I give a background so someone doesn't reply "she just needs to dial in her diet and up her cardio", or "do fasting cardio", or "hiit" or anything else. Trust me, we've tried all of it. She's an extremely hard worker and loves to workout, but no one loves to workout when you not only don't get the results you desire, but you actually get worse.

Her body seems basically incapable of burning fat. So, here is my question.

Will Clenbuterol possibly help her? Are there any others out there with hypothyroidism or adrenal fatigue issues that have found anything that worked. If you have had these issues, you know how hopeless and frustrating it can be to bust your ass and actually get fatter as your body goes into fight or flight mode.

So, any experts out there on this issue? I realize this case is extremely complex, way more complex than what I've covered here, but this hits some of the high points and I'm just wanting to see if there is anyone outside of the traditional and even non-traditional paths out there that might be able to help because the MD's, dieticians, personal trainers, etc. haven't been able to do anything.